Effects of 12 weeks of aerobic training on autonomic modulation, mucociliary clearance, and aerobic parameters in patients with COPD

• Published in: International journal of chronic obstructive pulmonary disease Vol. 10; no. Issue 1; pp. 2549 - 2557
• Main Authors: Leite, Marceli Rocha, Ramos, Ercy Mara Cipulo, Kalva-Filho, Carlos Augusto, Freire, Ana Paula Coelho Figueira, de Alencar Silva, Bruna Spolador, Nicolino, Juliana, de Toledo-Arruda, Alessandra Choqueta, Papoti, Marcelo, Vanderlei, Luiz Carlos Marques, Ramos, Dionei
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01-01-2015; Dove Medical Press Ltd; Dove Medical Press
• Subjects: Aerobic exercises; Aerobics; Aged; Analysis; Autonomic Nervous System - physiopathology; Brazil; Cardiovascular System - innervation; Care and treatment; Chronic obstructive pulmonary disease; Exercise; Exercise Test; Exercise Therapy - adverse effects; Exercise Therapy - methods; Exercise Tolerance; Female; Health aspects; Heart Rate; Humans; Lung - innervation; Lung diseases, Obstructive; Male; Middle Aged; Mucociliary Clearance; Mucociliary system; Original Research; Oxygen Consumption; Patients; Physical fitness; Pulmonary Disease, Chronic Obstructive - diagnosis; Pulmonary Disease, Chronic Obstructive - physiopathology; Pulmonary Disease, Chronic Obstructive - therapy; Quality of life; Recovery of Function; Rehabilitation; Respiratory Rate; Spirometry; Time Factors; Treatment Outcome; Brazil; United States > US; exercise; mucociliary clearance; aerobic treatment; COPD
• ISSN: 1178-2005; 1176-9106; 1178-2005
• DOI: 10.2147/COPD.S81363

Patients with chronic obstructive pulmonary disease (COPD) exhibit aerobic function, autonomic nervous system, and mucociliary clearance alterations. These parameters can be attenuated by aerobic training, which can be applied with continuous or interval efforts. However, the possible effects of aerobic training, using progressively both continuous and interval sessions (ie, linear periodization), require further investigation.
To analyze the effects of 12-week aerobic training using continuous and interval sessions on autonomic modulation, mucociliary clearance, and aerobic function in patients with COPD.
Sixteen patients with COPD were divided into an aerobic (continuous and interval) training group (AT) (n=10) and a control group (CG) (n=6). An incremental test (initial speed of 2.0 km·h(-1), constant slope of 3%, and increments of 0.5 km·h(-1) every 2 minutes) was performed. The training group underwent training for 4 weeks at 60% of the peak velocity reached in the incremental test (vVO2peak) (50 minutes of continuous effort), followed by 4 weeks of sessions at 75% of vVO2peak (30 minutes of continuous effort), and 4 weeks of interval training (5×3-minute effort at vVO2peak, separated by 1 minute of passive recovery). Intensities were adjusted through an incremental test performed at the end of each period.
The AT presented an increase in the high frequency index (ms(2)) (P=0.04), peak oxygen uptake (VO2peak) (P=0.01), vVO2peak (P=0.04), and anaerobic threshold (P=0.02). No significant changes were observed in the CG (P>0.21) group. Neither of the groups presented changes in mucociliary clearance after 12 weeks (AT: P=0.94 and CG: P=0.69).
Twelve weeks of aerobic training (continuous and interval sessions) positively influenced the autonomic modulation and aerobic parameters in patients with COPD. However, mucociliary clearance was not affected by aerobic training.