Cortical branched actin determines cell cycle progression

The actin cytoskeleton generates and senses forces. Here we report that branched actin networks from the cell cortex depend on ARPC1B-containing Arp2/3 complexes and that they are specifically monitored by type I coronins to control cell cycle progression in mammary epithelial cells. Cortical ARPC1B...

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Bibliographic Details
Published in:	Cell research Vol. 29; no. 6; pp. 432 - 445
Main Authors:	Molinie, Nicolas, Rubtsova, Svetlana N., Fokin, Artem, Visweshwaran, Sai P., Rocques, Nathalie, Polesskaya, Anna, Schnitzler, Anne, Vacher, Sophie, Denisov, Evgeny V., Tashireva, Lubov A., Perelmuter, Vladimir M., Cherdyntseva, Nadezhda V., Bièche, Ivan, Gautreau, Alexis M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-06-2019 Nature Publishing Group
Subjects:	13 13/1 13/89 13/95 14/63 631/67/1347 631/80/128/1276 631/80/84/1756 Actin Actins - metabolism Adult Aged Aged, 80 and over Biomedical and Life Sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cell Biology Cell Cycle Cell Line, Tumor Cell migration Cell Movement Cellular Biology Chemotherapy, Adjuvant Cohort Studies Cortex Cytoskeleton Dependence Diagnostic systems Epithelial cells Female G1 phase Growth factors Humans Life Sciences Mammary gland Mechanotransduction Metastases Middle Aged Rac1 protein Rigidity RNA, Messenger - genetics Subcellular Processes Tumors
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