Alternative splicing in endothelial cells: novel therapeutic opportunities in cancer angiogenesis

Alternative splicing (AS) is a pervasive molecular process generating multiple protein isoforms, from a single gene. It plays fundamental roles during development, differentiation and maintenance of tissue homeostasis, while aberrant AS is considered a hallmark of multiple diseases, including cancer...

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Bibliographic Details
Published in:	Journal of experimental & clinical cancer research Vol. 39; no. 1; pp. 1 - 275
Main Authors:	Di Matteo, Anna, Belloni, Elisa, Pradella, Davide, Cappelletto, Ambra, Volf, Nina, Zacchigna, Serena, Ghigna, Claudia
Format:	Journal Article
Language:	English
Published:	London BioMed Central Ltd 07-12-2020 BioMed Central BMC
Subjects:	Alternative splicing; RNA binding proteins Angiogenesis Anti-angiogenic therapy Cancer Care and treatment Cell adhesion & migration Cell cycle Endothelial cells Endothelium Gene expression Genes Genomes Hemoglobin Hypoxia Protein binding Proteins Review RNA Shear stress Thyroid gland Transcription factors Tumors Vascular biology Vascular endothelial growth factor
Online Access:	Get full text
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