BAY 41‐2272, a soluble guanylate cyclase agonist, activates human mononuclear phagocytes

BACKGROUND AND PURPOSE Phagocyte function is critical for host defense against infections. Defects in phagocytic function lead to several primary immunodeficiencies characterized by early onset of recurrent and severe infections. In this work, we further investigated the effects of BAY 41‐2272, a so...

Full description

Saved in:

Bibliographic Details
Published in:	British journal of pharmacology Vol. 166; no. 5; pp. 1617 - 1630
Main Authors:	Soeiro‐Pereira, PV, Falcai, A, Kubo, CA, Oliveira‐Júnior, EB, Marques, OC, Antunes, E, Condino‐Neto, A
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-07-2012 Nature Publishing Group
Subjects:	BAY 41‐2272 Biological and medical sciences Cell Line Cell Survival - drug effects Cells, Cultured cGMP Escherichia coli Escherichia coli - drug effects Gene expression gp91PHOX Guanylate Cyclase - metabolism Humans Infections Interleukin-12 - metabolism Medical sciences Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism microbicidal activity Monocytes - drug effects Monocytes - physiology NADPH oxidase NADPH Oxidase 2 NADPH Oxidases - genetics NADPH Oxidases - metabolism Nitric oxide p67PHOX Phagocytosis - drug effects Pharmacology. Drug treatments Phosphoproteins - metabolism Pyrazoles - pharmacology Pyridines - pharmacology Research Papers RNA, Messenger - metabolism Superoxides - metabolism Tumor Necrosis Factor-alpha - metabolism Human Agonist Enzyme Phosphorus-oxygen lyases 3',5'-GMP cGMP Lyases Guanylate cyclase microbicidal activity NAD(P)H oxidase p67 gp91 NADPH oxidase BAY 41-2272 Oxidoreductases Phagocyte
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!