The immortalizing and transforming ability of two common human papillomavirus 16 E6 variants with different prevalences in cervical cancer

Persistent infection with high-risk human papillomaviruses (HPVs), especially type 16 has been undeniably linked to cervical cancer. The Asian-American (AA) variant of HPV16 is more common in the Americas than the prototype in cervical cancer. The different prevalence is based on three amino acid ch...

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Bibliographic Details
Published in:	Oncogene Vol. 29; no. 23; pp. 3435 - 3445
Main Authors:	Richard, C, Lanner, C, Naryzhny, S N, Sherman, L, Lee, H, Lambert, P F, Zehbe, I
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10-06-2010 Nature Publishing Group
Subjects:	631/45/612/1243 692/699/67/1517/1371 692/699/67/1858 Amino acid sequence Analysis Anoikis Apoptosis Biological and medical sciences Cell Biology Cell culture Cell Differentiation Cell Line, Tumor Cell physiology Cell Proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cell Transformation, Neoplastic Cellular biology Cervical cancer Cervix Cytokeratin Development and progression DNA Damage E6 protein Enzyme Activation Female Female genital diseases Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects Genotype & phenotype Gynecology. Andrology. Obstetrics Human Genetics Human papillomavirus Human papillomavirus 16 Humans Identification and classification Immortalization Internal Medicine Keratinocytes Keratinocytes - metabolism Medical sciences Medicine Medicine & Public Health Molecular and cellular biology Oncogene Proteins, Viral - genetics Oncology original-article p53 Protein Papillomaviridae Papillomavirus E7 Proteins - genetics Papillomaviruses Proteomics Repressor Proteins - genetics Telomerase Telomerase - metabolism Tumor Suppressor Protein p53 - physiology Tumors Uterine Cervical Neoplasms - virology transformation immortalization cervical cancer human primary foreskin keratinocytes human papillomavirus Human Prevalence Papovaviridae Malignant tumor Carcinogenesis Female genital diseases Papillomavirus Virus Variant Human papillomavirus 16 Human papillomavirus Keratinocyte Uterine cervix diseases Cervical cancer Cancer
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