Human interleukin‐1 induces a rapid relaxation of the rabbit isolated mesenteric artery

1 Strips of rabbit superior mesenteric artery, precontracted with phenylephrine, relaxed when exposed to human recombinant interleukin‐1 (IL‐1) of the α or β types. The effect was observed within 10 min, was optimal 32 min after the application of the cytokines and concentration‐dependent (12–290 pm...

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Bibliographic Details
Published in:	British journal of pharmacology Vol. 103; no. 2; pp. 1367 - 1372
Main Authors:	Marceau, François, Petitclerc, Eric, DeBlois, Denis, Pradelles, Philippe, Poubelle, Patrice E.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-06-1991 Nature Publishing
Subjects:	Animals Biological and medical sciences Cardiovascular system Cytokines - pharmacology effect of interleukin‐1 Electric Stimulation Female Humans In Vitro Techniques Interleukin-1 - antagonists & inhibitors Interleukin-1 - pharmacology Interleukin‐1‐induced vascular relaxation Male Medical sciences Mesenteric Arteries - drug effects Monocytes - drug effects Monocytes - physiology Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth, Vascular - drug effects Peptide Fragments - pharmacology Pharmacology. Drug treatments Phenylephrine - pharmacology Prostaglandins - metabolism prostaglandin‐induced vascular relaxation rabbit mesenteric artery Rabbits Vasodilator agents. Cerebral vasodilators Human Prostaglandin Arachidonic acid derivatives Cytokine Rabbit Smooth muscle Lagomorpha Muscle contraction In vitro Vertebrata Mesenteric artery Mammalia Peptide fragment Analog Animal Interleukin 1 Circulatory system
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