Global, regional, and national burden of migraine and tension-type headache, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

Through the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health concern. We aimed to use data from the GBD 2016 study to provide new estimates for prevalence and years of life lived with disability (YLDs) for migraine and tension-...

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Published in:Lancet neurology Vol. 17; no. 11; pp. 954 - 976
Main Authors: Stovner, Lars Jacob, Nichols, Emma, Steiner, Timothy J, Abd-Allah, Foad, Abdelalim, Ahmed, Al-Raddadi, Rajaa M, Ansha, Mustafa Geleto, Barac, Aleksandra, Bensenor, Isabela M, Doan, Linh Phuong, Edessa, Dumessa, Endres, Matthias, Foreman, Kyle J, Gankpe, Fortune Gbetoho, Gopalkrishna, Gururaj, Goulart, Alessandra C, Gupta, Rahul, Hankey, Graeme J, Hay, Simon I, Hegazy, Mohamed I, Hilawe, Esayas Haregot, Kasaeian, Amir, Kassa, Dessalegn H, Khalil, Ibrahim, Khang, Young-Ho, Khubchandan, Jagdish, Kim, Yun Jin, Kokubo, Yoshihiro, Mohammed, Mohammed A, Mokdad, Ali H, Moradi-Lakeh, Maziar, Nguyen, Huong Lan Thi, Nirayo, Yirga Legesse, Qorbani, Mostafa, Ranta, Anna, Roba, Kedir T, Safiri, Saeid, Santos, Itamar S, Satpathy, Maheswar, Sawhney, Monika, Shiferaw, Mekonnen Sisay, Shiue, Ivy, Smith, Mari, Szoeke, Cassandra E I, Truong, Nu Thi, Venketasubramanian, Narayanaswamy, weldegwergs, Kidu gidey, Westerman, Ronny, Wijeratne, Tissa, Tran, Bach Xuan, Yonemoto, Naohiro, Feigin, Valery L, Vos, Theo, Murray, Christopher J L
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-11-2018
Elsevier Limited
Lancet Pub. Group
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Abstract Through the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health concern. We aimed to use data from the GBD 2016 study to provide new estimates for prevalence and years of life lived with disability (YLDs) for migraine and tension-type headache and to present the methods and results in an accessible way for clinicians and researchers of headache disorders. Data were derived from population-based cross-sectional surveys on migraine and tension-type headache. Prevalence for each sex and 5-year age group interval (ie, age 5 years to ≥95 years) at different time points from 1990 and 2016 in all countries and GBD regions were estimated using a Bayesian meta-regression model. Disease burden measured in YLDs was calculated from prevalence and average time spent with headache multiplied by disability weights (a measure of the relative severity of the disabling consequence of a disease). The burden stemming from medication overuse headache, which was included in earlier iterations of GBD as a separate cause, was subsumed as a sequela of either migraine or tension-type headache. Because no deaths were assigned to headaches as the underlying cause, YLDs equate to disability-adjusted life-years (DALYs). We also analysed results on the basis of the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility. Almost three billion individuals were estimated to have a migraine or tension-type headache in 2016: 1·89 billion (95% uncertainty interval [UI] 1·71–2·10) with tension-type headache and 1·04 billion (95% UI 1·00–1·09) with migraine. However, because migraine had a much higher disability weight than tension-type headache, migraine caused 45·1 million (95% UI 29·0–62·8) and tension-type headache only 7·2 million (95% UI 4·6–10·5) YLDs globally in 2016. The headaches were most burdensome in women between ages 15 and 49 years, with migraine causing 20·3 million (95% UI 12·9–28·5) and tension-type headache 2·9 million (95% UI 1·8–4·2) YLDs in 2016, which was 11·2% of all YLDs in this age group and sex. Age-standardised DALYs for each headache type showed a small increase as SDI increased. Although current estimates are based on limited data, our study shows that headache disorders, and migraine in particular, are important causes of disability worldwide, and deserve greater attention in health policy debates and research resource allocation. Future iterations of this study, based on sources from additional countries and with less methodological heterogeneity, should help to provide stronger evidence of the need for action. Bill & Melinda Gates Foundation.
