CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasis
Oral Diseases (2012) 18, 153–161 Background: Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV+ persons. Previous studies suggest a role for CD8+ T cells against OPC when CD4+ T cells are lost, but enhanced susceptibility to infection occurs when CD8+ T‐cell migration is inhi...
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| Published in: | Oral diseases Vol. 18; no. 2; pp. 153 - 161 |
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| Main Authors: | , , , , , , |
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| Language: | English |
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01-03-2012
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| Abstract | Oral Diseases (2012) 18, 153–161
Background: Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV+ persons. Previous studies suggest a role for CD8+ T cells against OPC when CD4+ T cells are lost, but enhanced susceptibility to infection occurs when CD8+ T‐cell migration is inhibited by reduced tissue E‐cadherin.
Objective: To conduct a longitudinal study of tissue CD8+ T‐cells and E‐cadherin expression before, during, and after the episodes of OPC.
Methods: Oral fungal burden was monitored and tissue was evaluated for CD8+ T cells and E‐cadherin over a 1‐year period in HIV+ persons with a history of, or an acute episode of, OPC.
Results: While longitudinal analyses precluded formal interpretations, point prevalence analyses of the data set revealed that when patients experiencing OPC were successfully treated, tissue E‐cadherin expression was similar to that in patients who had not experienced OPC, and higher numbers of CD8+ T cells were distributed throughout OPC− tissue under normal expression of E‐cadherin.
Conclusion: These results suggest that (1) reduction in tissue E‐cadherin expression in patients with OPC+ is not permanent, and (2) high numbers of CD8+ T cells can be distributed throughout OPC− tissue under normal E‐cadherin expression. Together, these results extend our previous studies and continue to support a role for CD8+ T cells in host defense against OPC. |
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| AbstractList | Oral Diseases (2012) 18, 153–161
Background: Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV+ persons. Previous studies suggest a role for CD8+ T cells against OPC when CD4+ T cells are lost, but enhanced susceptibility to infection occurs when CD8+ T‐cell migration is inhibited by reduced tissue E‐cadherin.
Objective: To conduct a longitudinal study of tissue CD8+ T‐cells and E‐cadherin expression before, during, and after the episodes of OPC.
Methods: Oral fungal burden was monitored and tissue was evaluated for CD8+ T cells and E‐cadherin over a 1‐year period in HIV+ persons with a history of, or an acute episode of, OPC.
Results: While longitudinal analyses precluded formal interpretations, point prevalence analyses of the data set revealed that when patients experiencing OPC were successfully treated, tissue E‐cadherin expression was similar to that in patients who had not experienced OPC, and higher numbers of CD8+ T cells were distributed throughout OPC− tissue under normal expression of E‐cadherin.
Conclusion: These results suggest that (1) reduction in tissue E‐cadherin expression in patients with OPC+ is not permanent, and (2) high numbers of CD8+ T cells can be distributed throughout OPC− tissue under normal E‐cadherin expression. Together, these results extend our previous studies and continue to support a role for CD8+ T cells in host defense against OPC. Background: Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV+ persons. Previous studies suggest a role for CD8+ T cells against OPC when CD4+ T cells are lost, but enhanced susceptibility to infection occurs when CD8+ T-cell migration is inhibited by reduced