Efficacy and Safety of Saxagliptin When Added to Metformin Therapy in Patients With Inadequately Controlled Type 2 Diabetes With Metformin Alone

OBJECTIVE: This 24-week trial assessed the efficacy and safety of saxagliptin as add-on therapy in patients with type 2 diabetes with inadequate glycemic control with metformin alone. RESEARCH DESIGN AND METHODS: This was a randomized, double-blind, placebo-controlled study of saxagliptin (2.5, 5, o...

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Bibliographic Details
Published in:	Diabetes care Vol. 32; no. 9; pp. 1649 - 1655
Main Authors:	DeFronzo, Ralph A, Hissa, Miguel N, Garber, Alan J, Luiz Gross, Jorge, Yuyan Duan, Raina, Ravichandran, Shoba, Chen, Roland S
Format:	Journal Article
Language:	English
Published:	Alexandria, VA American Diabetes Association 01-09-2009
Subjects:	Adamantane - administration & dosage Adamantane - adverse effects Adamantane - analogs & derivatives Adamantane - pharmacology Adamantane - therapeutic use Adolescent Adult Aged Apoptosis Biological and medical sciences Blood Glucose - drug effects Care and treatment Dextrose Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes therapy Diabetes. Impaired glucose tolerance Diabetics Dipeptides - administration & dosage Dipeptides - adverse effects Dipeptides - pharmacology Dipeptides - therapeutic use Double-Blind Method Drug abuse Drug therapy Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Glucose Heart failure Humans Hypoglycemia Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Male Medical research Medical sciences Medicine, Experimental Metabolic diseases Metformin - administration & dosage Metformin - adverse effects Metformin - pharmacology Metformin - therapeutic use Middle Aged Miscellaneous Original Research Patient care planning Pharmaceutical industry Physical examinations Placebos Public health. Hygiene Public health. Hygiene-occupational medicine Research methodology Safety Substance abuse treatment Treatment Outcome Type 2 diabetes Young Adult United States Switzerland Dipeptidyl-peptidase IV Endocrinopathy Type 2 diabetes Human Nutrition Enzyme Toxicity Treatment efficiency Enzyme inhibitor Controlled diabetes Patient Metabolic diseases Peptidases Hypoglycemic agent Biguanides Treatment Gliptine derivatives Hydrolases Dipeptidyl-peptidase IV inhibitor Metformin Safety Endocrinology Saxagliptin
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