Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome

Rationale Studies in the Fmr1 knockout (KO) mouse, a model of fragile X syndrome (FXS), suggest that excessive signaling through group I metabotropic glutamate receptors (mGluRs), comprised of subtypes mGluR1 and mGluR5, may play a role in the pathogenesis of FXS. Currently, no studies have assessed...

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Bibliographic Details
Published in:	Psychopharmacologia Vol. 219; no. 1; pp. 47 - 58
Main Authors:	Thomas, Alexia M., Bui, Nghiem, Perkins, Jennifer R., Yuva-Paylor, Lisa A., Paylor, Richard
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01-01-2012 Springer Springer Nature B.V
Subjects:	Acoustic Stimulation - methods Amino acids Animal behavior Animal models Animals Antagonists Auditory stimuli Biological and medical sciences Biomedical and Life Sciences Biomedicine Data processing Disease Models, Animal Dose-Response Relationship, Drug Epilepsy fragile X mental retardation protein Fragile X Mental Retardation Protein - genetics Fragile X syndrome Fragile X Syndrome - genetics Fragile X Syndrome - psychology Glutamate Glutamic acid receptors (metabotropic) Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Miscellaneous Motor skill learning Neurosciences Original Investigation Pathogenesis Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Psychiatry Quinolines - pharmacology Receptor, Metabotropic Glutamate 5 Receptors, Metabotropic Glutamate - antagonists & inhibitors Receptors, Metabotropic Glutamate - physiology Reflex, Startle - drug effects Reflex, Startle - physiology Rodents Seizures Seizures (Medicine) Behavior Mouse Fragile X Metabotropic glutamate receptor Fmr1 Fmrl Chromosome fragility Animal model Group I mglu glutamate receptor Rodentia Glutamate receptor Vertebrata Mammalia Metabotropic receptor Animal Antagonist Fragile X syndrome
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