tissue E-cadherin. Objective: To conduct a longitudinal study of tissue CD8+ T-cells and E-cadherin expression before, during, and after the episodes of OPC. Methods: Oral fungal burden was monitored and tissue was evaluated for CD8+ T cells and E-cadherin over a 1-year period in HIV+ persons with a history of, or an acute episode of, OPC. Results: While longitudinal analyses precluded formal interpretations, point prevalence analyses of the data set revealed that when patients experiencing OPC were successfully treated, tissue E-cadherin expression was similar to that in patients who had not experienced OPC, and higher numbers of CD8+ T cells were distributed throughout OPC- tissue under normal expression of E-cadherin. Conclusion: These results suggest that (1) reduction in tissue E-cadherin expression in patients with OPC+ is not permanent, and (2) high numbers of CD8+ T cells can be distributed throughout OPC- tissue under normal E-cadherin expression. Together, these results extend our previous studies and continue to support a role for CD8+ T cells in host defense against OPC.Original Abstract: Oral Diseases (2012) 18, 153-161 Oral Diseases (2012) 18, 153-161 Background: Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV+ persons. Previous studies suggest a role for CD8+ T cells against OPC when CD4+ T cells are lost, but enhanced susceptibility to infection occurs when CD8+ T-cell migration is inhibited by reduced tissue E-cadherin. Objective: To conduct a longitudinal study of tissue CD8+ T-cells and E-cadherin expression before, during, and after the episodes of OPC. Methods: Oral fungal burden was monitored and tissue was evaluated for CD8+ T cells and E-cadherin over a 1-year period in HIV+ persons with a history of, or an acute episode of, OPC. Results: While longitudinal analyses precluded formal interpretations, point prevalence analyses of the data set revealed that when patients experiencing OPC were successfully treated, tissue E-cadherin expression was similar to that in patients who had not experienced OPC, and higher numbers of CD8+ T cells were distributed throughout OPC- tissue under normal expression of E-cadherin. Conclusion: These results suggest that (1) reduction in tissue E-cadherin expression in patients with OPC+ is not permanent, and (2) high numbers of CD8+ T cells can be distributed throughout OPC- tissue under normal E-cadherin expression. Together, these results extend our previous studies and continue to support a role for CD8+ T cells in host defense against OPC. [PUBLICATION ABSTRACT] Oral Diseases (2012) 18 , 153–161 Background: Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV + persons. Previous studies suggest a role for CD8 + T cells against OPC when CD4 + T cells are lost, but enhanced susceptibility to infection occurs when CD8 + T‐cell migration is inhibited by reduced tissue E‐cadherin. Objective: To conduct a longitudinal study of tissue CD8 + T‐cells and E‐cadherin expression before, during, and after the episodes of OPC. Methods: Oral fungal burden was monitored and tissue was evaluated for CD8 + T cells and E‐cadherin over a 1‐year period in HIV + persons with a history of, or an acute episode of, OPC. Results: While longitudinal analyses precluded formal interpretations, point prevalence analyses of the data set revealed that when patients experiencing OPC were successfully treated, tissue E‐cadherin expression was similar to that in patients who had not experienced OPC, and higher numbers of CD8 + T cells were distributed throughout OPC − tissue under normal expression of E‐cadherin. Conclusion: These results suggest that (1) reduction in tissue E‐cadherin expression in patients with OPC + is not permanent, and (2) high numbers of CD8 + T cells can be distributed throughout OPC − tissue under normal E‐cadherin expression. Together, these results extend our previous studies and continue to support a role for CD8 + T cells in host defense against OPC. Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV(+) persons. Previous studies suggest a role for CD8(+) T cells against OPC when CD4(+) T cells are lost, but enhanced susceptibility to infection occurs when CD8(+) T-cell migration is inhibited by reduced tissue E-cadherin. To conduct a longitudinal study of tissue CD8(+) T-cells and E-cadherin expression before, during, and after the episodes of OPC. Oral fungal burden was monitored and tissue was evaluated for CD8(+) T cells and E-cadherin over a 1-year period in HIV(+) persons with a history of, or an acute episode of, OPC. While longitudinal analyses precluded formal interpretations, point prevalence analyses of the data set revealed that when patients experiencing OPC were successfully treated, tissue E-cadherin expression was similar to that in patients who had not experienced OPC, and higher numbers of CD8(+) T cells were distributed throughout OPC(-) tissue under normal expression of E-cadherin. These results suggest that (1) reduction in tissue E-cadherin expression in patients with OPC(+) is not permanent, and (2) high numbers of CD8(+) T cells can be distributed throughout OPC(-) tissue under normal E-cadherin expression. Together, these results extend our previous studies and continue to support a role for CD8(+) T cells in host defense against OPC. Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV + persons. Previous studies suggest a role for CD8 + T-cells against OPC when CD4 + T-cells are lost, but enhanced susceptibility to infection occurs when CD8 + T-cell migration is inhibited by reduced tissue E-cadherin. |
| Author | Vazquez, JE Quimby, K Zacharek, M Leigh, JE Fidel Jr, PL Lilly, EA McNulty, K |
| AuthorAffiliation | 2 Department of Comprehensive Dentistry, Louisiana State University Health Sciences Center School of Dentistry 4 Department of Otolaryngology, Henry Ford Hospital, Detroit, MI 5 Division of Infectious Diseases, Henry Ford Hospital, Detroit, MI 3 Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry 1 Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, 1100 Florida Avenue New Orleans, Louisiana 70119 |
| AuthorAffiliation_xml | – name: 1 Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry, 1100 Florida Avenue New Orleans, Louisiana 70119 – name: 4 Department of Otolaryngology, Henry Ford Hospital, Detroit, MI – name: 5 Division of Infectious Diseases, Henry Ford Hospital, Detroit, MI – name: 2 Department of Comprehensive Dentistry, Louisiana State University Health Sciences Center School of Dentistry – name: 3 Center of Excellence in Oral and Craniofacial Biology, Louisiana State University Health Sciences Center School of Dentistry |
| Author_xml | – sequence: 1 givenname: K surname: Quimby fullname: Quimby, K organization: Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences, Center School of Dentistry, New Orleans, LA – sequence: 2 givenname: EA surname: Lilly fullname: Lilly, EA organization: Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences, Center School of Dentistry, New Orleans, LA – sequence: 3 givenname: M surname: Zacharek fullname: Zacharek, M organization: Department of Otolaryngology, Henry Ford Hospital, Detroit, MI – sequence: 4 givenname: K surname: McNulty fullname: McNulty, K organization: Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences, Center School of Dentistry, New Orleans, LA – sequence: 5 givenname: JE surname: Leigh fullname: Leigh, JE organization: Department of Comprehensive Dentistry, Louisiana State University Health Sciences Center, School of Dentistry, New Orleans, LA – sequence: 6 givenname: JE surname: Vazquez fullname: Vazquez, JE organization: Division of Infectious Diseases, Henry Ford Hospital, Detroit, MI, USA – sequence: 7 givenname: PL surname: Fidel Jr fullname: Fidel Jr, PL organization: Department of Oral and Craniofacial Biology, Louisiana State University Health Sciences, Center School of Dentistry, New Orleans, LA |
