Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells

Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean–Congo haemorrhagic fever virus (CCHFV). Here we report that the Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing a vital role in...

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Bibliographic Details
Published in:	Nature microbiology Vol. 9; no. 6; pp. 1499 - 1512
Main Authors:	Monteil, Vanessa M., Wright, Shane C., Dyczynski, Matheus, Kellner, Max J., Appelberg, Sofia, Platzer, Sebastian W., Ibrahim, Ahmed, Kwon, Hyesoo, Pittarokoilis, Ioannis, Mirandola, Mattia, Michlits, Georg, Devignot, Stephanie, Elder, Elizabeth, Abdurahman, Samir, Bereczky, Sándor, Bagci, Binnur, Youhanna, Sonia, Aastrup, Teodor, Lauschke, Volker M., Salata, Cristiano, Elaldi, Nazif, Weber, Friedemann, Monserrat, Nuria, Hawman, David W., Feldmann, Heinz, Horn, Moritz, Penninger, Josef M., Mirazimi, Ali
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 2024 Nature Publishing Group
Subjects:	13/1 13/31 14/63 631/326/596/2555 631/326/596/2557 64/60 96/10 Animals Apolipoprotein E Apolipoproteins E - genetics Apolipoproteins E - metabolism Biomedical and Life Sciences Biosensors Blood vessels Cell culture Climate change Crimean hemorrhagic fever Fever Glycoproteins Hemorrhagic Fever Virus, Crimean-Congo - genetics Hemorrhagic Fever Virus, Crimean-Congo - physiology Hemorrhagic Fever, Crimean - metabolism Hemorrhagic Fever, Crimean - virology Humans Infections Infectious Diseases LDLR protein Life Sciences Low density lipoprotein Low density lipoprotein receptors Medical Microbiology Medicin och hälsovetenskap Mice Mice, Knockout Microbiology Organoids Parasitology Population density Receptor density Receptors, LDL - genetics Receptors, LDL - metabolism Receptors, Virus - metabolism Ticks - metabolism Ticks - virology Virology Virus Internalization Viruses
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