Treatment effects in a transgenic mouse model of Alzheimer’s disease: A magnetic resonance spectroscopy study after passive immunization

• Published in: Neuroscience Vol. 259; pp. 94 - 100
• Main Authors: Marjańska, M, Weigand, S.D, Preboske, G, Wengenack, T.M, Chamberlain, R, Curran, G.L, Poduslo, J.F, Garwood, M, Kobayashi, D, Lin, J.C, Jack, C.R
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 14-02-2014; Elsevier
• Subjects: Adult and adolescent clinical studies; Alzheimer Disease - genetics; Alzheimer Disease - immunology; Alzheimer Disease - therapy; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - genetics; Animals; Aspartic Acid - analogs & derivatives; Aspartic Acid - metabolism; Biological and medical sciences; Brain - metabolism; Choline; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Disease Models, Animal; Humans; Immunization, Passive - methods; Inositol; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Transgenic; MRS; Mutation - genetics; myo-inositol; N-acetylaspartate; Neurology; Organic mental disorders. Neuropsychology; Peptide Fragments - metabolism; Presenilin-1 - genetics; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Statistics, Nonparametric; treatment detection; adiabatic half-passage; Cramér-Rao Lower Bounds; FID; tCr; AD; Alzheimer’s disease; adiabatic full-passage; AHP; magnetic resonance spectroscopy; AFP; N-acetylaspartate; myo-inositol; MRS; NAA; treatment detection; mIns; CRLBs; total creatine, sum of creatine and phosphocreatine; wild-type; WT; free induction decay; Animal model; Nervous system diseases; Inositol; Alzheimer disease; Rodentia; Transgenic animal; Cerebral disorder; Vertebrata; Mammalia; Mouse; Central nervous system disease; Degenerative disease
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.11.052

Graphical abstract