AbstractList Through the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health concern. We aimed to use data from the GBD 2016 study to provide new estimates for prevalence and years of life lived with disability (YLDs) for migraine and tension-type headache and to present the methods and results in an accessible way for clinicians and researchers of headache disorders. Data were derived from population-based cross-sectional surveys on migraine and tension-type headache. Prevalence for each sex and 5-year age group interval (ie, age 5 years to ≥95 years) at different time points from 1990 and 2016 in all countries and GBD regions were estimated using a Bayesian meta-regression model. Disease burden measured in YLDs was calculated from prevalence and average time spent with headache multiplied by disability weights (a measure of the relative severity of the disabling consequence of a disease). The burden stemming from medication overuse headache, which was included in earlier iterations of GBD as a separate cause, was subsumed as a sequela of either migraine or tension-type headache. Because no deaths were assigned to headaches as the underlying cause, YLDs equate to disability-adjusted life-years (DALYs). We also analysed results on the basis of the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility. Almost three billion individuals were estimated to have a migraine or tension-type headache in 2016: 1·89 billion (95% uncertainty interval [UI] 1·71-2·10) with tension-type headache and 1·04 billion (95% UI 1·00-1·09) with migraine. However, because migraine had a much higher disability weight than tension-type headache, migraine caused 45·1 million (95% UI 29·0-62·8) and tension-type headache only 7·2 million (95% UI 4·6-10·5) YLDs globally in 2016. The headaches were most burdensome in women between ages 15 and 49 years, with migraine causing 20·3 million (95% UI 12·9-28·5) and tension-type headache 2·9 million (95% UI 1·8-4·2) YLDs in 2016, which was 11·2% of all YLDs in this age group and sex. Age-standardised DALYs for each headache type showed a small increase as SDI increased. Although current estimates are based on limited data, our study shows that headache disorders, and migraine in particular, are important causes of disability worldwide, and deserve greater attention in health policy debates and research resource allocation. Future iterations of this study, based on sources from additional countries and with less methodological heterogeneity, should help to provide stronger evidence of the need for action. Bill & Melinda Gates Foundation.
BACKGROUNDThrough the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health concern. We aimed to use data from the GBD 2016 study to provide new estimates for prevalence and years of life lived with disability (YLDs) for migraine and tension-type headache and to present the methods and results in an accessible way for clinicians and researchers of headache disorders. METHODSData were derived from population-based cross-sectional surveys on migraine and tension-type headache. Prevalence for each sex and 5-year age group interval (ie, age 5 years to ≥95 years) at different time points from 1990 and 2016 in all countries and GBD regions were estimated using a Bayesian meta-regression model. Disease burden measured in YLDs was calculated from prevalence and average time spent with headache multiplied by disability weights (a measure of the relative severity of the disabling consequence of a disease). The burden stemming from medication overuse headache, which was included in earlier iterations of GBD as a separate cause, was subsumed as a sequela of either migraine or tension-type headache. Because no deaths were assigned to headaches as the underlying cause, YLDs equate to disability-adjusted life-years (DALYs). We also analysed results on the basis of the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility. FINDINGSAlmost three billion individuals were estimated to have a migraine or tension-type headache in 2016: 1·89 billion (95% uncertainty interval [UI] 1·71-2·10) with tension-type headache and 1·04 billion (95% UI 1·00-1·09) with migraine. However, because migraine had a much higher disability weight than tension-type headache, migraine caused 45·1 million (95% UI 29·0-62·8) and tension-type headache only 7·2 million (95% UI 4·6-10·5) YLDs globally in 2016. The headaches were most burdensome in women between ages 15 and 49 years, with migraine causing 20·3 million (95% UI 12·9-28·5) and tension-type headache 2·9 million (95% UI 1·8-4·2) YLDs in 2016, which was 11·2% of all YLDs in this age group and sex. Age-standardised DALYs for each headache type showed a small increase as SDI increased. INTERPRETATIONAlthough current estimates are based on limited data, our study shows that headache disorders, and migraine in particular, are important causes of disability worldwide, and deserve greater attention in health policy debates and research resource allocation. Future iterations of this study, based on sources from additional countries and with less methodological heterogeneity, should help to provide stronger evidence of the need for action. FUNDINGBill & Melinda Gates Foundation.
Summary Background Through the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health concern. We aimed to use data from the GBD 2016 study to provide new estimates for prevalence and years of life lived with disability (YLDs) for migraine and tension-type headache and to present the methods and results in an accessible way for clinicians and researchers of headache disorders. Methods Data were derived from population-based cross-sectional surveys on migraine and tension-type headache. Prevalence for each sex and 5-year age group interval (ie, age 5 years to ≥95 years) at different time points from 1990 and 2016 in all countries and GBD regions were estimated using a Bayesian meta-regression model. Disease burden measured in YLDs was calculated from prevalence and average time spent with headache multiplied by disability weights (a measure of the relative severity of the disabling consequence of a disease). The burden stemming from medication overuse headache, which was included in earlier iterations of GBD as a separate cause, was subsumed as a sequela of either migraine or tension-type headache. Because no deaths were assigned to headaches as the underlying cause, YLDs equate to disability-adjusted life-years (DALYs). We also analysed results on the basis of the Socio-demographic Index (SDI), a compound measure of income per capita, education, and fertility. Findings Almost three billion individuals were estimated to have a migraine or tension-type headache in 2016: 1·89 billion (95% uncertainty interval [UI] 1·71–2·10) with tension-type headache and 1·04 billion (95% UI 1·00–1·09) with migraine. However, because migraine had a much higher disability weight than tension-type headache, migraine caused 45·1 million (95% UI 29·0–62·8) and tension-type headache only 7·2 million (95% UI 4·6–10·5) YLDs globally in 2016. The headaches were most burdensome in women between ages 15 and 49 years, with migraine causing 20·3 million (95% UI 12·9–28·5) and tension-type headache 2·9 million (95% UI 1·8–4·2) YLDs in 2016, which was 11·2% of all YLDs in this age group and sex. Age-standardised DALYs for each headache type showed a small increase as SDI increased. Interpretation Although current estimates are based on limited data, our study shows that headache disorders, and migraine in particular, are important causes of disability worldwide, and deserve greater attention in health policy debates and research resource allocation. Future iterations of this study, based on sources from additional countries and with less methodological heterogeneity, should help to provide stronger evidence of the need for action. Funding Bill & Melinda Gates Foundation.