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| Cites_doi | 10.1128/AAC.43.8.2038 10.1111/j.1600-0714.1992.tb00994.x 10.1128/IAI.73.6.3659-3667.2005 10.1086/317944 10.1128/IAI.71.2.956-963.2003 10.1002/eji.200737409 10.1093/infdis/123.4.371 10.1002/eji.200839102 10.1016/0030-4220(92)90185-S 10.1128/IAI.00054-07 10.1097/00042560-199812010-00008 10.1046/j.1365-2958.1999.01590.x 10.1111/j.1601-0825.2000.tb00106.x 10.1086/514571 10.1016/S0162-3109(99)00035-1 10.1086/315872 10.1056/NEJM199803263381301 10.1084/jem.20081463 10.1097/00002030-199111000-00009 10.1093/clinids/21.4.897 10.1046/j.0902-0055.2001.00080.x 10.1016/j.trsl.2006.11.006 10.1128/iai.59.12.4647-4654.1991 10.1016/0167-5699(95)80147-2 10.1046/j.1523-1747.1999.00747.x 10.1016/S0966-842X(01)02094-7 10.1111/j.1348-0421.2007.tb04008.x 10.1056/NEJM198408093110602 10.1086/314871 |
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| References | Conti HR, Shen F, Nayyar N et al (2009). Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med 206: 299-311. Dodd CL, Greenspan D, Katz MH, Westenhouse JL, Feigal DW, Greenspan JS (1991). Oral candidiasis in HIV infection: pseudomembranous and erythematous candidiasis show similar rates of progression to AIDS. AIDS 5: 1339-1343. Klein RS, Harris CA, Small CB, Moll B, Lesser M, Friedland GH (1984). Oral candidiasis in high-risk patients as the initial manifestation of the acquired immunodeficiency syndrome. N Engl J Med 311: 354-357. Clift RA (1984). Candidiasis in the transplant patient. Am J Med 77(Suppl. 4D): 34-38. Slavinsky J III, Myers T, Swoboda RK, Leigh JE, Hager S, Fidel PL Jr (2002). Th1/Th2 cytokine profiles in saliva of HIV-positive smokers with oropharyngeal candidiasis. Oral Microbiol Immunol 17: 38-43. Myers TA, Leigh JE, Arribas A et al (2003). Immunohistochemical evaluation of T cells in oral lesions from human immunodeficiency virus-positive persons with oropharyngeal candidiasis. Infect Immunol 71: 956-963. Reichart PA, Samaranayake LP, Philipsen HP (2000). Pathology and clinical correlates in oral candidiasis and its variants: a review. Oral Dis 6: 85-91. Villar CC, Kashleva H, Nobile CJ, Mitchell AP, Dongari-Bagtzoglou A (2007). Mucosal tissue invasion by Candida albicans is associated with E-cadherin degradation, mediated by transcription factor Rim101p and Protease Sap5p. Infect Immunol 75: 2126-2135. Fichtenbaum CJ, Powderly W (1998). Refratory mucosal Candidiasis in patients with human immunodeficiency virus infection. Clin Infect Dis 26: 556-565. Zelante T, De Luca A, D'Angelo C, Moretti S, Romani L (2009). IL-17/Th17 in antifunal immunity: what's new? Eur J Immunol 39: 645-648. Leigh JE, Steele C, Wormley FL Jr et al (1998). Th1/Th2 cytokine expression in saliva of HIV-positive and HIV-negative individuals: A pilot study in HIV-positive individuals with oropharyngeal candidiasis. J Acq Immun Defic Syndr Human Retrovirol 19: 373-380. Korting HC, Schaller M, Eder G, Hamm G, Böhmer U, Hube B (1999). Effects of human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV-infected patients. Antimicrob Agents Chemother 43: 2038-2042. Hogg N, Berlin C (1995). Structure and function of adhesion receptors in leukocyte trafficking. Immunol Today 16: 327-330. Matsuzaki G, Umemura M (2007). Interleukin-17 as an effector molecule of innate and acquired immunity against infections. Microbiol Immunol 51: 1139-1147. Steele C, Leigh JE, Swoboda RK, Fidel PL Jr (2000). Growth inhibition of Candida by human oral epithelial cells. J Infect Dis 182: 1479-1485. Laskaris G, Hadjivassiliou M, Stratigos J (1992). Oral signs and symptoms in 160 Greek HIV-infected patients. J Oral Pathol 21: 120-123. Romani L, Mocci S, Bietta C, Lanfaloni L, Puccetti P, Bistoni F (1991). Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Th1 responses with acquired resistance. Infect Immunol 59: 4647-4654. Macher AM (1988). The pathology of AIDS. Pub Health Rep 103: 246-254. Cassone A, De Bernardis F, Torosantucci A, Tacconelli E, Tumbarello M, Cauda R (1999). In vitro and in vivo anticandidal activity of human immunodeficiency virus protease inhibitors. J Infect Dis 180: 448-453. Palella FJ Jr, Delaney KM, Moorman AC et al (1998). Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 338: 853-860. Fisher-Hoch SP, Hutwagner L (1995). Opportunistic candidiasis: an epidemic of the 1980s. Clin Infect Dis 21: 897-904. Greenspan JS, Barr CE, Sciubba JJ, Winkler JR (1992). Oral manifestations of HIV infection: definitions, diagnostic criteria and principles of therapy. Oral Surg Oral Med Oral Pathol 73: 142-144. Frank CF, Hostetter MK (2007). Cleavage of E-cadherin: a mechanism for disruption of the intestinal epithelial barrier by Candida albicans. Transl Res 149: 211-222. Borg-von Zepelin M, Meyer I, Thomssen R et al (1999). HIV-Protease inhibitors reduce cell adherence of Candida albicans strains by inhibition of yeast secreted aspartic proteases. J Invest Dermatol 113: 747-751. Gruber A, Speth C, Lukasser-Vogl E et al (1999). Human immunodeficiency virus type 1 protease inhibitor attenuates Candida albicans virulence properties in vitro. Immunopharmacology 41: 227-234. Leigh JE, Barousse M, Swoboda RK et al (2001). Candida-specific systemic cell-mediated immune reactivities in HIV-infected persons with and without mucosal candidiaisis. J Infect Dis 183: 277-285. Zelante T, De Luca A, Bonifazi P et al (2007). IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol 37: 2680-2682. Calderone RA, Fonzi WA (2001). Virulence factors of Candida albicans. Trends Microbiol 9: 327-335. McNulty KM, Plianrungsi J, Leigh JE, Mercante DE, Fidel PL (2005). Characterization of the CD8+ T-cells and microenvironment in oral lesions of HIV-infected persons with oropharyngeal candidiasis. Infect Immunol 73: 3659-3667. Schaller M, Korting HC, Schäfer W, Bastert J, Chen W, Hube B (1999). Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis. Mol Microbiol 34: 169-180. Knight L, Fletcher J (1971). Growth of Candida albicans in saliva: stimulation by glucose associated with antibiotics, corticosteriods and diabetes mellitus. J Infect Dis 123: 371-377. 1998; 26 2002; 17 2001; 183 2007; 149 1991; 59 2000; 6 1995; 16 1988; 103 1998; 338 1999; 43 1971; 123 1999; 41 2007; 51 2003; 71 2007; 75 1992; 73 2007; 37 1991; 5 1998; 19 1984; 311 1984; 77 2001; 9 1999; 180 1995; 21 2005; 73 2000; 182 1999; 34 1999; 113 2009; 206 1992; 21 1988 2009; 39 18094532 - Microbiol Immunol. 2007;51(12):1139-47 10702784 - Oral Dis. 2000 Mar;6(2):85-91 6738653 - N Engl J Med. 1984 Aug 9;311(6):354-8 9524822 - Clin Infect Dis. 1998 Mar;26(3):556-65 10428651 - Immunopharmacology. 1999 Apr;41(3):227-34 17899546 - Eur J Immunol. 2007 Oct;37(10):2695-706 10540295 - Mol Microbiol. 1999 Oct;34(1):169-80 11860554 - Oral Microbiol Immunol. 2002 Feb;17(1):38-43 12540578 - Infect Immun. 2003 Feb;71(2):956-63 10571729 - J Invest Dermatol. 1999 Nov;113(5):747-51 11120933 - J Infect Dis. 2001 Jan 15;183(2):277-285 7576066 - Immunol Today. 1995 Jul;16(7):327-30 9833746 - J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 1;19(4):373-80 11435107 - Trends Microbiol. 2001 Jul;9(7):327-35 19204111 - J Exp Med. 2009 Feb 16;206(2):299-311 1532234 - Oral Surg Oral Med Oral Pathol. 1992 Feb;73(2):142-4 10395861 - J Infect Dis. 1999 Aug;180(2):448-53 17383595 - Transl Res. 2007 Apr;149(4):211-22 17339363 - Infect Immun. 2007 May;75(5):2126-35 8645837 - Clin Infect Dis. 1995 Oct;21(4):897-904 5110739 - J Infect Dis. 1971 Apr;123(4):371-7 11023471 - J Infect Dis. 2000 Nov;182(5):1479-85 6388324 - Am J Med. 1984 Oct 30;77(4D):34-8 2836878 - Public Health Rep. 1988 May-Jun;103(3):246-54 15908395 - Infect Immun. 