Dysfunction in gap junction intercellular communication induces aberrant behavior of the inner cell mass and frequent collapses of expanded blastocysts in mouse embryos

Purpose We investigated the role of gap junctions (GJs) in embryological differentiation, and observed the morphological behavior of the inner cell mass (ICM) by time-lapse movie observation (TLM) with gap junction inhibitors (GJis). Methods ICR mouse embryos were exposed to two types of GJis in CZB...

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Bibliographic Details
Published in:	Journal of assisted reproduction and genetics Vol. 32; no. 6; pp. 969 - 976
Main Authors:	Togashi, Kazue, Kumagai, Jin, Sato, Emiko, Shirasawa, Hiromitsu, Shimoda, Yuki, Makino, Kenichi, Sato, Wataru, Kumazawa, Yukiyo, Omori, Yasufumi, Terada, Yukihiro
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-06-2015 Springer Nature B.V
Subjects:	Animals Blastocyst Inner Cell Mass - drug effects Blastocyst Inner Cell Mass - metabolism Blastocyst Inner Cell Mass - ultrastructure Cell Communication - drug effects Cell Communication - physiology Cell Differentiation - drug effects Communication Cytoplasm - ultrastructure Embryo Biology Embryo, Mammalian - cytology Embryo, Mammalian - drug effects Embryo, Mammalian - metabolism Embryonic Development - drug effects Embryos Female Females Gap Junctions - drug effects Gap Junctions - physiology Gap Junctions - ultrastructure Gynecology Heptanol - pharmacology Human Genetics Medicine Medicine & Public Health Mice Mice, Inbred ICR Morphology Oleic Acids - pharmacology Proteins Reproductive Medicine Signal transduction Time-Lapse Imaging United States > US Japan Delayed blastocyst formation Gap junction inhibitor Time-lapse movie observation Blastocoel collapse ICM division
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