Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice

The intestinal mucus layer is a physical barrier separating the tremendous number of gut bacteria from the host epithelium. Defects in the mucus layer have been linked to metabolic diseases, but previous studies predominantly investigated mucus function during high-caloric/low-fiber dietary interven...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 295; no. 46; pp. 15712 - 15726
Main Authors:	Schroeder, Bjoern O., Birchenough, George M.H., Pradhan, Meenakshi, Nyström, Elisabeth E.L., Henricsson, Marcus, Hansson, Gunnar C., Bäckhed, Fredrik
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 13-11-2020 American Society for Biochemistry and Molecular Biology
Subjects:	Animals barrier dysfunction Blood Glucose - analysis Blood glucose level Colon - metabolism Colon - microbiology Colon - pathology Defects Dietary fibers Female Gastrointestinal Microbiome Glucose Glucose - metabolism Gut microbiota host defense intestinal epithelium Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Mammals Metabolic disease Metabolism Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Obese Microbiology Microbiology in the medical area microbiome Mikrobiologi inom det medicinska området Mucosal barriers mucosal immunology mucus Non-obese diabetics Nutrition obesity Obesity - genetics Obesity - pathology Phenotype Physical barriers Separate effects mucosal immunology host defense intestinal epithelium metabolism metabolic disease barrier dysfunction microbiome gut microbiota obesity mucus
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