Targeting heat shock protein 70 using gold nanorods enhances cancer cell apoptosis in low dose plasmonic photothermal therapy

Abstract Plasmonic photothermal therapy (PPTT) is a promising cancer treatment where plasmonic nanoparticles are used to convert near infrared light to localized heat to cause cell death, mainly via apoptosis and necrosis. Modulating PPTT to induce cell apoptosis is more favorable than necrosis. Her...

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Bibliographic Details
Published in:	Biomaterials Vol. 102; pp. 1 - 8
Main Authors:	Ali, Moustafa R.K, Ali, Hala R, Rankin, Carl R, El-Sayed, Mostafa A
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01-09-2016
Subjects:	Advanced Basic Science Apoptosis Biotechnology Cancer Cell Line, Tumor Cellular Dentistry Gold Gold - chemistry Gold - therapeutic use Gold nanorods (AuNRs) Heat shock protein 70 (HSP70) HSP70 Heat-Shock Proteins - metabolism Humans Hyperthermia, Induced - methods MCF-7 Cells Nanorods Nanotubes - chemistry Nanotubes - ultrastructure Neoplasms - metabolism Neoplasms - therapy Phototherapy - methods Plasmonic photothermal therapy (PPTT) Plasmonics Protein refolding Quercetin (QE) Therapy Plasmonic photothermal therapy (PPTT) Quercetin (QE) Heat shock protein 70 (HSP70) Protein refolding Gold nanorods (AuNRs)
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