Author Westerman, Ronny
Khang, Young-Ho
Smith, Mari
Abdelalim, Ahmed
Sawhney, Monika
Shiferaw, Mekonnen Sisay
Tran, Bach Xuan
Barac, Aleksandra
Nirayo, Yirga Legesse
Doan, Linh Phuong
Kokubo, Yoshihiro
Santos, Itamar S
Mohammed, Mohammed A
weldegwergs, Kidu gidey
Nichols, Emma
Truong, Nu Thi
Murray, Christopher J L
Venketasubramanian, Narayanaswamy
Feigin, Valery L
Szoeke, Cassandra E I
Roba, Kedir T
Hilawe, Esayas Haregot
Shiue, Ivy
Steiner, Timothy J
Edessa, Dumessa
Wijeratne, Tissa
Hankey, Graeme J
Safiri, Saeid
Bensenor, Isabela M
Ansha, Mustafa Geleto
Gankpe, Fortune Gbetoho
Khalil, Ibrahim
Hay, Simon I
Hegazy, Mohamed I
Moradi-Lakeh, Maziar
Nguyen, Huong Lan Thi
Ranta, Anna
Stovner, Lars Jacob
Abd-Allah, Foad
Gopalkrishna, Gururaj
Vos, Theo
Foreman, Kyle J
Satpathy, Maheswar
Kasaeian, Amir
Kim, Yun Jin
Khubchandan, Jagdish
Endres, Matthias
Qorbani, Mostafa
Al-Raddadi, Rajaa M
Gupta, Rahul
Kassa, Dessalegn H
Mokdad, Ali H
Goulart, Alessandra C
Yonemoto, Naohiro
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Khang, Young-Ho
Smith, Mari
Abdelalim, Ahmed
Sawhney, Monika
Shiferaw, Mekonnen Sisay
Tran, Bach Xuan
Barac, Aleksandra
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Kokubo, Yoshihiro
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Mohammed, Mohammed A
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Murray, Christopher J L
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Hay, Simon I
Hegazy, Mohamed I
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Nguyen, Huong Lan Thi
Ranta, Anna
Stovner, Lars Jacob
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Gopalkrishna, Gururaj
Vos, Theo
Foreman, Kyle J
Satpathy, Maheswar
Kasaeian, Amir
Kim, Yun Jin
Khubchandan, Jagdish
Weldegwergs, Kidu Gidey
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Copyright 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.
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2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license 2018
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PublicationDecade 2010
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PublicationTitle Lancet neurology
PublicationTitleAlternate Lancet Neurol
PublicationYear 2018
Publisher Elsevier Ltd
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Lancet Pub. Group
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– name: Elsevier Limited
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Snippet Through the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health concern. We aimed to use...
Summary Background Through the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health...
BACKGROUNDThrough the Global Burden of Diseases, Injuries, and Risk Factors (GBD) studies, headache has emerged as a major global public health concern. We...
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SubjectTerms Adolescent
Adult
Age
Age Distribution
Aged
Aged, 80 and over
Bayes Theorem
Bayesian analysis
Child
Child, Preschool
Community Health Planning
Cross-Sectional Studies
Disabled Persons
Disease
Epidemiology
Estimates
Female
Global Burden of Disease - methods
Global Health
Headache
Headaches
Humans
Male
Middle Aged
Migraine
Migraine Disorders - economics
Migraine Disorders - epidemiology
Mortality
Prevalence
Public health
PubMed - statistics & numerical data
Resource allocation
Retrospective Studies
Risk factors
Studies
Systematic review
Tension-Type Headache - economics
Tension-Type Headache - epidemiology
Young Adult
Title Global, regional, and national burden of migraine and tension-type headache, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
URI https://dx.doi.org/10.1016/S1474-4422(18)30322-3
https://www.ncbi.nlm.nih.gov/pubmed/30353868
https://www.proquest.com/docview/2120679004
https://search.proquest.com/docview/2125314407
https://pubmed.ncbi.nlm.nih.gov/PMC6191530
Volume 17
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