Novel Role for Integrin-Linked Kinase in Modulation of Coxsackievirus B3 Replication and Virus-Induced Cardiomyocyte Injury

Viral myocarditis is a major cause of sudden cardiac death in children and young adults. Among viruses, coxsackievirus B3 (CVB3) is the most common agent for myocarditis. Recently, more consideration has been given to the role of signaling pathways in pathogenesis of enteroviral myocarditis, providi...

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Bibliographic Details
Published in:	Circulation research Vol. 99; no. 4; pp. 354 - 361
Main Authors:	Esfandiarei, Mitra, Suarez, Agripina, Amaral, Ansel, Si, Xiaoning, Rahmani, Maziar, Dedhar, Shoukat, McManus, Bruce M
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD American Heart Association, Inc 18-08-2006 Lippincott
Subjects:	Animals Biological and medical sciences Cardiology. Vascular system Cell Line Coxsackievirus B3 Enterovirus - genetics Enterovirus - physiology Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Heart Heart - virology HeLa Cells Humans In Situ Hybridization Medical sciences Mice Muscle Cells - enzymology Muscle Cells - virology Myocarditis - virology Myocarditis. Cardiomyopathies Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism RNA, Viral - genetics Vertebrates: cardiovascular system Virus Replication PKB/Akt Enzyme Picornaviridae Transferases Cardiovascular disease Enterovirus Myocardial disease Virus Myocarditis Vertebrata Integrin Mammalia Kinase Cell death Heart disease Coxsackievirus B3 Replication Circulatory system Lesion CVB3 integrin-linked kinase viral myocarditis Heart cell
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