2005 Jun;73(6):3659-67 10428932 - Antimicrob Agents Chemother. 1999 Aug;43(8):2038-42 1316436 - J Oral Pathol Med. 1992 Mar;21(3):120-3 19283705 - Eur J Immunol. 2009 Mar;39(3):645-8 1768382 - AIDS. 1991 Nov;5(11):1339-43 1682265 - Infect Immun. 1991 Dec;59(12):4647-54 9516219 - N Engl J Med. 1998 Mar 26;338(13):853-60 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 Macher AM (e_1_2_7_20_1) 1988; 103 Odds FC (e_1_2_7_24_1) 1988 e_1_2_7_18_1 e_1_2_7_17_1 e_1_2_7_2_1 e_1_2_7_15_1 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 e_1_2_7_10_1 e_1_2_7_26_1 Romani L (e_1_2_7_27_1) 1991; 59 e_1_2_7_28_1 e_1_2_7_29_1 e_1_2_7_30_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_32_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_22_1 e_1_2_7_21_1 Korting HC (e_1_2_7_16_1) 1999; 43 Clift RA (e_1_2_7_5_1) 1984; 77 |
| References_xml | – start-page: 104 year: 1988 end-page: 110 – volume: 113 start-page: 747 year: 1999 end-page: 751 article-title: HIV‐Protease inhibitors reduce cell adherence of strains by inhibition of yeast secreted aspartic proteases publication-title: J Invest Dermatol – volume: 73 start-page: 142 year: 1992 end-page: 144 article-title: Oral manifestations of HIV infection: definitions, diagnostic criteria and principles of therapy publication-title: Oral Surg Oral Med Oral Pathol – volume: 311 start-page: 354 year: 1984 end-page: 357 article-title: Oral candidiasis in high‐risk patients as the initial manifestation of the acquired immunodeficiency syndrome publication-title: N Engl J Med – volume: 39 start-page: 645 year: 2009 end-page: 648 article-title: IL‐17/Th17 in antifunal immunity: what’s new? publication-title: Eur J Immunol – volume: 9 start-page: 327 year: 2001 end-page: 335 article-title: Virulence factors of publication-title: Trends Microbiol – volume: 21 start-page: 897 year: 1995 end-page: 904 article-title: Opportunistic candidiasis: an epidemic of the 1980s publication-title: Clin Infect Dis – volume: 17 start-page: 38 year: 2002 end-page: 43 article-title: Th1/Th2 cytokine profiles in saliva of HIV‐positive smokers with oropharyngeal candidiasis publication-title: Oral Microbiol Immunol – volume: 103 start-page: 246 year: 1988 end-page: 254 article-title: The pathology of AIDS publication-title: Pub Health Rep – volume: 73 start-page: 3659 year: 2005 end-page: 3667 article-title: Characterization of the CD8+ T‐cells and microenvironment in oral lesions of HIV‐infected persons with oropharyngeal candidiasis publication-title: Infect Immunol – volume: 75 start-page: 2126 year: 2007 end-page: 2135 article-title: Mucosal tissue invasion by is associated with E‐cadherin degradation, mediated by transcription factor Rim101p and Protease Sap5p publication-title: Infect Immunol – volume: 19 start-page: 373 year: 1998 end-page: 380 article-title: Th1/Th2 cytokine expression in saliva of HIV‐positive and HIV‐negative individuals: A pilot study in HIV‐positive individuals with oropharyngeal candidiasis publication-title: J Acq Immun Defic Syndr Human Retrovirol – volume: 183 start-page: 277 year: 2001 end-page: 285 article-title: ‐specific systemic cell‐mediated immune reactivities in HIV‐infected persons with and without mucosal candidiaisis publication-title: J Infect Dis – volume: 77 start-page: 34 issue: Suppl. 