A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine
Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization. Thus, integrative pharmacology-based traditional Chinese medicine (TCMIP) was proposed as a paradigm shift in TCM. This review focuse...
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| Published in: | Acta pharmaceutica Sinica. B Vol. 11; no. 6; pp. 1379 - 1399 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
01-06-2021
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| Abstract | Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization. Thus, integrative pharmacology-based traditional Chinese medicine (TCMIP) was proposed as a paradigm shift in TCM. This review focuses on the presentation of this novel concept and the main research contents, methodologies and applications of TCMIP. First, TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics–pharmacodynamics (PK–PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK–PD processes in vivo. Then, the main research contents of TCMIP are introduced as follows: chemical and ADME/PK profiles of TCM formulas; confirming the three forms of active substances and the three action modes; establishing the qualitative PK–PD correlation; and building the quantitative PK–PD correlations, etc. After that, we summarize the existing data resources, computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods. Finally, we further discuss the applications of TCMIP for the improvement of TCM quality control, clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs, especially TCM-related combination drug discovery.
This review focuses on the presentation of the novel concept and the main research contents, methodologies and applications of integrative pharmacology-based traditional Chinese medicine. [Display omitted] |
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| AbstractList | Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization. Thus, integrative pharmacology-based traditional Chinese medicine (TCMIP) was proposed as a paradigm shift in TCM. This review focuses on the presentation of this novel concept and the main research contents, methodologies and applications of TCMIP. First, TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics–pharmacodynamics (PK–PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK–PD processes in vivo. Then, the main research contents of TCMIP are introduced as follows: chemical and ADME/PK profiles of TCM formulas; confirming the three forms of active substances and the three action modes; establishing the qualitative PK–PD correlation; and building the quantitative PK–PD correlations, etc. After that, we summarize the existing data resources, computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods. Finally, we further discuss the applications of TCMIP for the improvement of TCM quality control, clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs, especially TCM-related combination drug discovery.
This review focuses on the presentation of the novel concept and the main research contents, methodologies and applications of integrative pharmacology-based traditional Chinese medicine. [Display omitted] Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization. Thus, integrative pharmacology-based traditional Chinese medicine (TCMIP) was proposed as a paradigm shift in TCM. This review focuses on the presentation of this novel concept and the main research contents, methodologies and applications of TCMIP. First, TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics–pharmacodynamics (PK–PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK–PD processes in vivo . Then, the main research contents of TCMIP are introduced as follows: chemical and ADME/PK profiles of TCM formulas; confirming the three forms of active substances and the three action modes; establishing the qualitative PK–PD correlation; and building the quantitative PK–PD correlations, etc. After that, we summarize the existing data resources, computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods. Finally, we further discuss the applications of TCMIP for the improvement of TCM quality control, clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs, especially TCM-related combination drug discovery. This review focuses on the presentation of the novel concept and the main research contents, methodologies and applications of integrative pharmacology-based traditional Chinese medicine. Image 1 Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization. Thus, integrative pharmacology-based traditional Chinese medicine (TCMIP) was proposed as a paradigm shift in TCM. This review focuses on the presentation of this novel concept and the main research contents, methodologies and applications of TCMIP. First, TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics–pharmacodynamics (PK–PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK–PD processes in vivo. Then, the main research contents of TCMIP are introduced as follows: chemical and ADME/PK profiles of TCM formulas; confirming the three forms of active substances and the three action modes; establishing the qualitative PK–PD correlation; and building the quantitative PK–PD correlations, etc. After that, we summarize the existing data resources, computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods. Finally, we further discuss the applications of TCMIP for the improvement of TCM quality control, clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs, especially TCM-related combination drug discovery. |
| Author | Du, Xia Zhang, Junhong Liu, Changxiao Zhang, Yanqiong Chen, Hong Xu, Haiyu Zhang, Luoqi Liu, Feng Wang, Ping Yang, Hongjun Zhao, Chunhui Wu, Dan |
| Author_xml | – sequence: 1 givenname: Haiyu surname: Xu fullname: Xu, Haiyu email: hyxu@icmm.ac.cn organization: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China – sequence: 2 givenname: Yanqiong surname: Zhang fullname: Zhang, Yanqiong organization: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China – sequence: 3 givenname: Ping surname: Wang fullname: Wang, Ping organization: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China – sequence: 4 givenname: Junhong surname: Zhang fullname: Zhang, Junhong organization: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China – sequence: 5 givenname: Hong surname: Chen fullname: Chen, Hong organization: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China – sequence: 6 givenname: Luoqi surname: Zhang fullname: Zhang, Luoqi organization: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China – sequence: 7 givenname: Xia surname: Du fullname: Du, Xia organization: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China – sequence: 8 givenname: Chunhui surname: Zhao fullname: Zhao, Chunhui organization: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China – sequence: 9 givenname: Dan surname: Wu fullname: Wu, Dan organization: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China – sequence: 10 givenname: Feng surname: Liu fullname: Liu, Feng organization: Shaanxi Institute of International Trade & Commerce, Xianyang 7120462, China – sequence: 11 givenname: Hongjun surname: Yang fullname: Yang, Hongjun organization: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China – sequence: 12 givenname: Changxiao surname: Liu fullname: Liu, Changxiao email: liuchangxiao@163.com organization: State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China |
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| Cites_doi | 10.1016/j.bioorg.2020.103589 10.1093/bioinformatics/bti273 10.2174/1389200211209050558 10.1016/j.phymed.2018.03.002 10.1002/elps.201000122 10.1172/JCI108081 10.1186/1758-2946-6-13 10.1016/j.msec.2016.07.072 10.1021/mp500783g 10.3390/molecules24224098 10.1016/j.jpba.2011.06.008 10.1101/gr.1239303 10.1016/j.cell.2018.03.042 10.1093/nar/gkj067 10.1038/s41591-019-0509-0 10.2174/138920011797470083 10.1002/jssc.201300794 10.1016/j.chroma.2013.05.001 10.1016/j.jep.2018.09.035 10.1002/jcc.21643 10.1038/s41467-019-09234-6 10.1016/j.drudis.2015.01.009 10.1007/s00228-014-1786-7 10.1016/j.phymed.2018.01.019 10.3389/fphar.2019.00049 10.1063/1.5081098 10.1186/1752-0509-6-92 10.1016/j.chroma.2018.01.040 10.1016/j.jchromb.2013.07.015 10.1016/j.drudis.2011.09.007 10.3390/ijms20081912 10.1016/j.chroma.2015.12.016 10.1186/s12864-017-3512-1 