Pomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate
This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing (pomegranate) peel extract (PPE), sodium-trimetaphosphate, and low concentrations of fluoride. PPE was characterized using high-performance liquid chromatography (ellagic acid and punicalagin)....
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| Published in: | Antibiotics (Basel) Vol. 11; no. 11; p. 1477 |
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| Main Authors: | , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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| Abstract | This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing
(pomegranate) peel extract (PPE), sodium-trimetaphosphate, and low concentrations of fluoride. PPE was characterized using high-performance liquid chromatography (ellagic acid and punicalagin). Total phenolics were quantified among formulations, and their stability was analyzed for 28 days. The formulation effects were evaluated as follows: (1) inorganic component concentration and reduced demineralization on bovine enamel blocks subjected to pH cycling; (2) anti-biofilm effect on dual-biofilms of
ATCC 25175 and
ATCC 10231 treated for 1 and 10 min, respectively; and (3) cytotoxicity and production of inflammatory mediators (interleukin-6 and tumor necrosis factor-alpha). The formulation containing 3% PPE, 0.3% sodium-trimetaphosphate, and 225 ppm of fluoride resulted in a 34.5% surface hardness loss; a 13% (treated for 1 min) and 36% (treated for 10 min) biofilm reduction in
; a 26% (1 min) and 36% (10 min) biofilm reduction in
; absence of cytotoxicity; and anti-inflammatory activity confirmed by decreased interleukin-6 production in mouse macrophages. Thus, our results provide a promising prospect for the development of an alcohol-free commercial dental product with the health benefits of
that have been recognized for a millennium. |
|---|---|
| AbstractList | This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing Punica granatum (pomegranate) peel extract (PPE), sodium-trimetaphosphate, and low concentrations of fluoride. PPE was characterized using high-performance liquid chromatography (ellagic acid and punicalagin). Total phenolics were quantified among formulations, and their stability was analyzed for 28 days. The formulation effects were evaluated as follows: (1) inorganic component concentration and reduced demineralization on bovine enamel blocks subjected to pH cycling; (2) anti-biofilm effect on dual-biofilms of Streptococcus mutans ATCC 25175 and Candida albicans ATCC 10231 treated for 1 and 10 min, respectively; and (3) cytotoxicity and production of inflammatory mediators (interleukin-6 and tumor necrosis factor-alpha). The formulation containing 3% PPE, 0.3% sodium-trimetaphosphate, and 225 ppm of fluoride resulted in a 34.5% surface hardness loss; a 13% (treated for 1 min) and 36% (treated for 10 min) biofilm reduction in S. mutans; a 26% (1 min) and 36% (10 min) biofilm reduction in C. albicans; absence of cytotoxicity; and anti-inflammatory activity confirmed by decreased interleukin-6 production in mouse macrophages. Thus, our results provide a promising prospect for the development of an alcohol-free commercial dental product with the health benefits of P. granatum that have been recognized for a millennium.This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing Punica granatum (pomegranate) peel extract (PPE), sodium-trimetaphosphate, and low concentrations of fluoride. PPE was characterized using high-performance liquid chromatography (ellagic acid and punicalagin). Total phenolics were quantified among formulations, and their stability was analyzed for 28 days. The formulation effects were evaluated as follows: (1) inorganic component concentration and reduced demineralization on bovine enamel blocks subjected to pH cycling; (2) anti-biofilm effect on dual-biofilms of Streptococcus mutans ATCC 25175 and Candida albicans ATCC 10231 treated for 1 and 10 min, respectively; and (3) cytotoxicity and production of inflammatory mediators (interleukin-6 and tumor necrosis factor-alpha). The formulation containing 3% PPE, 0.3% sodium-trimetaphosphate, and 225 ppm of fluoride resulted in a 34.5% surface hardness loss; a 13% (treated for 1 min) and 36% (treated for 10 min) biofilm reduction in S. mutans; a 26% (1 min) and 36% (10 min) biofilm reduction in C. albicans; absence of cytotoxicity; and anti-inflammatory activity confirmed by decreased interleukin-6 production in mouse macrophages. Thus, our results provide a promising prospect for the development of an alcohol-free commercial dental product with the health benefits of P. granatum that have been recognized for a millennium. This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing Punica granatum (pomegranate) peel extract (PPE), sodium-trimetaphosphate, and low concentrations of fluoride. PPE was characterized using high-performance liquid chromatography (ellagic acid and punicalagin). Total phenolics were quantified among formulations, and their stability was analyzed for 28 days. The formulation effects were evaluated as