Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes

Diffuse intrinsic pontine glioma (DIPG) is the most severe paediatric solid tumour, with no significant therapeutic progress made in the past 50 years. Recent studies suggest that diffuse midline glioma, H3 - K27M mutant, may comprise more than one biological entity. The aim of the study was to dete...

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Bibliographic Details
Published in:	Acta neuropathologica Vol. 130; no. 6; pp. 815 - 827
Main Authors:	Castel, David, Philippe, Cathy, Calmon, Raphaël, Le Dret, Ludivine, Truffaux, Nathalène, Boddaert, Nathalie, Pagès, Mélanie, Taylor, Kathryn R., Saulnier, Patrick, Lacroix, Ludovic, Mackay, Alan, Jones, Chris, Sainte-Rose, Christian, Blauwblomme, Thomas, Andreiuolo, Felipe, Puget, Stephanie, Grill, Jacques, Varlet, Pascale, Debily, Marie-Anne
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-12-2015 Springer Nature B.V
Subjects:	Astrocytes - metabolism Astrocytes - pathology Astrocytes - radiation effects Biopsy Brain Stem Neoplasms - diagnosis Brain Stem Neoplasms - genetics Brain Stem Neoplasms - pathology Brain Stem Neoplasms - radiotherapy Cancer Cell cycle Child Child, Preschool Cohort Studies Female Gene expression Glioma - diagnosis Glioma - genetics Glioma - pathology Glioma - radiotherapy HeLa Cells Histones - genetics Humans Male Medical prognosis Medicine Medicine & Public Health Metastasis Mutation Neurons - metabolism Neurons - pathology Neurons - radiation effects Neurosciences Oligodendroglia - metabolism Oligodendroglia - pathology Oligodendroglia - radiation effects Original Paper Pathology Pediatrics Phenotype Pons - metabolism Pons - pathology Pons - radiation effects Pons - surgery Prognosis Tumors France Diffuse Intrinsic Pontine Glioma K27M Mutation MYCN Amplification Apparent Diffusion Coefficient Distribute Diffusion Coefficient
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