Increasing resolution in stress neurobiology: from single cells to complex group behaviors

• Published in: Stress (Amsterdam, Netherlands) Vol. 26; no. 1; p. 2186141
• Main Authors: Miranda, Lucas, Bordes, Joeri, Gasperoni, Serena, Lopez, Juan Pablo
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 2023; Taylor & Francis Group
• Subjects: animal models of stress; Animals; Anxiety Disorders; complex behaviours; computational science; Humans; Mass Behavior; Medicin och hälsovetenskap; molecular neurobiology; Neurobiology; single cells; Stress neurobiology; Stress, Psychological; molecular neurobiology; Stress neurobiology; computational science; single cells; complex behaviours; animal models of stress
• ISSN: 1025-3890; 1607-8888; 1607-8888
• DOI: 10.1080/10253890.2023.2186141

Stress can have severe psychological and physiological consequences. Thus, inappropriate regulation of the stress response is linked to the etiology of mood and anxiety disorders. The generation and implementation of preclinical animal models represent valuable tools to explore and characterize the mechanisms underlying the pathophysiology of stress-related psychiatric disorders and the development of novel pharmacological strategies. In this commentary, we discuss the strengths and limitations of state-of-the-art molecular and computational advances employed in stress neurobiology research, with a focus on the ever-increasing spatiotemporal resolution in cell biology and behavioral science. Finally, we share our perspective on future directions in the fields of preclinical and human stress research.