follows: (1) inorganic component concentration and reduced demineralization on bovine enamel blocks subjected to pH cycling; (2) anti-biofilm effect on dual-biofilms of Streptococcus mutans ATCC 25175 and Candida albicans ATCC 10231 treated for 1 and 10 min, respectively; and (3) cytotoxicity and production of inflammatory mediators (interleukin-6 and tumor necrosis factor-alpha). The formulation containing 3% PPE, 0.3% sodium-trimetaphosphate, and 225 ppm of fluoride resulted in a 34.5% surface hardness loss; a 13% (treated for 1 min) and 36% (treated for 10 min) biofilm reduction in S. mutans ; a 26% (1 min) and 36% (10 min) biofilm reduction in C. albicans ; absence of cytotoxicity; and anti-inflammatory activity confirmed by decreased interleukin-6 production in mouse macrophages. Thus, our results provide a promising prospect for the development of an alcohol-free commercial dental product with the health benefits of P. granatum that have been recognized for a millennium. This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing (pomegranate) peel extract (PPE), sodium-trimetaphosphate, and low concentrations of fluoride. PPE was characterized using high-performance liquid chromatography (ellagic acid and punicalagin). Total phenolics were quantified among formulations, and their stability was analyzed for 28 days. The formulation effects were evaluated as follows: (1) inorganic component concentration and reduced demineralization on bovine enamel blocks subjected to pH cycling; (2) anti-biofilm effect on dual-biofilms of ATCC 25175 and ATCC 10231 treated for 1 and 10 min, respectively; and (3) cytotoxicity and production of inflammatory mediators (interleukin-6 and tumor necrosis factor-alpha). The formulation containing 3% PPE, 0.3% sodium-trimetaphosphate, and 225 ppm of fluoride resulted in a 34.5% surface hardness loss; a 13% (treated for 1 min) and 36% (treated for 10 min) biofilm reduction in ; a 26% (1 min) and 36% (10 min) biofilm reduction in ; absence of cytotoxicity; and anti-inflammatory activity confirmed by decreased interleukin-6 production in mouse macrophages. Thus, our results provide a promising prospect for the development of an alcohol-free commercial dental product with the health benefits of that have been recognized for a millennium. This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing Punica granatum (pomegranate) peel extract (PPE), sodium-trimetaphosphate, and low concentrations of fluoride. PPE was characterized using high-performance liquid chromatography (ellagic acid and punicalagin). Total phenolics were quantified among formulations, and their stability was analyzed for 28 days. The formulation effects were evaluated as follows: (1) inorganic component concentration and reduced demineralization on bovine enamel blocks subjected to pH cycling; (2) anti-biofilm effect on dual-biofilms of Streptococcus mutans ATCC 25175 and Candida albicans ATCC 10231 treated for 1 and 10 min, respectively; and (3) cytotoxicity and production of inflammatory mediators (interleukin-6 and tumor necrosis factor-alpha). The formulation containing 3% PPE, 0.3% sodium-trimetaphosphate, and 225 ppm of fluoride resulted in a 34.5% surface hardness loss; a 13% (treated for 1 min) and 36% (treated for 10 min) biofilm reduction in S. mutans; a 26% (1 min) and 36% (10 min) biofilm reduction in C. albicans; absence of cytotoxicity; and anti-inflammatory activity confirmed by decreased interleukin-6 production in mouse macrophages. Thus, our results provide a promising prospect for the development of an alcohol-free commercial dental product with the health benefits of P. granatum that have been recognized for a millennium. |
| Audience | Academic |
| Author | Barbosa, Debora Barros Berretta, Andresa Aparecida Hori, Juliana Issa Emerenciano, Nayara Gonçalves Vieira, Ana Paula Miranda Buszinski, Andrei Felipe Moreira Lima, Mikhael Haruo Fernandes de Fernandes, Gabriela Lopes Lima, Jessica Aparecida de Reis, Thaila Fernanda Dos Silva, Sónia Carina Morais da Delbem, Alberto Carlos Botazzo Danelon, Marcelle |
| AuthorAffiliation | 2 School of Dentistry, University of Ribeirão Preto—UNAERP, Ribeirão Preto 14096-039, São Paulo, Brazil 1 Graduate Program of Dental Science, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil 6 Department of Dental Materials and Prosthodontics, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil 7 National Institute for Agrarian and Veterinary Research (INIAV), Vairão, 4485-655 Vila do Conde, Portugal 4 Apis Flora Industrial and Comercial Ltd. Ribeirão Preto 14020-670, São Paulo, Brazil 3 Department of Restorative Dentistry, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil 5 Department of Biochemistry and Immunology, University of São Paulo Ribeirão Preto, Ribeirão Preto 14049-900, São Paulo, Brazil |