10.3390/molecules200610047 10.3390/molecules25030577 10.1136/gutjnl-2011-301805 10.1016/S1674-6384(17)60070-4 10.1089/omi.2011.0138 10.1038/nprot.2016.136 10.1038/nprot.2008.211 10.1093/nar/gkw1012 10.1002/cpbi.27 10.1093/nar/gkv1277 10.1186/alzrt54 10.1186/1471-2105-7-488 10.3724/SP.J.1009.2013.00110 10.1186/s13065-018-0417-2 10.1038/aps.2017.117 10.1038/srep21146 10.1016/j.ijbiomac.2020.10.113 10.1021/acs.jafc.9b01661 10.1023/A:1011907920641 10.1038/s41419-019-1638-6 10.1016/S0169-409X(03)00121-2 10.1038/75556 10.1093/bioinformatics/bti098 10.1016/j.bja.2017.11.100 10.1093/bioinformatics/btw151 10.1016/j.biopha.2019.109252 10.1016/j.jpba.2018.12.043 10.1016/j.apsb.2019.10.001 10.1093/nar/gkr1088 10.1016/j.jep.2018.07.008 10.1016/j.vaa.2018.09.042 10.1093/nar/gky1131 10.1038/nrg.2017.38 10.1097/00007691-200312000-00005 10.1126/science.1188302 10.1517/17425255.4.6.759 10.1016/j.apsb.2016.05.005 10.1016/j.apsb.2020.05.012 10.1080/17460441.2017.1245721 10.1038/s41576-019-0122-6 10.1039/a902202c 10.1016/j.physrep.2019.12.004 10.1039/c2lc40074j 10.1093/nar/gky987 10.1080/17460441.2017.1253676 10.1038/s41598-019-46507-y 10.1038/nm.2471 10.1016/j.ijbiomac.2017.01.149 10.1177/0091270010382913 10.1093/bib/bbaa082 10.1128/AAC.48.10.3850-3857.2004 10.1016/j.ejps.2005.08.011 10.1128/AAC.05035-14 10.1039/C6NP00001K 10.1016/j.tig.2016.06.003 10.1016/j.phrs.2019.02.024 10.2147/DDDT.S182965 10.1007/s11095-011-0394-9 10.1039/b917763a 10.1093/bib/bbp063 10.1242/dmm.038224 10.1002/cpt.1693 10.1038/s41598-019-52375-3 10.1093/nar/gkv1072 10.1007/978-1-0716-0239-3_17 10.1124/dmd.108.021592 10.1039/C4MB00287C 10.1023/A:1013611617787 10.1186/s13063-020-4208-4 10.1093/nar/gkr930 10.1016/j.bcp.2013.02.021 10.2174/1381612811319230004 10.1016/S0378-5173(01)00897-3 10.1016/j.biomaterials.2017.11.010 10.1093/nar/gky1105 10.1017/S0007114516004037 10.1093/nar/gky1075 10.1021/acs.molpharmaceut.5b00861 10.7326/IsTranslatedFrom_M17-2977_2 10.1093/nar/gkh086 10.1093/bioinformatics/btt703 10.1038/nbt.2989 10.2174/1389200221666200620210522 10.1016/j.phymed.2018.09.026 10.1007/s00018-018-2943-4 10.1056/NEJMc1412035 10.1038/ismej.2014.177 10.1038/aps.2016.165 10.1016/j.febslet.2004.03.067 10.1021/ed100697w 10.2174/1389557515666150511152705 10.1155/2013/658531 10.1080/17425255.2019.1700950 10.1093/nar/gky1049 10.1016/j.chom.2019.07.004 10.1016/j.pharmthera.2020.107698 10.1016/j.apsb.2017.04.012 10.1002/jssc.201500168 10.1016/j.ijbiomac.2018.11.037 10.1007/s10096-019-03623-x 10.1093/nar/gkx1132 10.1016/j.aca.2015.08.048 10.1093/nar/gkz764 10.1038/s41591-019-0559-3 10.1039/c3lc50350j 10.1039/C5MB00460H 10.1093/nar/gkp456 10.1016/S0928-0987(01)00135-X 10.1093/nar/gkn892 10.1016/j.chroma.2019.04.008 |
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| Keywords | Integrative pharmacology-based traditional Chinese medicine Big data Mathematical modeling PK–PD correlations Multidimensional association network |
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| References | Blatti, Sinha (bib121) 2016; 32 Kuentz, Nick, Parrott, Röthlisberger (bib65) 2006; 27 Brommage, Powell, Vogel (bib136) 2019; 12 Xu, Tao, Lu, Wang, Zhang, Yuan (bib150) 2013; 2013 Ghalmane, Cherifi, Cherifi, Hassouni (bib126) 2019; 9 Wright, Sieber (bib103) 2016; 33 Szklarczyk, Gable, Lyon, Junge, Wyder, Huerta-Cepas (bib111) 2019; 47 Yao, Pan, Wang, Yao, Yang, Hou (bib57) 2018; 1538 Zhao, Li, He, Zhao, Shi, Dong (bib64) 2020; 165 Cui, Li, Cui, Yang, Qin (bib137) 2020; 45 An, Bao, Di, Zhao, Zhao, Zhang (bib31) 2019; 118 LeCluyse (bib73) 2001; 13 Zhang, Yu, Li, Zhang, Zhao, Zhao (bib99) 2021; 22 da Silva Junior, Dezani, Dezani, dos Reis Serra (bib77) 2015; 15 Xu, Hou, Li, Shen, Tang, Guo (bib142) 2019; 25 Du, Yuan, Ma, Song, Xie, Chen (bib96) 2014; 10 Li, Chen, Liu, Rui (bib62) 2019; 123 Shen, Mo, Tang, Zhang, Pang, Qian (bib38) 2013; 1297 Li, Meng, Yang, Liu, Hou, Tang (bib40) 2019; 9 Yang, Liu, He (bib55) 2019; 24 Tian, Shi, Zhang, Wang (bib1) 2010; 2 Wishart, Knox, Guo, Shrivastava, Hassanali, Stothard (bib85) 2006; 34 Sudsakorn, Bahadduri, Fretland, Lu (bib106) 2020; 21 Siopi, Siafakas, Vourli, Zerva, Meletiadis (bib128) 2015; 59 Serrano-Rodríguez, Mengual, Quirós-Carmona, Fernández, Domínguez, Serrano-Caballero (bib71) 2019; 46 Piñero, Ramírez-Anguita, Saüch-Pitarch, Ronzano, Centeno, Sanz (bib110) 2020; 48 Liu, Yi, Si, Xiao, He, Li (bib18) 2011; 12 Zhi, Huang, Wang, Cao, Bai, Guo (bib34) 2019; 38 Liu, Zeng (bib76) 2008; 43 Yang, Zhang, Wu, Huang, Guo, Liu (bib45) 2017; 7 Xu, Lian, Zhao, Zhao, Chen, Zhang (bib17) 2015; 9 Fabregat, Jupe, Matthews, Sidiropoulos, Gillespie, Garapati (bib97) 2018; 46 Cowen, Ideker, Raphael, Sharan (bib123) 2017; 18 Carmichael, Charles, Tett (bib69) 2003; 25 Huang, Zhang, Ma, Yang, He, Tian (bib70) 2019; 13 Sung, Kam, Shuler (bib131) 2010; 10 Shannon, Markiel, Ozier, Baliga, Wang, Ramage (bib124) 2003; 13 Yamamura (bib135) 2003; 55 Xu, Zhang, Liu, Chen, Lv, Tang (bib50) 2019; 47 Takakura (bib27) 2011; 28 Wang, Li, Tao, Li, Zhang, Xu (bib20) 2019; 236 Chong, Xia (bib89) 2020; 2104 Beuming, Skrabanek, Niv, Mukherjee, Weinstein (bib118) 2005; 21 Li, Li, Su, Xiao, Peng, Liu (bib143) 2018; 44 Sun, Liu, Sun, Li, Wang (bib58) 2016; 1427 Liu, Cheng, Guo, Zhang, Li, Hou (bib141) 2017; 9 Ingels, Deferme, Destexhe, Oth, van den Mooter, Augustijns (bib72) 2002; 232 Sjögren, Thörn, Tannergren (bib66) 2016; 13 Shaikh, Dhavan, Pavale, Ramana, Jadhav (bib67) 2020; 96 Eraslan, Avsec, Gagneur, Theis (bib44) 2019; 20 Krämer, Green, Pollard, Tugendreich (bib122) 2014; 30 Qiu, Yang, Shi, Yao, Yang, Liu (bib59) 2015; 893 Petukh, Stefl, Alexov (bib23) 2013; 19 Shen, Qu, Harata-Lee, Cui, Aung, Wang (bib42) 2019; 9 Chen, Pandey, Nguyen (bib112) 2017; 18 Liu, Guo, Wang, Li, Zhang, Li (bib52) 2016; 6 Zhou, Zhou, Pache, Chang, Khodabakhshi, Tanaseichuk (bib125) 2019; 10 Guo, Zhang, Su, Xu, Yang (bib155) 2019; 10 Feng, Ao, Peng, Yan (bib30) 2019; 142 Bron, Kleerebezem, Brummer, Cani, Mercenier, MacDonald (bib32) 2017; 117 Brohée, van Helden (bib120) 2006; 7 Zhu, Huang (bib7) 2014; 371 Zhi, Deng, Yan, Li, Han, Zhang (bib37) 2019; 166 Hans, Grabley (bib6) 2000; 156 Wang, Zhang, Sun (bib13) 2012; 16 (bib91) 2019; 47 Huh, Matthews, Mammoto, Montoya-Zavala, Hsin, Ingber (bib83) 2010; 328 Rappaport, Twik, Plaschkes, Nudel, Iny Stein, Levitt (bib109) 2017; 45 Mendez, Gaulton, Bento, Chambers, De Veij, Félix (bib51) 2019; 47 Derendorf, Meibohm (bib132) 1999; 16 Wang, Shang, Li, Zhang, Dong, Cui (bib39) 2020; 10 Siebert, Gerhäuser, Simon, Wagener, Weber, Sauter (bib93) 2016; 28 Wu, Wang, Liu, Tang, Fang, Zhao (bib157) 2015; 20 Wu, Sun, Li, Wang, Jia, Lai (bib98) 2020; 48 Patridge, Gareiss, Kinch, Hoyer (bib2) 2016; 21 Guryanov, Fiorucci, Tennikova (bib24) 2016; 68 Tu (bib3) 2011; 17 Diallinas (bib22) 2016; 32 Li, Zhang (bib10) 2013; 11 Li, Wang, Zhai, Xiao, Zhang, Li (bib156) 2017; 31 Thingholm, Rühlemann, Koch, Fuqua, Laucke, Boehm (bib104) 2019; 26 Ashburner, Ball, Blake, Botstein, Butler, Cherry (bib95) 2000; 25 Lepage, Leclerc, Joossens, Mondot, Blottière, Raes (bib36) 2013; 62 Lee, Choi, Sung (bib130) 2019; 15 Qu, An, Luo, Lu, Liu, Zhao (bib81) 2018; 155 Xiao, Kexuan, Qiang, Yunan, Center (bib139) 2016; 9 Wang, Sun, Zhang, Li, Wang, Shi (bib145) 2013; 36 Huang, Fan, Wang, Liang, Tong, Bai (bib47) 2017; 38 Poyet, Groussin, Gibbons, Avila-Pacheco, Jiang, Kearney (bib100) 2019; 25 Salwinski, Miller, Smith, Pettit, Ju, Eisenberg (bib117) 2004; 32 Lv, Jia, Li, Kuai, Li, Guo (bib35) 2019; 10 Tao, Xu, Wang, Wang, Zhang, Wang (bib148) 2013; 935 Qi, Yun, Sun, Xia, Wu, Wang (bib105) 2019; 25 Zhang, Wong (bib25) 2017; 12 Köhler, Carmody, Vasilevsky, Jacobsen, Danis, Gourdine (bib107) 2019; 47 Ru, Li, Wang, Zhou, Li, Huang (bib11) 2014; 6 Liu, Ma, Zhao, Ruth, Zhang, Cheng (bib43) 2020; 846 Gutteridge, Thornton (bib26) 2004; 567 Yeon, Na, Park (bib80) 2010; 31 Gashaw, Ellinghaus, Sommer, Asadullah (bib21) 2011; 16 Williams, Potter (bib5) 1975; 56 Roblek, Vaupotic, Mrhar, Lainscak (bib102) 2015; 71 Li, Yuen, Goulay-Dufaÿ, Sheng, Standing, Kwok (bib133) 2018; 120 Cheng, Wu, Shang, Li, Altman, Moher (bib8) 2017; 167 Gilson, Liu, Baitaluk, Nicola, Hwang, Chong (bib88) 2016; 44 Agarwal, Goss, Cho, McCain, Parker (bib82) 2013; 13 Dong, Ruan, Ding, Zhao, Hao, Zhang (bib56) 2020; 25 Yu, Li, Guo, Di, Qin, Li (bib54) 2019; 1599 Brunner, Langer, Dobrozemsky, Müller, Zeitlinger, Mitterhauser (bib84) 2004; 48 Zhang, Zhou, Lu, Ji, Niu, Zha (bib28) 2012; 13 Chen, Quan, Zhou, Zhao, Chen, Hu (bib61) 2019; 234 Tyanova, Temu, Cox (bib90) 2016; 11 Brown, Jurisica (bib114) 2005; 21 Newman, Cragg, Snader (bib4) 2000; 17 Das, Yu (bib113) 2012; 6 Caruso, Alvarez-Sánchez, Hillebrecht, Poirier, Schuler, Lavé (bib129) 2013; 85 Guo, Zhang, Su, Xu, Zhang, Zhang (bib144) 2018; 44 Xu, Zhang, Li, Lv, Zhang, Wang (bib153) 2020; 99 Xu, Yang, Zhang, Jia, Li, Zhang (bib151) 2016; 12 Szklarczyk, Santos, von Mering, Jensen, Bork, Kuhn (bib86) 2016; 44 Wang, Zhang, Yu, Li, Su, Zhang (bib149) 2019; 53 Plewczynski, Łaźniewski, Augustyniak, Ginalski (bib101) 2011; 32 Zhao, Li, Zhang, Huang, Zhang, Zhao (bib16) 2020; 216 Lu, Yang, Gao, Chen, Du, Sun (bib46) 2008; 36 Huang, Sherman, Lempicki (bib94) 2009; 4 Licata, Briganti, Peluso, Perfetto, Iannuccelli, Galeota (bib115) 2012; 40 Burge, Gunasekaran, Eckert, Chaaban (bib33) 2019; 20 Bhatia, Ingber (bib78) 2014; 32 Zhao, Jiang, Zhang (bib9) 2010; 11 Zhao, Feng, Shan, Cheng, Wang, Zhao (bib138) 2015; 38 Zhang, Xu, Chen, D S (bib146) 2012; 6 Stilo, Liberto, Tao, Bicchi, Cordero (bib60) 2019; 67 Xu, Yang (bib14) 2014; 39 Keshava Prasad, Goel, Kandasamy, Keerthikumar, Kumar, Mathivanan (bib116) 2009; 37 Zhang, Guo, Li, Ren, Tang, Wang (bib154) 2018; 39 Bröhl, Lehnertz (bib127) 2019; 29 Wang, Zhang, Li, Zhou, Zhang, Wang (bib87) 2020; 48 Haidar, Johnson, Fossler, Hussain (bib134) 2002; 19 Hutter, Zenklusen (bib92) 2018; 173 Pence, Williams (bib48) 2010; 87 Kim, Huh, Hamilton, Ingber (bib79) 2012; 12 Jiao, Wang, Jiang, Liu (bib74) 2018; 12 Kaisar, Sajja, Prasad, Abhyankar, Liles, Cucullo (bib75) 2017; 12 Wang, Tang, Su, Zhang, Cui, Xu (bib15) 2018; 43 Liu, Shang, Yang, Wu, Zhao (bib63) 2017; 98 Kerrien, Aranda, Breuza, Bridge, Broackes-Carter, Chen (bib119) 2012; 40 Hosey, Benet (bib68) 2015; 12 Wang, Wang, Wang, Li, Yu, Hu (bib152) 2020; 21 Wang, Xiao, Suzek, Zhang, Wang, Bryant (bib49) 2009; 37 Taskar, Pilla Reddy, Burt, Posada, Varma, Zheng (bib41) 2020; 107 Hou, Wang (bib19) 2008; 4 Yang, Qiao, Li, Fan, Bo, Guo (bib53) 2016; 6 Amberger, Hamosh (bib108) 2017; 58 Zhang, Xu, Chen, Chen, Wang, Meng (bib147) 2011; 56 Wang, Liu, Cheng, Wang (bib12) 2011; 51 Liu, Chen, Xiao, Zhang, Liao (bib140) 2016; 47 Adak, Khan (bib29) 2019; 76 Sun (10.1016/j.apsb.2021.03.024_bib58) 2016; 1427 Zhang (10.1016/j.apsb.2021.03.024_bib28) 2012; 13 Wright (10.1016/j.apsb.2021.03.024_bib103) 2016; 33 Haidar (10.1016/j.apsb.2021.03.024_bib134) 2002; 19 Hans (10.1016/j.apsb.2021.03.024_bib6) 2000; 156 Fabregat (10.1016/j.apsb.2021.03.024_bib97) 2018; 46 Xiao (10.1016/j.apsb.2021.03.024_bib139) 2016; 9 Qiu (10.1016/j.apsb.2021.03.024_bib59) 2015; 893 Xu (10.1016/j.apsb.2021.03.024_bib150) 2013; 2013 Mendez (10.1016/j.apsb.2021.03.024_bib51) 2019; 47 da Silva Junior (10.1016/j.apsb.2021.03.024_bib77) 2015; 15 Yang (10.1016/j.apsb.2021.03.024_bib45) 2017; 7 Lu (10.1016/j.apsb.2021.03.024_bib46) 2008; 36 Xu (10.1016/j.apsb.2021.03.024_bib50) 2019; 47 Siopi (10.1016/j.apsb.2021.03.024_bib128) 2015; 59 Wang (10.1016/j.apsb.2021.03.024_bib20) 2019; 236 Piñero (10.1016/j.apsb.2021.03.024_bib110) 2020; 48 Huang (10.1016/j.apsb.2021.03.024_bib94) 2009; 4 Du (10.1016/j.apsb.2021.03.024_bib96) 2014; 10 Bröhl (10.1016/j.apsb.2021.03.024_bib127) 2019; 29 Pence (10.1016/j.apsb.2021.03.024_bib48) 2010; 87 Köhler (10.1016/j.apsb.2021.03.024_bib107) 2019; 47 Thingholm (10.1016/j.apsb.2021.03.024_bib104) 2019; 26 Xu (10.1016/j.apsb.2021.03.024_bib142) 2019; 25 Lee (10.1016/j.apsb.2021.03.024_bib130) 2019; 15 Shen (10.1016/j.apsb.2021.03.024_bib42) 2019; 9 Liu (10.1016/j.apsb.2021.03.024_bib18) 2011; 12 Yamamura (10.1016/j.apsb.2021.03.024_bib135) 2003; 55 Eraslan (10.1016/j.apsb.2021.03.024_bib44) 2019; 20 Wu (10.1016/j.apsb.2021.03.024_bib98) 2020; 48 Zhou (10.1016/j.apsb.2021.03.024_bib125) 2019; 10 Zhi (10.1016/j.apsb.2021.03.024_bib34) 2019; 38 Wang (10.1016/j.apsb.2021.03.024_bib87) 2020; 48 Yang (10.1016/j.apsb.2021.03.024_bib53) 2016; 6 Wishart (10.1016/j.apsb.2021.03.024_bib85) 2006; 34 Wang (10.1016/j.apsb.2021.03.024_bib13) 2012; 16 Yeon (10.1016/j.apsb.2021.03.024_bib80) 2010; 31 Zhao (10.1016/j.apsb.2021.03.024_bib138) 2015; 38 Bron (10.1016/j.apsb.2021.03.024_bib32) 2017; 