Predictors of osteoporotic fracture in postmenopausal women: a meta-analysis

• Published in: Journal of orthopaedic surgery and research Vol. 18; no. 1; p. 574
• Main Authors: Long, Guanghua, Liu, Chong, Liang, Tuo, Zhang, Zide, Qin, Zhaojie, Zhan, Xinli
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05-08-2023; BioMed Central; BMC
• Subjects: Age; Analysis; Bias; Bone Density; Cohort analysis; Complications; Denosumab; Diabetes mellitus; Dietary supplements; Disodium pamidronate; Estrogen; Estrogens; Female; Fractures; Health aspects; Hip joint; Humans; Menarche; Menopause; Meta-analysis; Orthopedics; Osteoporosis; Osteoporosis - complications; Osteoporosis, Postmenopausal - complications; Osteoporosis, Postmenopausal - diagnosis; Osteoporosis, Postmenopausal - epidemiology; Osteoporotic fracture; Osteoporotic Fractures - epidemiology; Osteoporotic Fractures - etiology; Osteoporotic Fractures - prevention & control; Post-menopause; Postmenopausal women; Postmenopause; Predictors; Prevention; Risk Factors; Risk groups; Standard deviation; Systematic Review; Vitamin D; Womens health; Postmenopausal women; Osteoporotic fracture; Meta-analysis; Predictors
• ISSN: 1749-799X; 1749-799X
• DOI: 10.1186/s13018-023-04051-6

Osteoporosis affects more than 200 million women worldwide, with postmenopausal women being particularly susceptible to this condition and its severe sequelae disproportionately, such as osteoporotic fractures. To date, the current focus has been more on symptomatic treatment, rather than preventive measures. To address this, we performed a meta-analysis aiming to identify potential predictors of osteoporotic fractures in postmenopausal women, with the ultimate goal of identifying high-risk patients and exploring potential therapeutic approaches. We searched Embase, MEDLINE and Cochrane with search terms (postmenopausal AND fracture) AND ("risk factor" OR "predictive factor") in May 2022 for cohort and case-control studies on the predictors of osteoporotic fracture in postmenopausal women. Ten studies with 1,287,021 postmenopausal women were found eligible for analyses, in which the sample size ranged from 311 to 1,272,115. The surveyed date spanned from 1993 to 2021. Our results suggested that age, BMI, senior high school and above, parity ≥ 3, history of hypertension, history of diabetes mellitus, history of alcohol intake, age at menarche ≥ 15, age at menopause < 40, age at menopause > 50, estrogen use and vitamin D supplements were significantly associated with osteoporotic fracture in postmenopausal women. Our findings facilitate the early prediction of osteoporotic fracture in postmenopausal women and may contribute to potential therapeutic approaches. By focusing on preventive strategies and identifying high-risk individuals, we can work toward reducing the burden of osteoporosis-related fractures in this vulnerable population.