Compositional modelling of immune response and virus transmission dynamics

• Published in: Philosophical transactions of the Royal Society of London. Series A: Mathematical, physical, and engineering sciences Vol. 380; no. 2233; p. 20210307
• Main Authors: Waites, W, Cavaliere, M, Danos, V, Datta, R, Eggo, R M, Hallett, T B, Manheim, D, Panovska-Griffiths, J, Russell, T W, Zarnitsyna, V I
• Format: Journal Article
• Language: English
• Published: England Royal Society, The 03-10-2022; The Royal Society
• Subjects: Computer Science; COVID-19; COVID-19 Testing; Humans; Immunity; COVID-19; epidemics; process calculi; immune response; multi-scale modelling
• ISSN: 1364-503X; 1471-2962
• DOI: 10.1098/rsta.2021.0307

Transmission models for infectious diseases are typically formulated in terms of dynamics between individuals or groups with processes such as disease progression or recovery for each individual captured phenomenologically, without reference to underlying biological processes. Furthermore, the construction of these models is often monolithic: they do not allow one to readily modify the processes involved or include the new ones, or to combine models at different scales. We show how to construct a simple model of immune response to a respiratory virus and a model of transmission using an easily modifiable set of rules allowing further refining and merging the two models together. The immune response model reproduces the expected response curve of PCR testing for COVID-19 and implies a long-tailed distribution of infectiousness reflective of individual heterogeneity. This immune response model, when combined with a transmission model, reproduces the previously reported shift in the population distribution of viral loads along an epidemic trajectory. This article is part of the theme issue 'Technical challenges of modelling real-life epidemics and examples of overcoming these'.