Inhibition effects of furfural on alcohol dehydrogenase, aldehyde dehydrogenase and pyruvate dehydrogenase

The kinetics of furfural inhibition of the enzymes alcohol dehydrogenase (ADH; EC 1.1.1.1), aldehyde dehydrogenase (AlDH; EC 1.2.1.5) and the pyruvate dehydrogenase (PDH) complex were studied in vitro. At a concentration of less than 2 mM furfural was found to decrease the activity of both PDH and A...

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Bibliographic Details
Published in:	Biochemical journal Vol. 363; no. Pt 3; pp. 769 - 776
Main Authors:	Modig, Tobias, Lidén, Gunnar, Taherzadeh, Mohammad J
Format:	Journal Article
Language:	English
Published:	England 01-05-2002
Subjects:	A1DH Acetaldehyde ADH Alcohol Dehydrogenase - antagonists & inhibitors Aldehyde Dehydrogenase - antagonists & inhibitors Binding Binding, Competitive Biochemistry and Molecular Biology Biokemi och molekylärbiologi Biologi Biological Sciences Chemical Competitive Furaldehyde - analogs & derivatives Furaldehyde - pharmacology HMF Kinetics Models, Chemical Natural Sciences Naturvetenskap PDH Pyruvate Dehydrogenase Complex - antagonists & inhibitors Pyruvate Dehydrogenase Complex - metabolism Pyruvic Acid - metabolism Saccharomyces cerevisiae - enzymology
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