Azithromycin, clarithromycin and telithromycin inhibit MUC5AC induction by Chlamydophila pneumoniae in airway epithelial cells

Abstract Background Airway mucus hypersecretion is an important problem in chronic respiratory diseases including bronchial asthma. Chlamydophila pneumoniae is recently confirmed to be a pathogen in bronchial asthma, but the relationship between C. pneumoniae and mucus hypersecretion is uncertain. I...

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Bibliographic Details
Published in:	Pulmonary pharmacology & therapeutics Vol. 22; no. 6; pp. 580 - 586
Main Authors:	Morinaga, Yoshitomo, Yanagihara, Katsunori, Miyashita, Naoyuki, Seki, Masafumi, Izumikawa, Koichi, Kakeya, Hiroshi, Yamamoto, Yoshihiro, Mukae, Hiroshi, Yamada, Yasuaki, Kohno, Shigeru, Kamihira, Shimeru
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-12-2009
Subjects:	Animals Anti-Bacterial Agents - pharmacology Asthma Azithromycin - pharmacology Blotting, Western Cells, Cultured Chlamydophila Infections - metabolism Chlamydophila pneumoniae Clarithromycin - pharmacology Enzyme-Linked Immunosorbent Assay Epithelial Cells - drug effects Extracellular Signal-Regulated MAP Kinases - biosynthesis Gene Expression - drug effects Immunomodulatory effects Ketolides Ketolides - pharmacology Macrolides Medical Education Mice Mucin 5AC - biosynthesis Mucin 5AC - genetics Mucins NF-kappa B - metabolism NF-kappa B p50 Subunit - biosynthesis NF-kappa B p50 Subunit - genetics Pulmonary/Respiratory Respiratory Mucosa - cytology Respiratory Mucosa - drug effects Reverse Transcriptase Polymerase Chain Reaction Transcription Factor RelA - biosynthesis Transcription Factor RelA - genetics Immunomodulatory effects Ketolides Macrolides Mucins Asthma
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