Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways

Highlights • Cancer Pain correlates with TRPV1-mediated ERK phosphorylation. • Fufang Kushen Injection reduces thermal hyperalgesia induced by sarcoma. • Fufang Kushen Injection reduces sarcoma growth.

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Bibliographic Details
Published in:	Cancer letters Vol. 355; no. 2; pp. 232 - 241
Main Authors:	Zhao, Zhizheng, Fan, Huiting, Higgins, Tim, Qi, Jia, Haines, Diana, Trivett, Anna, Oppenheim, Joost J, Wei, Hou, Li, Jie, Lin, Hongsheng, Howard, O.M. Zack
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 28-12-2014 Elsevier Limited
Subjects:	Animals Cancer Cancer therapies Capsaicin - metabolism Cell Line, Tumor Chemicals Chemotherapy Cytokines Cytokines - metabolism Drugs, Chinese Herbal - pharmacology ERK Female Fufang Kushen injection Good Manufacturing Practice Heat Hematology, Oncology and Palliative Medicine Hyperalgesia Hyperalgesia - drug therapy Hyperalgesia - metabolism Laboratory animals MAP Kinase Signaling System - drug effects Medical research Metabolic disorders Mice Mice, Inbred C57BL Pain Pharmaceuticals Phosphorylation Phosphorylation - drug effects Proto-Oncogene Proteins c-akt - metabolism Quality control Rodents Sarcoma Sarcoma - complications Sarcoma - drug therapy Sarcoma - enzymology Sarcoma - metabolism TRPV Cation Channels - metabolism TRPV1 China TRPV1 Sarcoma Fufang Kushen injection Hyperalgesia ERK
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Description
Summary:	Highlights • Cancer Pain correlates with TRPV1-mediated ERK phosphorylation. • Fufang Kushen Injection reduces thermal hyperalgesia induced by sarcoma. • Fufang Kushen Injection reduces sarcoma growth.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2014.08.037