4D year: 1984 end-page: 38 article-title: Candidiasis in the transplant patient publication-title: Am J Med – volume: 338 start-page: 853 year: 1998 end-page: 860 article-title: Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators publication-title: N Engl J Med – volume: 71 start-page: 956 year: 2003 end-page: 963 article-title: Immunohistochemical evaluation of T cells in oral lesions from human immunodeficiency virus‐positive persons with oropharyngeal candidiasis publication-title: Infect Immunol – volume: 149 start-page: 211 year: 2007 end-page: 222 article-title: Cleavage of E‐cadherin: a mechanism for disruption of the intestinal epithelial barrier by publication-title: Transl Res – volume: 5 start-page: 1339 year: 1991 end-page: 1343 article-title: Oral candidiasis in HIV infection: pseudomembranous and erythematous candidiasis show similar rates of progression to AIDS publication-title: AIDS – volume: 16 start-page: 327 year: 1995 end-page: 330 article-title: Structure and function of adhesion receptors in leukocyte trafficking publication-title: Immunol Today – volume: 6 start-page: 85 year: 2000 end-page: 91 article-title: Pathology and clinical correlates in oral candidiasis and its variants: a review publication-title: Oral Dis – volume: 41 start-page: 227 year: 1999 end-page: 234 article-title: Human immunodeficiency virus type 1 protease inhibitor attenuates virulence properties publication-title: Immunopharmacology – volume: 34 start-page: 169 year: 1999 end-page: 180 article-title: Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis publication-title: Mol Microbiol – volume: 21 start-page: 120 year: 1992 end-page: 123 article-title: Oral signs and symptoms in 160 Greek HIV‐infected patients publication-title: J Oral Pathol – volume: 51 start-page: 1139 year: 2007 end-page: 1147 article-title: Interleukin‐17 as an effector molecule of innate and acquired immunity against infections publication-title: Microbiol Immunol – volume: 206 start-page: 299 year: 2009 end-page: 311 article-title: Th17 cells and IL‐17 receptor signaling are essential for mucosal host defense against oral candidiasis publication-title: J Exp Med – volume: 59 start-page: 4647 year: 1991 end-page: 4654 article-title: Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Th1 responses with acquired resistance publication-title: Infect Immunol – volume: 26 start-page: 556 year: 1998 end-page: 565 article-title: Refratory mucosal Candidiasis in patients with human immunodeficiency virus infection publication-title: Clin Infect Dis – volume: 182 start-page: 1479 year: 2000 end-page: 1485 article-title: Growth inhibition of by human oral epithelial cells publication-title: J Infect Dis – volume: 123 start-page: 371 year: 1971 end-page: 377 article-title: Growth of in saliva: stimulation by glucose associated with antibiotics, corticosteriods and diabetes mellitus publication-title: J Infect Dis – volume: 37 start-page: 2680 year: 2007 end-page: 2682 article-title: IL‐23 and the Th17 pathway promote inflammation and impair antifungal immune resistance publication-title: Eur J Immunol – volume: 43 start-page: 2038 year: 1999 end-page: 2042 article-title: Effects of human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on activities of secreted aspartyl proteinases of isolates from HIV‐infected patients publication-title: Antimicrob Agents Chemother – volume: 180 start-page: 448 year: 1999 end-page: 453 article-title: and anticandidal activity of human immunodeficiency virus protease inhibitors publication-title: J Infect Dis – volume: 43 start-page: 2038 year: 1999 ident: e_1_2_7_16_1 article-title: Effects of human immunodeficiency virus (HIV) proteinase inhibitors saquinavir and indinavir on in vitro activities of secreted aspartyl proteinases of Candida albicans isolates from HIV‐infected patients publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.43.8.2038 contributor: fullname: Korting HC – volume: 103 start-page: 246 year: 1988 ident: e_1_2_7_20_1 article-title: The pathology of AIDS publication-title: Pub Health Rep contributor: fullname: Macher AM – ident: e_1_2_7_17_1 doi: 10.1111/j.1600-0714.1992.tb00994.x – ident: e_1_2_7_22_1 doi: 10.1128/IAI.73.6.3659-3667.2005 – ident: e_1_2_7_19_1 doi: 10.1086/317944 – ident: e_1_2_7_23_1 doi: 10.1128/IAI.71.2.956-963.2003 – ident: e_1_2_7_32_1 