Protein-Based Salivary Profiles as Novel Biomarkers for Oral Diseases

• Published in: Disease markers Vol. 2018; no. 2018; pp. 1 - 22
• Main Authors: García-García, Abel, Alonso-Sampedro, Manuela, García-Vence, María, Lopez Jornet, Pia, Bravo, Susana B., Pérez-Sayáns, Mario, Lorenzo-Pouso, Alejandro I., Carballo, Javier
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2018; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Aprotinin; Bioindicators; Biological markers; Biology; Biomarkers; Biomarkers - metabolism; Dental caries; Diseases; Enzymes; Ethylenediaminetetraacetic acid; Humans; Medical research; Molecular biology; Mouth Diseases - diagnosis; Mouth Diseases - metabolism; Oral cancer; Oral diseases; Peptides; Peptides - analysis; Periodontal disease; Periodontal Diseases - diagnosis; Periodontal Diseases - metabolism; Periodontics; Physiology; Population; Proteins; Proteins - analysis; Proteomics; Proteomics - methods; Review; Saliva; Saliva - metabolism; Tooth Diseases - diagnosis; Tooth Diseases - metabolism
• ISSN: 0278-0240; 1875-8630
• DOI: 10.1155/2018/6141845

The Global Burden of Oral Diseases affects 3.5 billion people worldwide, representing the number of people affected by the burden of untreated dental caries, severe periodontal disease, and edentulism. Thus, much more efforts in terms of diagnostics and treatments must be provided in the fight of these outcomes. In this sense, recently, the study of saliva as biological matrix has been identified as a new landmark initiative in the search of novel and useful biomarkers to prevent and diagnose these conditions. Specifically, saliva is a rich reservoir of different proteins and peptides and accessible due to recent advances in molecular biology and specially in targeted and unbiased proteomics technologies. Nonetheless, emerging barriers are an obstacle to the study of the salivary proteome in an effective way. This review aims at giving an overall perspective of salivary biomarkers identified in several oral diseases by means of molecular biology approaches.