Implication of respiratory syncytial virus (RSV) F transgene sequence heterogeneity observed in Phase 1 evaluation of MEDI-534, a live attenuated parainfluenza type 3 vectored RSV vaccine

Highlights • The live RSV vaccine virus was primarily detected in young children post dose 1. • About half of the shed vaccine viruses (13/24) contained sequence changes. • These sequence changes may result in lower RSVF protein expression. • These changes may have been selected during replication i...

Full description

Saved in:

Bibliographic Details
Published in:	Vaccine Vol. 31; no. 26; pp. 2822 - 2827
Main Authors:	Yang, Chin-Fen, Wang, C. Kathy, Malkin, Elissa, Schickli, Jeanne H, Shambaugh, Cindy, Zuo, Fengrong, Galinski, Mark S, Dubovsky, Filip, Tang, Roderick S
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 10-06-2013 Elsevier Elsevier Limited
Subjects:	Age Allergy and Immunology Animals Antibodies, Viral - blood Applied microbiology Biological and medical sciences Bovine parainfluenza virus 3 Cattle children Cohort Studies Deoxyribonucleic acid DNA fluorescent antibody technique Fundamental and applied biological sciences. Psychology Glycoproteins Heterogeneity Humans Immunization Immunogenicity Infant Microbiology nose nucleotides open reading frames Parainfluenza virus Parainfluenza Virus 3, Bovine - genetics Parainfluenza Virus 3, Bovine - immunology Parainfluenza Virus 3, Human - genetics Parainfluenza Virus 3, Human - immunology Polymerase chain reaction Proteins Respiratory syncytial virus Respiratory syncytial virus (RSV) Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Virus Infections - prevention & control Respiratory Syncytial Viruses - genetics Respiratory Syncytial Viruses - immunology RSV F expression Sequence Analysis, DNA stop codon Subpopulations Transgenes Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Viral Vaccines - genetics Viral Vaccines - immunology Virus Shedding Virus variants viruses Virus variants Respiratory syncytial virus (RSV) RSV F expression Immunogenicity Human Retroviridae Vaccine Virus Human syncytial virus Spumavirus Phase I trial Attenuated strain Child Vector
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!