Protocol for the systematic review and meta-analysis of factors associated with non-adherence to antidepressants in depressive disorders in those more than 18 years of age

We have developed a protocol for the systematic review and meta-analysis of the factors associated with nonadherence to antidepressants in depressive patients more than 18 years of age. We will search articles with the databases PubMed- Medline, Scopus, Embase and PsychINFO. All the published litera...

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Published in:	PloS one Vol. 18; no. 2; p. e0281366
Main Authors:	Dhungana, Saraswati, Rijal, Rojal, Regmi, Binit, Bajracharya, Jala Shree, Sharma, Subriddhi, Singh, Sunil, Karn, Nilam, Chapagai, Manisha
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 06-02-2023 Public Library of Science (PLoS)
Subjects:	Adolescent Age Analysis Antidepressants Antidepressants, Tricyclic Antidepressive Agents - therapeutic use Bias Cardiovascular disease Clinical trials Comorbidity Complications and side effects Depression - drug therapy Depression, Mental Depressive Disorder - drug therapy Drug therapy Evaluation Health risks Humans Intervention Medicine and Health Sciences Mental depression Mental disorders Meta-analysis Meta-Analysis as Topic Patient compliance Patient outcomes Patients Physical Sciences Prescription drugs Quality of Life Registered Report Protocol Research and Analysis Methods Systematic review Systematic Reviews as Topic Nepal
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Abstract	We have developed a protocol for the systematic review and meta-analysis of the factors associated with nonadherence to antidepressants in depressive patients more than 18 years of age. We will search articles with the databases PubMed- Medline, Scopus, Embase and PsychINFO. All the published literature reporting factors associated with nonadherence to antidepressants in depressive disorders in patients more than 18 years of age and fulfilling all the eligibility criteria till October 2022 will be included. The data will then be extracted and examined to be included in the systematic review. Finally, we will conduct meta-analysis for factors associated with non-adherence. We will do extensive search on the proposed topic within the available literature and come up with a robust review of factors associated with nonadherence to antidepressants in patients age more than 18 years globally. The evidence generated would assist in designing interventions to address non-adherence in this group of patients leading to better productivity and quality of life.
AbstractList	We have developed a protocol for the systematic review and meta-analysis of the factors associated with nonadherence to antidepressants in depressive patients more than 18 years of age. We will search articles with the databases PubMed- Medline, Scopus, Embase and PsychINFO. All the published literature reporting factors associated with nonadherence to antidepressants in depressive disorders in patients more than 18 years of age and fulfilling all the eligibility criteria till October 2022 will be included. The data will then be extracted and examined to be included in the systematic review. Finally, we will conduct meta-analysis for factors associated with non-adherence. We will do extensive search on the proposed topic within the available literature and come up with a robust review of factors associated with nonadherence to antidepressants in patients age more than 18 years globally. The evidence generated would assist in designing interventions to address non-adherence in this group of patients leading to better productivity and quality of life. Objective We have developed a protocol for the systematic review and meta-analysis of the factors associated with nonadherence to antidepressants in depressive patients more than 18 years of age. Methods We will search articles with the databases PubMed- Medline, Scopus, Embase and PsychINFO. All the published literature reporting factors associated with nonadherence to antidepressants in depressive disorders in patients more than 18 years of age and fulfilling all the eligibility criteria till October 2022 will be included. The data will then be extracted and examined to be included in the systematic review. Finally, we will conduct meta-analysis for factors associated with non-adherence. Conclusion We will do extensive search on the proposed topic within the available literature and come up with a robust review of factors associated with nonadherence to antidepressants in patients age more than 18 years globally. The evidence generated would assist in designing interventions to address non-adherence in this group of patients leading to better productivity and quality of life. ObjectiveWe have developed a protocol for the systematic review and meta-analysis of the factors associated with nonadherence to antidepressants in depressive patients more than 18 years of age.MethodsWe will search articles with the databases PubMed- Medline, Scopus, Embase and PsychINFO. All the published literature reporting factors associated with nonadherence to antidepressants in depressive disorders in patients more than 18 years of age and fulfilling all the eligibility criteria till October 2022 will be included. The data will then be extracted and examined to be included in the systematic review. Finally, we will conduct meta-analysis for factors associated with non-adherence.ConclusionWe will do extensive search on the proposed topic within the available literature and come up with a robust review of factors associated with nonadherence to antidepressants in patients age more than 18 years globally. The evidence generated would assist in designing interventions to address non-adherence in this group of patients leading to better productivity and quality of life. We have developed a protocol for the systematic review and meta-analysis of the factors associated with nonadherence to antidepressants in depressive patients more than 18 years of age. We will search articles with the databases PubMed- Medline, Scopus, Embase and PsychINFO. All the published literature reporting factors associated with nonadherence to antidepressants in depressive disorders in patients more than 18 years of age and fulfilling all the eligibility criteria till October 2022 will be included. The data will then be extracted and examined to be included in the systematic review. Finally, we will conduct meta-analysis for factors associated with non-adherence. We will do extensive search on the proposed topic within the available literature and come up with a robust review of factors associated with nonadherence to antidepressants in patients age more than 18 years globally. The evidence generated would assist in designing interventions to address non-adherence in this group of patients leading to better productivity and quality of life. Objective We have developed a protocol for the systematic review and meta-analysis of the factors associated with nonadherence to antidepressants in depressive patients more than 18 years of age. Methods We will search articles with the databases PubMed- Medline, Scopus, Embase and PsychINFO. All the published literature reporting factors associated with nonadherence to antidepressants in depressive disorders in patients more than 18 years of age and fulfilling all the eligibility criteria till October 2022 will be included. The data will then be extracted and examined to be included in the systematic review. Finally, we will conduct meta-analysis for factors associated with non-adherence. Conclusion We will do extensive search on the proposed topic within the available literature and come up with a robust review of factors associated with nonadherence to antidepressants in patients age more than 18 years globally. The evidence generated would assist in designing interventions to address non-adherence in this group of patients leading to better productivity and quality of life.
Audience	Academic
Author	Chapagai, Manisha Regmi, Binit Sharma, Subriddhi Rijal, Rojal Bajracharya, Jala Shree Dhungana, Saraswati Singh, Sunil Karn, Nilam
AuthorAffiliation	4 Weifang Medical University, Weifang, China 5 College of Medical Sciences, Bharatpur, Nepal 2 Chitwan Medical College, Bharatpur, Nepal 3 Nepalese Army Institute of Health Sciences, Kathmandu, Nepal 1 Department of Psychiatry and Mental Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal 6 Koshi Hospital, Biratnagar, Nepal Xiamen University - Malaysia Campus: Xiamen University - Malaysia, MALAYSIA
AuthorAffiliation_xml	– name: 3 Nepalese Army Institute of Health Sciences, Kathmandu, Nepal – name: 2 Chitwan Medical College, Bharatpur, Nepal – name: 4 Weifang Medical University, Weifang, China – name: 5 College of Medical Sciences, Bharatpur, Nepal – name: 6 Koshi Hospital, Biratnagar, Nepal – name: 1 Department of Psychiatry and Mental Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal – name: Xiamen University - Malaysia Campus: Xiamen University - Malaysia, MALAYSIA
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/36745620$$D View this record in MEDLINE/PubMed
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Title	Protocol for the systematic review and meta-analysis of factors associated with non-adherence to antidepressants in depressive disorders in those more than 18 years of age
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