Emergence of New Delhi metallo-beta-lactamase 1 and other carbapenemase-producing Acinetobacter calcoaceticus-baumannii complex among patients in hospitals in Ha Noi, Viet Nam

• Published in: European journal of clinical microbiology & infectious diseases Vol. 36; no. 2; pp. 219 - 225
• Main Authors: Tran, D. N., Tran, H. H., Matsui, M., Suzuki, M., Suzuki, S., Shibayama, K., Pham, T. D., Van Phuong, T. T., Dang, D. A., Trinh, H. S., Loan, C. T., Nga, L. T. V., van Doorn, H. R., Wertheim, H. F. L.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-02-2017; Springer Nature B.V
• Subjects: Acinetobacter; Acinetobacter baumannii; Acinetobacter baumannii - classification; Acinetobacter baumannii - enzymology; Acinetobacter baumannii - genetics; Acinetobacter baumannii - isolation & purification; Acinetobacter calcoaceticus - classification; Acinetobacter calcoaceticus - enzymology; Acinetobacter calcoaceticus - genetics; Acinetobacter calcoaceticus - isolation & purification; Acinetobacter Infections - epidemiology; Acinetobacter Infections - microbiology; Adolescent; Adult; Aged; Antibiotics; Antimicrobial agents; Bacterial Proteins - secretion; beta-Lactam Resistance; beta-Lactamases - secretion; Biomedical and Life Sciences; Biomedicine; Carbapenems - pharmacology; Child; Child, Preschool; Drug resistance; Epidemiology; Female; Genes; Genotype; Hospitals; Humans; Infant; Infectious diseases; Internal Medicine; Male; Medical Microbiology; Microbial Sensitivity Tests; Middle Aged; Molecular Typing; Nosocomial infections; Original; Original Article; Pathogens; Plasmids; Plasmids - analysis; Prospective Studies; Vietnam - epidemiology; Young Adult; East Asia; Vietnam; Carbapenem Resistance; Meropenem; Colistin; Acinetobacter Baumannii; Imipenem
• ISSN: 0934-9723; 1435-4373
• DOI: 10.1007/s10096-016-2784-8

Acinetobacter baumannii
is an important cause of multidrug-resistant hospital acquired infections in the world. Here, we investigate the presence of NDM-1 and other carbapenemases among carbapenem-resistant
A. baumannii
isolated between August 2010 and December 2014 from three large hospitals in Hanoi, Vietnam. We identified 23/582 isolates (4 %) (11 from hospital A, five from hospital B, and seven from hospital C) that were NDM-1 positive, and among them 18 carried additional carbapenemase genes, including seven isolates carrying NDM-1, IMP-1, and OXA-58 with high MICs for carbapenems. Genotyping indicated that NDM-1 carrying
A. baumannii
have expanded clonally in these hospitals. Five new STs (ST1135, ST1136, ST1137, ST1138, and ST1139) were identified. One isolate carried NDM-1 on a plasmid belonging to the N-repA replicon type; no NDM-1-positive plasmids were identified in the other isolates. We have shown the extent of the carbapenem resistance and the local clonal spread of
A. baumannii
carrying NDM-1 in these hospitals; coexistence of NDM-1 and IMP-1 is reported for the first time from Vietnam here, and this will further seriously limit future therapeutic options.