A live vaccine against Neospora caninum abortions in cattle

• Published in: Vaccine Vol. 33; no. 11; pp. 1299 - 1301
• Main Authors: Reichel, Michael P, Moore, Dadín P, Hemphill, Andrew, Ortega-Mora, Luis M, Dubey, J.P, Ellis, John T
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 10-03-2015; Elsevier Limited
• Subjects: Abortion; Abortion, Veterinary - prevention & control; Allergy and Immunology; Animal diseases; Animal welfare; Animals; Antigens; Cattle; Coccidiosis - prevention & control; Coccidiosis - veterinary; Female; Infections; Livestock; Neospora - immunology; Parasites; Parasitic diseases; Pharmaceutical industry; Pregnancy; Protozoan Vaccines - administration & dosage; Sheep; Studies; Toxoplasmosis; Vaccines; Vaccines, Attenuated - administration & dosage; Veterinarians
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2015.01.064

For many livestock diseases, live vaccines are used as effective tools for the prevention of serious disease, such as toxoplasmosis, theileriosis, babesiosis and coccidiosis [7]. [...]attenuated strains have proven to be useful in preventing abortions in neosporosis [15,16]. Ultimately, safety and efficacy need to be shown in the target species, i.e. primarily cattle. [...]proof-of-concept" studies in the rodent model, although possibly an important staging point in the decision making process of the pharmaceutical industry, have to be treated with caution, and do not necessarily predict the outcomes in cattle [18], and their utility might thus be queried even on animal welfare grounds.