117 Yu (10.1016/j.apsb.2021.03.024_bib54) 2019; 1599 Wang (10.1016/j.apsb.2021.03.024_bib149) 2019; 53 Hou (10.1016/j.apsb.2021.03.024_bib19) 2008; 4 Chen (10.1016/j.apsb.2021.03.024_bib61) 2019; 234 Huang (10.1016/j.apsb.2021.03.024_bib47) 2017; 38 Salwinski (10.1016/j.apsb.2021.03.024_bib117) 2004; 32 Wang (10.1016/j.apsb.2021.03.024_bib49) 2009; 37 Feng (10.1016/j.apsb.2021.03.024_bib30) 2019; 142 Gilson (10.1016/j.apsb.2021.03.024_bib88) 2016; 44 Petukh (10.1016/j.apsb.2021.03.024_bib23) 2013; 19 Caruso (10.1016/j.apsb.2021.03.024_bib129) 2013; 85 Ghalmane (10.1016/j.apsb.2021.03.024_bib126) 2019; 9 Kim (10.1016/j.apsb.2021.03.024_bib79) 2012; 12 Guryanov (10.1016/j.apsb.2021.03.024_bib24) 2016; 68 Zhao (10.1016/j.apsb.2021.03.024_bib16) 2020; 216 Hosey (10.1016/j.apsb.2021.03.024_bib68) 2015; 12 Tao (10.1016/j.apsb.2021.03.024_bib148) 2013; 935 Stilo (10.1016/j.apsb.2021.03.024_bib60) 2019; 67 Cui (10.1016/j.apsb.2021.03.024_bib137) 2020; 45 Siebert (10.1016/j.apsb.2021.03.024_bib93) 2016; 28 Adak (10.1016/j.apsb.2021.03.024_bib29) 2019; 76 Shaikh (10.1016/j.apsb.2021.03.024_bib67) 2020; 96 Dong (10.1016/j.apsb.2021.03.024_bib56) 2020; 25 Jiao (10.1016/j.apsb.2021.03.024_bib74) 2018; 12 Tian (10.1016/j.apsb.2021.03.024_bib1) 2010; 2 Liu (10.1016/j.apsb.2021.03.024_bib140) 2016; 47 Sjögren (10.1016/j.apsb.2021.03.024_bib66) 2016; 13 Patridge (10.1016/j.apsb.2021.03.024_bib2) 2016; 21 Bhatia (10.1016/j.apsb.2021.03.024_bib78) 2014; 32 Hutter (10.1016/j.apsb.2021.03.024_bib92) 2018; 173 Das (10.1016/j.apsb.2021.03.024_bib113) 2012; 6 Wang (10.1016/j.apsb.2021.03.024_bib15) 2018; 43 Lv (10.1016/j.apsb.2021.03.024_bib35) 2019; 10 Cowen (10.1016/j.apsb.2021.03.024_bib123) 2017; 18 Zhang (10.1016/j.apsb.2021.03.024_bib154) 2018; 39 Chen (10.1016/j.apsb.2021.03.024_bib112) 2017; 18 Szklarczyk (10.1016/j.apsb.2021.03.024_bib86) 2016; 44 Li (10.1016/j.apsb.2021.03.024_bib40) 2019; 9 Brunner (10.1016/j.apsb.2021.03.024_bib84) 2004; 48 Wu (10.1016/j.apsb.2021.03.024_bib157) 2015; 20 Yang (10.1016/j.apsb.2021.03.024_bib55) 2019; 24 Yao (10.1016/j.apsb.2021.03.024_bib57) 2018; 1538 Liu (10.1016/j.apsb.2021.03.024_bib141) 2017; 9 Zhao (10.1016/j.apsb.2021.03.024_bib9) 2010; 11 Qu (10.1016/j.apsb.2021.03.024_bib81) 2018; 155 Carmichael (10.1016/j.apsb.2021.03.024_bib69) 2003; 25 Zhang (10.1016/j.apsb.2021.03.024_bib147) 2011; 56 Guo (10.1016/j.apsb.2021.03.024_bib155) 2019; 10 Gutteridge (10.1016/j.apsb.2021.03.024_bib26) 2004; 567 Newman (10.1016/j.apsb.2021.03.024_bib4) 2000; 17 Zhao (10.1016/j.apsb.2021.03.024_bib64) 2020; 165 Licata (10.1016/j.apsb.2021.03.024_bib115) 2012; 40 Qi (10.1016/j.apsb.2021.03.024_bib105) 2019; 25 Kaisar (10.1016/j.apsb.2021.03.024_bib75) 2017; 12 Plewczynski (10.1016/j.apsb.2021.03.024_bib101) 2011; 32 Cheng (10.1016/j.apsb.2021.03.024_bib8) 2017; 167 Derendorf (10.1016/j.apsb.2021.03.024_bib132) 1999; 16 Tyanova (10.1016/j.apsb.2021.03.024_bib90) 2016; 11 Liu (10.1016/j.apsb.2021.03.024_bib63) 2017; 98 Gashaw (10.1016/j.apsb.2021.03.024_bib21) 2011; 16 Zhang (10.1016/j.apsb.2021.03.024_bib25) 2017; 12 Liu (10.1016/j.apsb.2021.03.024_bib43) 2020; 846 LeCluyse (10.1016/j.apsb.2021.03.024_bib73) 2001; 13 Kerrien (10.1016/j.apsb.2021.03.024_bib119) 2012; 40 Rappaport (10.1016/j.apsb.2021.03.024_bib109) 2017; 45 Liu (10.1016/j.apsb.2021.03.024_bib52) 2016; 6 Szklarczyk (10.1016/j.apsb.2021.03.024_bib111) 2019; 47 Williams (10.1016/j.apsb.2021.03.024_bib5) 1975; 56 Kuentz (10.1016/j.apsb.2021.03.024_bib65) 2006; 27 Wang (10.1016/j.apsb.2021.03.024_bib145) 2013; 36 Sung (10.1016/j.apsb.2021.03.024_bib131) 2010; 10 Keshava Prasad (10.1016/j.apsb.2021.03.024_bib116) 2009; 37 Li (10.1016/j.apsb.2021.03.024_bib143) 2018; 44 Shannon (10.1016/j.apsb.2021.03.024_bib124) 2003; 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371 Serrano-Rodríguez (10.1016/j.apsb.2021.03.024_bib71) 2019; 46 Roblek (10.1016/j.apsb.2021.03.024_bib102) 2015; 71 Amberger (10.1016/j.apsb.2021.03.024_bib108) 2017; 58 |
