Cyclosporin A elicits dose-dependent biphasic effects on osteoblast differentiation and bone formation

Abstract Cyclosporin A (CsA) is thought to prevent immune reactions after organ transplantation by inhibiting calcineurin (Cn) and its substrate, the Nuclear Factor of Activated T Cells (NFAT). A dichotomy exists in describing the effects of CsA on bone formation. The concept that the suppression of...

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Bibliographic Details
Published in:	Bone (New York, N.Y.) Vol. 40; no. 6; pp. 1502 - 1516
Main Authors:	Yeo, Hyeonju, Beck, Lauren H, McDonald, Jay M, Zayzafoon, Majd
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-06-2007 Elsevier Science
Subjects:	Alkaline Phosphatase - metabolism Animals AP-1 Biological and medical sciences Bone Calcineurin Cell Differentiation - drug effects Cells, Cultured Cyclosporin Cyclosporine - pharmacology Diseases of the osteoarticular system Dose-Response Relationship, Drug Fra-2 Fundamental and applied biological sciences. Psychology Gene Silencing Genes, Reporter Immunosuppressive Agents - pharmacology Luciferases - analysis Luciferases - metabolism Male Medical sciences Mice Mice, Inbred BALB C NFAT NFATC Transcription Factors - metabolism Orthopedics Osteoblasts Osteoblasts - drug effects Osteoblasts - physiology Osteogenesis - drug effects Osteoporosis. Osteomalacia. Paget disease RNA, Small Interfering - metabolism Transfection Transplantation Vertebrates: anatomy and physiology, studies on body, several organs or systems Cyclosporin Fra-2 Calcineurin Transplantation Bone Osteoblasts AP-1 NFAT Diseases of the osteoarticular system Osteoporosis Treatment Surgery Morphology Osteoblast Graft Ciclosporin Immunosuppressive agent Dose
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