Drug-Loaded Silver Nanoparticles-A Tool for Delivery of a Mebeverine Precursor in Inflammatory Bowel Diseases Treatment

• Published in: Biomedicines Vol. 11; no. 6; p. 1593
• Main Authors: Todorova, Mina, Milusheva, Miglena, Kaynarova, Lidia, Georgieva, Deyana, Delchev, Vassil, Simeonova, Stanislava, Pilicheva, Bissera, Nikolova, Stoyanka
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30-05-2023; MDPI
• Subjects: Chromatography; Colon; Drug delivery; Drug delivery systems; Drugs; Galactose; Gastrointestinal system; Gastrointestinal tract; green method; Inflammatory bowel disease; Inflammatory bowel diseases; Intestine; mebeverine precursor; Medical research; Medicine, Experimental; Nanoparticles; Pharmaceutical industry; Political aspects; Reagents; Silver; silver nanoparticles; Size distribution; Surface charge; Vehicles; Zeta potential; Bulgaria; Germany; galactose; inflammatory bowel diseases; silver nanoparticles; mebeverine precursor; green method
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines11061593

Chronic, multifactorial illnesses of the gastrointestinal tract include inflammatory bowel diseases. One of the greatest methods for regulated medicine administration in a particular region of inflammation is the nanoparticle system. Silver nanoparticles (Ag NPs) have been utilized as drug delivery systems in the pharmaceutical industry. The goal of the current study is to synthesize drug-loaded Ag NPs using a previously described 3-methyl-1-phenylbutan-2-amine, as a mebeverine precursor (MP). Methods: A green, galactose-assisted method for the rapid synthesis and stabilization of Ag NPs as a drug-delivery system is presented. Galactose was used as a reducing and capping agent forming a thin layer encasing the nanoparticles. Results: The structure, size distribution, zeta potential, surface charge, and the role of the capping agent of drug-loaded Ag NPs were discussed. The drug release of the MP-loaded Ag NPs was also investigated. The Ag NPs indicated a very good drug release between 80 and 85%. Based on the preliminary results, Ag NPs might be a promising medication delivery system for MP and a useful treatment option for inflammatory bowel disease. Therefore, future research into the potential medical applications of the produced Ag NPs is necessary.