Double-Stranded RNA Induces Pancreatic β-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways

Double-Stranded RNA Induces Pancreatic β-Cell Apoptosis by Activation of the Toll-Like Receptor 3 and Interferon Regulatory Factor 3 Pathways Zeynep Dogusan 1 , Mónica García 1 , Daisy Flamez 1 , Lena Alexopoulou 2 , Michel Goldman 3 , Conny Gysemans 4 , Chantal Mathieu 4 , Claude Libert 5 , Decio L...

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Bibliographic Details
Published in:	Diabetes (New York, N.Y.) Vol. 57; no. 5; pp. 1236 - 1245
Main Authors:	DOGUSAN, Zeynep, GARCIA, Monica, FLAMEZ, Daisy, ALEXOPONLOU, Lena, GOLDMAN, Michel, GYSEMANS, Conny, MATHIEN, Chantal, LIBERT, Claude, EIZIRIK, Decio L, RASSCHAERT, Joanne
Format:	Journal Article
Language:	English
Published:	Alexandria, VA American Diabetes Association 01-05-2008
Subjects:	Animals Apoptosis Biological and medical sciences Cell Survival Cells, Cultured Diabetes. Impaired glucose tolerance DNA binding proteins Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Genetic aspects Health aspects Immunology Influence Insulin-Secreting Cells - cytology Insulin-Secreting Cells - physiology Interferon Interferon Regulatory Factor-3 - physiology Interferon-beta - biosynthesis Life Sciences Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Pancreatic beta cells Poly I-C - pharmacology Properties Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction RNA RNA, Double-Stranded - genetics Toll-Like Receptor 3 - deficiency Toll-Like Receptor 3 - genetics Toll-Like Receptor 3 - physiology Type 1 diabetes Belgium Endocrinopathy RNA Cell death Diabetes mellitus Cytokine Langerhans islet Interferon β Cell Endocrine pancreas Apoptosis Biological receptor
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