Sox4 mediates Tbx3 transcriptional regulation of the gap junction protein Cx43

Tbx3, a T-box transcription factor, regulates key steps in development of the heart and other organ systems. Here, we identify Sox4 as an interacting partner of Tbx3. Pull-down and nuclear retention assays verify this interaction and in situ hybridization reveals Tbx3 and Sox4 to co-localize extensi...

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Bibliographic Details
Published in:	Cellular and molecular life sciences : CMLS Vol. 68; no. 23; pp. 3949 - 3961
Main Authors:	Boogerd, C. J. J., Wong, L. Y. E., van den Boogaard, M., Bakker, M. L., Tessadori, F., Bakkers, J., ‘t Hoen, P. A. C., Moorman, A. F., Christoffels, V. M., Barnett, P.
Format:	Journal Article
Language:	English
Published:	Basel SP Birkhäuser Verlag Basel 01-12-2011 Springer Nature B.V
Subjects:	Amino Acid Sequence Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Chlorocebus aethiops Connexin 43 - genetics COS Cells Danio rerio Embryos Freshwater Gene Expression Regulation Humans Hybridization Life Sciences Male Mice Molecular Sequence Data Proteins Research Article SOXC Transcription Factors - chemistry SOXC Transcription Factors - metabolism T-Box Domain Proteins - metabolism Transcription, Genetic Zebrafish Gja1 Enhancer Heart development Interaction Tbx3 Sox4
Online Access:	Get full text
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