Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: implications for bone repair during inflammation

Summary Objective The effects of inflammation on bone development from mesenchymal stem cells (MSC) are unclear due to the difficulty in isolating MSC. The aim of this study was to develop a MSC isolation method and to determine the in vitro effects of interleukin-1β (IL-1β) and tumor necrosis facto...

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Bibliographic Details
Published in:	Osteoarthritis and cartilage Vol. 17; no. 6; pp. 735 - 742
Main Authors:	Lacey, D.C, Simmons, P.J, Graves, S.E, Hamilton, J.A
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-06-2009
Subjects:	Animals Cell Differentiation - drug effects Cells, Cultured IL-1 Interleukin-1beta - genetics Interleukin-1beta - metabolism Mesenchymal stem cells Mesenchymal Stromal Cells - drug effects Mesenchymal Stromal Cells - metabolism Mice Osteoblasts and differentiation Osteogenesis - drug effects Osteogenesis - genetics Osteonectin - drug effects Osteonectin - genetics Osteopontin - drug effects Osteopontin - genetics Rheumatology TNF Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - metabolism IL-1 TNF Mesenchymal stem cells Osteoblasts and differentiation
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