| References_xml | – volume: 96 start-page: 103589 year: 2020 ident: bib67 article-title: Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer's disease publication-title: Bioorg Chem contributor: fullname: Jadhav – volume: 32 start-page: D449 year: 2004 end-page: D451 ident: bib117 article-title: The database of interacting proteins: 2004 update publication-title: Nucleic Acids Res contributor: fullname: Eisenberg – volume: 25 start-page: 671 year: 2003 end-page: 681 ident: bib69 article-title: Population pharmacokinetics of hydroxychloroquine in patients with rheumatoid arthritis publication-title: Ther Drug Monit contributor: fullname: Tett – volume: 32 start-page: 576 year: 2016 end-page: 590 ident: bib22 article-title: Dissection of transporter function: from genetics to structure publication-title: Trends Genet contributor: fullname: Diallinas – volume: 25 start-page: 25 year: 2000 end-page: 29 ident: bib95 article-title: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium publication-title: Nat Genet contributor: fullname: Cherry – volume: 19 start-page: 87 year: 2002 end-page: 91 ident: bib134 article-title: Modeling the pharmacokinetics and pharmacodynamics of a unique oral hypoglycemic agent using neural networks publication-title: Pharm Res contributor: fullname: Hussain – volume: 48 start-page: D545 year: 2020 end-page: D553 ident: bib98 article-title: GMrepo: a database of curated and consistently annotated human gut metagenomes publication-title: Nucleic Acids Res contributor: fullname: Lai – volume: 4 start-page: 44 year: 2009 end-page: 57 ident: bib94 article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources publication-title: Nat Protoc contributor: fullname: Lempicki – volume: 893 start-page: 65 year: 2015 end-page: 76 ident: bib59 article-title: A green protocol for efficient discovery of novel natural compounds: characterization of new ginsenosides from the stems and leaves of publication-title: Anal Chim Acta contributor: fullname: Liu – volume: 32 start-page: 742 year: 2011 end-page: 755 ident: bib101 article-title: Can we trust docking results? Evaluation of seven commonly used programs on PDBbind database publication-title: J Comput Chem contributor: fullname: Ginalski – volume: 9 start-page: 552 year: 2015 end-page: 562 ident: bib17 article-title: Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula publication-title: ISME J contributor: fullname: Zhang – volume: 11 start-page: 2301 year: 2016 end-page: 2319 ident: bib90 article-title: The MaxQuant computational platform for mass spectrometry-based shotgun proteomics publication-title: Nat Protoc contributor: fullname: Cox – volume: 6 start-page: 92 year: 2012 ident: bib113 article-title: HINT: high-quality protein interactomes and their applications in understanding human disease publication-title: BMC Syst Biol contributor: fullname: Yu – volume: 44 start-page: D1045 year: 2016 end-page: D1053 ident: bib88 article-title: BindingDB in 2015: a public database for medicinal chemistry, computational chemistry and systems pharmacology publication-title: Nucleic Acids Res contributor: fullname: Chong – volume: 9 start-page: 10133 year: 2019 ident: bib126 article-title: Centrality in complex networks with overlapping community structure publication-title: Sci Rep contributor: fullname: Hassouni – volume: 117 start-page: 93 year: 2017 end-page: 107 ident: bib32 article-title: Can probiotics modulate human disease by impacting intestinal barrier function?. publication-title: Br J Nutr contributor: fullname: MacDonald – volume: 27 start-page: 91 year: 2006 end-page: 99 ident: bib65 article-title: A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study publication-title: Eur J Pharmaceut Sci contributor: fullname: Röthlisberger – volume: 21 start-page: 827 year: 2005 end-page: 828 ident: bib118 article-title: PDZBase: a protein–protein interaction database for PDZ-domains publication-title: Bioinformatics contributor: fullname: Weinstein – volume: 371 start-page: 2239 year: 2014 end-page: 2241 ident: bib7 article-title: Oral arsenic and retinoic acid for non-high-risk acute promyelocytic leukemia publication-title: N Engl J Med contributor: fullname: Huang – volume: 48 start-page: D845 year: 2020 end-page: D855 ident: bib110 article-title: The DisGeNET knowledge platform for disease genomics: 2019 update publication-title: Nucleic Acids Res contributor: