Fomepizole for the Treatment of Ethylene Glycol Poisoning

Fomepizole for the Treatment of Ethylene Glycol Poisoning

Ethylene glycol poisoning may cause severe morbidity and death. 1 Though not toxic itself, ethylene glycol is converted by alcohol dehydrogenase to active metabolites 1 , 2 (Figure 1) that cause metabolic acidosis, renal failure, hypocalcemia, oxaluria, damage to the central nervous system and crani...

Full description

Saved in:
Bibliographic Details
Published in:The New England journal of medicine Vol. 340; no. 11; pp. 832 - 838
Main Authors: Brent, Jeffrey, McMartin, Kenneth, Phillips, Scott, Burkhart, Keith K, Donovan, J. Ward, Wells, Melanie, Kulig, Ken
Format: Journal Article
Language:English
Published: Boston, MA Massachusetts Medical Society 18-03-1999
Subjects:
Biological and medical sciences
Consent
Ethanol
Hemodialysis
Intensive care medicine. Antipoison centers
Medical sciences
Plasma
Poisoning
Toxicology
Human
Ethylene glycol
Chemotherapy
Treatment
Poisoning
Antidote
Fomepizole
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ethylene glycol poisoning may cause severe morbidity and death. 1 Though not toxic itself, ethylene glycol is converted by alcohol dehydrogenase to active metabolites 1 , 2 (Figure 1) that cause metabolic acidosis, renal failure, hypocalcemia, oxaluria, damage to the central nervous system and cranial nerves, and cardiovascular instability. 3 Standard treatments for ethylene glycol poisoning are hemodialysis and inhibition of alcohol dehydrogenase, 1 , 4 the latter by the intravenous or oral administration of high (intoxicating) doses of ethanol. The accepted target plasma ethanol concentration is 100 to 125 mg per deciliter (21.7 to 27.1 mmol per liter). 1 Since patients are treated with large doses . . .
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199903183401102