doi: 10.1002/eji.200737409 – start-page: 104 volume-title: Candida and candidosis year: 1988 ident: e_1_2_7_24_1 contributor: fullname: Odds FC – ident: e_1_2_7_15_1 doi: 10.1093/infdis/123.4.371 – ident: e_1_2_7_33_1 doi: 10.1002/eji.200839102 – ident: e_1_2_7_11_1 doi: 10.1016/0030-4220(92)90185-S – ident: e_1_2_7_31_1 doi: 10.1128/IAI.00054-07 – ident: e_1_2_7_18_1 doi: 10.1097/00042560-199812010-00008 – ident: e_1_2_7_28_1 doi: 10.1046/j.1365-2958.1999.01590.x – ident: e_1_2_7_26_1 doi: 10.1111/j.1601-0825.2000.tb00106.x – ident: e_1_2_7_8_1 doi: 10.1086/514571 – ident: e_1_2_7_12_1 doi: 10.1016/S0162-3109(99)00035-1 – ident: e_1_2_7_30_1 doi: 10.1086/315872 – ident: e_1_2_7_25_1 doi: 10.1056/NEJM199803263381301 – ident: e_1_2_7_6_1 doi: 10.1084/jem.20081463 – ident: e_1_2_7_7_1 doi: 10.1097/00002030-199111000-00009 – ident: e_1_2_7_9_1 doi: 10.1093/clinids/21.4.897 – ident: e_1_2_7_29_1 doi: 10.1046/j.0902-0055.2001.00080.x – ident: e_1_2_7_10_1 doi: 10.1016/j.trsl.2006.11.006 – volume: 59 start-page: 4647 year: 1991 ident: e_1_2_7_27_1 article-title: Th1 and Th2 cytokine secretion patterns in murine candidiasis: association of Th1 responses with acquired resistance publication-title: Infect Immunol doi: 10.1128/iai.59.12.4647-4654.1991 contributor: fullname: Romani L – ident: e_1_2_7_13_1 doi: 10.1016/0167-5699(95)80147-2 – ident: e_1_2_7_2_1 doi: 10.1046/j.1523-1747.1999.00747.x – volume: 77 start-page: 34 issue: 4 year: 1984 ident: e_1_2_7_5_1 article-title: Candidiasis in the transplant patient publication-title: Am J Med contributor: fullname: Clift RA – ident: e_1_2_7_3_1 doi: 10.1016/S0966-842X(01)02094-7 – ident: e_1_2_7_21_1 doi: 10.1111/j.1348-0421.2007.tb04008.x – ident: e_1_2_7_14_1 doi: 10.1056/NEJM198408093110602 – ident: e_1_2_7_4_1 doi: 10.1086/314871 |
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| Snippet | Oral Diseases (2012) 18, 153–161
Background: Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV+ persons. Previous studies suggest a... Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV(+) persons. Previous studies suggest a role for CD8(+) T cells against OPC when CD4(+)... Oral Diseases (2012) 18 , 153–161 Background: Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV + persons. Previous studies suggest a... Oral Diseases (2012) 18, 153-161 Background: Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV+ persons. Previous studies suggest a role... Background: Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV+ persons. Previous studies suggest a role for CD8+ T cells against OPC... Oropharyngeal candidiasis (OPC) is the most common oral infection in HIV + persons. Previous studies suggest a role for CD8 + T-cells against OPC when CD4 +... |
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| SubjectTerms | Adult African Americans Analysis of Variance Antifungal Agents - therapeutic use Antiretroviral Therapy, Highly Active Cadherins - biosynthesis Cadherins - physiology Candida - isolation & purification Candidiasis Candidiasis, Oral - complications Candidiasis, Oral - drug therapy Candidiasis, Oral - immunology CD4 antigen CD4 Lymphocyte Count CD8 antigen CD8+ T cells CD8-Positive T-Lymphocytes - immunology Cell adhesion & migration Cell migration Cell Movement Colony Count, Microbial Colorectal cancer Data processing E-Cadherin Female HIV HIV Infections - complications HIV Infections - drug therapy Host-Pathogen Interactions - immunology Human immunodeficiency virus Humans Immunophenotyping Longitudinal Studies Lymphocytes Lymphocytes T Male Middle Aged Mouth Mucosa - immunology Mouth Mucosa - microbiology Oral infection oropharyngeal candidiasis Saliva - immunology Saliva - microbiology Statistics, Nonparametric |
| Title | CD8 T cells and E-cadherin in host responses against oropharyngeal candidiasis |
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