type 1 diabetes protective HLA DQB10602 allele is less frequent in gestational diabetes mellitus

• Published in: Diabetologia Vol. 52; no. 7; pp. 1339 - 1342
• Main Authors: Papadopoulou, A, Lynch, K. F, Shaat, N, Nilsson, A, Lernmark, B, Berntorp, K, Ivarsson, S.-A, Agardh, C.-D, Lernmark, Å
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01-07-2009; Springer-Verlag; Springer; Springer Nature B.V
• Subjects: Alleles; Antibodies; Antigens; Biological and medical sciences; Clinical Medicine; Country of birth; Diabetes Mellitus, Type 1 - epidemiology; Diabetes Mellitus, Type 1 - genetics; Diabetes, Gestational - epidemiology; Diabetes, Gestational - genetics; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinology and Diabetes; Endocrinopathies; Endokrinologi och diabetes; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Genetic Predisposition to Disease - epidemiology; Genotype; Gestational diabetes; HLA-DQ Antigens - genetics; HLA-DQ beta-Chains; Human Physiology; Humans; Insulin; Internal Medicine; Klinisk medicin; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Medicine; Medicine & Public Health; Membrane Glycoproteins - genetics; Metabolic Diseases; Mothers; Pregnancy; Proteins; Regression analysis; Risk Factors; Short Communication; Siblings; Sweden; Gestational diabetes mellitus; HLA; Endocrinopathy; Immunopathology; HLA-System; Allele; Type 1 diabetes; Autoimmune disease; Gestational diabetes
• ISSN: 0012-186X; 1432-0428; 1432-0428
• DOI: 10.1007/s00125-009-1351-6

Aims/hypothesis We tested whether gestational diabetes mellitus (GDM) is associated with HLA-DQ genotypes. Methods A total of 764 mothers with non-autoimmune (GAD65, insulinoma-associated protein 2 [IA-2] and insulin autoantibody-negative) GDM were ascertained between September 2000 and August 2004 in the population-based Diabetes Prediction in Skåne (DiPiS) study. HLA-DQB1 genotypes were determined in these mothers and in 1191 randomly selected non-diabetic control mothers also negative for islet autoantibodies. The data were analysed in relation to maternal age, country of birth, number of pregnancies/siblings and pregnancy weight gain. Results The frequency of type 1 diabetes high-risk HLA-DQ alleles (DQB1*0201, DQB1*0302) did not differ between GDM mothers and controls. In contrast, the low-risk DQB1*0602 allele was less prevalent (OR 0.64, 95% CI = 0.51-0.80, p = 0.0006) in GDM than in control mothers. The difference in DQB1*0602 frequency between GDM mothers and controls remained after multiple logistic regression analysis correcting for maternal age, country of birth, number of pregnancies/siblings and weight gain during pregnancy (OR 0.67, 95% CI 0.51-0.88, p = 0.009). Conclusions/interpretation The negative association between mothers who have non-autoimmune GDM and HLA-DQ*0602 suggest that this allele may protect not only from type 1 diabetes but also from GDM.