Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirus
The open reading frame 3 (ORF3) of the severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes a predicted 154-amino acid protein, which lacks similarities to any known protein, and is named 3b. In this study, it was shown that 3b protein was predominately localized to nucleus with E...
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| Published in: | Virus research Vol. 114; no. 1; pp. 70 - 79 |
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01-12-2005
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| Abstract | The open reading frame 3 (ORF3) of the severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes a predicted 154-amino acid protein, which lacks similarities to any known protein, and is named 3b. In this study, it was shown that 3b protein was predominately localized to nucleus with EGFP tag at its N- or C-terminus. The localization patterns were similar in different transfected cells. Immuno-fluorescence assay revealed that 3b protein was co-localized well with C23 in nucleolus. C23, B23 and fibrillarin all are important nucleolar proteins, which localize in the region of the nucleolus. Co-transfection of p3b-EGFP with pC23-DsRed, pB23-DsRed and pfibrillarin-DsRed further confirmed 3b's nucleolus localization. With construction of serial truncated mutants of 3b, a region (residues 134–154 aa) responsible for nucleolar localization was determinated in 3b protein. These results provide a new insight for further functional studies of SARS-CoV 3b protein. |
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| AbstractList | The open reading frame 3 (ORF3) of the severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes a predicted 154-amino acid protein, which lacks similarities to any known protein, and is named 3b. In this study, it was shown that 3b protein was predominately localized to nucleus with EGFP tag at its N- or C-terminus. The localization patterns were similar in different transfected cells. Immuno-fluorescence assay revealed that 3b protein was co-localized well with C23 in nucleolus. C23, B23 and fibrillarin all are important nucleolar proteins, which localize in the region of the nucleolus. Co-transfection of p3b-EGFP with pC23-DsRed, pB23-DsRed and pfibrillarin-DsRed further confirmed 3b's nucleolus localization. With construction of serial truncated mutants of 3b, a region (residues 134–154 aa) responsible for nucleolar localization was determinated in 3b protein. These results provide a new insight for further functional studies of SARS-CoV 3b protein. |
| Author | Yang, Zhen Zhao, Zhenhu Yao, Zhenyu Wu, Jie Cong, Yuwen Shan, Yajun Yuan, Xiaoling Chen, Jiapei Chen, Bo |
| Author_xml | – sequence: 1 givenname: Xiaoling surname: Yuan fullname: Yuan, Xiaoling – sequence: 2 givenname: Zhenyu surname: Yao fullname: Yao, Zhenyu – sequence: 3 givenname: Yajun surname: Shan fullname: Shan, Yajun – sequence: 4 givenname: Bo surname: Chen fullname: Chen, Bo – sequence: 5 givenname: Zhen surname: Yang fullname: Yang, Zhen – sequence: 6 givenname: Jie surname: Wu fullname: Wu, Jie – sequence: 7 givenname: Zhenhu surname: Zhao fullname: Zhao, Zhenhu – sequence: 8 givenname: Jiapei surname: Chen fullname: Chen, Jiapei – sequence: 9 givenname: Yuwen surname: Cong fullname: Cong, Yuwen email: congyw@nic.bmi.ac.cn |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16046244$$D View this record in MEDLINE/PubMed |
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| Keywords | PBS DMEM ORF NLS SARS-CoV SARS EGFP NoLS N ECL |
| Language | English |
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| SubjectTerms | Amino Acid Sequence Animals Cell Line Cell Nucleolus - metabolism Chlorocebus aethiops Chromosomal Proteins, Non-Histone - metabolism COS Cells Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Humans Nuclear Proteins - metabolism Nucleolin Nucleophosmin Phosphoproteins - metabolism Protein Sorting Signals RNA-Binding Proteins - metabolism SARS coronavirus Severe acute respiratory syndrome-related coronavirus - genetics Severe acute respiratory syndrome-related coronavirus - metabolism Severe acute respiratory syndrome-related coronavirus - pathogenicity Transfection Vero Cells Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism |
| Title | Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirus |
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