| AuthorAffiliation_xml | – name: 1 Graduate Program of Dental Science, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil – name: 3 Department of Restorative Dentistry, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil – name: 6 Department of Dental Materials and Prosthodontics, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil – name: 2 School of Dentistry, University of Ribeirão Preto—UNAERP, Ribeirão Preto 14096-039, São Paulo, Brazil – name: 5 Department of Biochemistry and Immunology, University of São Paulo Ribeirão Preto, Ribeirão Preto 14049-900, São Paulo, Brazil – name: 4 Apis Flora Industrial and Comercial Ltd. Ribeirão Preto 14020-670, São Paulo, Brazil – name: 7 National Institute for Agrarian and Veterinary Research (INIAV), Vairão, 4485-655 Vila do Conde, Portugal |
| Author_xml | – sequence: 1 givenname: Gabriela Lopes surname: Fernandes fullname: Fernandes, Gabriela Lopes organization: Graduate Program of Dental Science, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil – sequence: 2 givenname: Ana Paula Miranda surname: Vieira fullname: Vieira, Ana Paula Miranda organization: Graduate Program of Dental Science, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil – sequence: 3 givenname: Marcelle orcidid: 0000-0003-2091-649X surname: Danelon fullname: Danelon, Marcelle organization: Department of Restorative Dentistry, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil – sequence: 4 givenname: Nayara Gonçalves surname: Emerenciano fullname: Emerenciano, Nayara Gonçalves organization: Graduate Program of Dental Science, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil – sequence: 5 givenname: Andresa Aparecida surname: Berretta fullname: Berretta, Andresa Aparecida organization: Apis Flora Industrial and Comercial Ltd. Ribeirão Preto 14020-670, São Paulo, Brazil – sequence: 6 givenname: Andrei Felipe Moreira surname: Buszinski fullname: Buszinski, Andrei Felipe Moreira organization: Apis Flora Industrial and Comercial Ltd. Ribeirão Preto 14020-670, São Paulo, Brazil – sequence: 7 givenname: Juliana Issa orcidid: 0000-0002-5421-3728 surname: Hori fullname: Hori, Juliana Issa organization: Apis Flora Industrial and Comercial Ltd. Ribeirão Preto 14020-670, São Paulo, Brazil – sequence: 8 givenname: Mikhael Haruo Fernandes de surname: Lima fullname: Lima, Mikhael Haruo Fernandes de organization: Department of Biochemistry and Immunology, University of São Paulo Ribeirão Preto, Ribeirão Preto 14049-900, São Paulo, Brazil – sequence: 9 givenname: Thaila Fernanda Dos surname: Reis fullname: Reis, Thaila Fernanda Dos organization: Department of Dental Materials and Prosthodontics, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil – sequence: 10 givenname: Jessica Aparecida de surname: Lima fullname: Lima, Jessica Aparecida de organization: Apis Flora Industrial and Comercial Ltd. Ribeirão Preto 14020-670, São Paulo, Brazil – sequence: 11 givenname: Alberto Carlos Botazzo orcidid: 0000-0002-8159-4853 surname: Delbem fullname: Delbem, Alberto Carlos Botazzo organization: Department of Restorative Dentistry, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil – sequence: 12 givenname: Sónia Carina Morais da orcidid: 0000-0003-0000-7387 surname: Silva fullname: Silva, Sónia Carina Morais da organization: National Institute for Agrarian and Veterinary Research (INIAV), Vairão, 4485-655 Vila do Conde, Portugal – sequence: 13 givenname: Debora Barros orcidid: 0000-0002-3623-5093 surname: Barbosa fullname: Barbosa, Debora Barros organization: Department of Dental Materials and Prosthodontics, School of Dentistry, Araçatuba, São Paulo State University (UNESP), Araçatuba 16015-050, São Paulo, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36358132$$D View this record in MEDLINE/PubMed |
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| Snippet | This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing
(pomegranate) peel extract (PPE),... This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing Punica granatum (pomegranate) peel extract (PPE),... This study investigated the anti-caries and anti-inflammatory effects of mouthwash formulations containing Punica granatum (pomegranate) peel extract (PPE),... |
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| StartPage | 1477 |
| SubjectTerms | Acids Alcohol free anti-inflammatory Anti-inflammatory agents Anti-inflammatory drugs antimicrobial Biofilms Cytokines Cytotoxicity Demineralization Demineralizing Dental caries Dental enamel Dentifrices Disease Ellagic acid Enamel Fluoride Fluorides High performance liquid chromatography Inflammation Instrument industry Interleukin 6 Interleukins Liquid chromatography Low concentrations Macrophages Methyl salicylate Microorganisms Mouthwashes Oral hygiene products Phenols Plant extracts polyphosphates Punica granatum Sodium Stability analysis Surface hardness Toiletries industry Toxicity Tumor necrosis factor-TNF Tumor necrosis factor-α |
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| Title | Pomegranate Extract Potentiates the Anti-Demineralizing, Anti-Biofilm, and Anti-Inflammatory Actions of Non-Alcoholic Mouthwash When Associated with Sodium-Fluoride Trimetaphosphate |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/36358132 https://www.proquest.com/docview/2734597482 https://www.proquest.com/docview/2735892544 https://pubmed.ncbi.nlm.nih.gov/PMC9686636 https://doaj.org/article/1793bc6067fe48558a58514270677ea5 |
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