fullname: Sanz – volume: 10 start-page: 1523 year: 2019 ident: bib125 article-title: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets publication-title: Nat Commun contributor: fullname: Tanaseichuk – volume: 155 start-page: 41 year: 2018 end-page: 53 ident: bib81 article-title: A nephron model for study of drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity publication-title: Biomaterials contributor: fullname: Zhao – volume: 232 start-page: 183 year: 2002 end-page: 192 ident: bib72 article-title: Simulated intestinal fluid as transport medium in the Caco-2 cell culture model publication-title: Int J Pharm contributor: fullname: Augustijns – volume: 45 start-page: D877 year: 2017 end-page: D887 ident: bib109 article-title: MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search publication-title: Nucleic Acids Res contributor: fullname: Levitt – volume: 18 start-page: 551 year: 2017 end-page: 562 ident: bib123 article-title: Network propagation: a universal amplifier of genetic associations publication-title: Nat Rev Genet contributor: fullname: Sharan – volume: 31 start-page: 3167 year: 2010 end-page: 3174 ident: bib80 article-title: Hepatotoxicity assay using human hepatocytes trapped in microholes of a microfluidic device publication-title: Electrophoresis contributor: fullname: Park – volume: 58 start-page: 1 year: 2017 ident: bib108 article-title: Searching Online Mendelian Inheritance in Man (OMIM): a knowledgebase of human genes and genetic phenotypes publication-title: Curr Protoc Bioinformatics contributor: fullname: Hamosh – volume: 98 start-page: 786 year: 2017 end-page: 792 ident: bib63 article-title: Structural analysis of a homogeneous polysaccharide from publication-title: Int J Biol Macromol contributor: fullname: Zhao – volume: 2 start-page: 30 year: 2010 ident: bib1 article-title: Herbal therapy: a new pathway for the treatment of Alzheimer's disease publication-title: Alzheimer's Res Ther contributor: fullname: Wang – volume: 56 start-page: 71 year: 1975 end-page: 78 ident: bib5 article-title: The effect of chronic digitoxin administration on the contractile state of normal and nonfailing hypertrophied myocardium publication-title: J Clin Invest contributor: fullname: Potter – volume: 47 start-page: D976 year: 2019 end-page: D982 ident: bib50 article-title: ETCM: an encyclopaedia of traditional Chinese medicine publication-title: Nucleic Acids Res contributor: fullname: Tang – volume: 44 start-page: 212 year: 2018 end-page: 219 ident: bib143 article-title: Identification of quality markers of Yuanhu Zhitong tablets based on integrative pharmacology and data mining publication-title: Phytomedicine contributor: fullname: Liu – volume: 16 start-page: 1037 year: 2011 end-page: 1043 ident: bib21 article-title: What makes a good drug target?. publication-title: Drug Discov Today contributor: fullname: Asadullah – volume: 935 start-page: 1 year: 2013 end-page: 9 ident: bib148 article-title: Identification of the absorbed constituents after oral administration of Yuanhu Zhitong prescription extract and its pharmacokinetic study by rapid resolution liquid chromatography/quadrupole time-of-flight publication-title: J Chromatogr B contributor: fullname: Wang – volume: 39 start-page: 975 year: 2018 end-page: 987 ident: bib154 article-title: Main active constituent identification in Guanxinjing capsule, a traditional Chinese medicine, for the treatment of coronary heart disease complicated with depression publication-title: Acta Pharmacol Sin contributor: fullname: Wang – volume: 67 start-page: 5289 year: 2019 end-page: 5302 ident: bib60 article-title: Untargeted and targeted fingerprinting of extra virgin olive oil volatiles by comprehensive two-dimensional gas chromatography with mass spectrometry: challenges in long-term studies publication-title: J Agric Food Chem contributor: fullname: Cordero – volume: 85 start-page: 1684 year: 2013 end-page: 1699 ident: bib129 article-title: PK/PD assessment in CNS drug discovery: prediction of CSF concentration in rodents for P-glycoprotein substrates and application to publication-title: Biochem Pharmacol contributor: fullname: Lavé – volume: 36 start-page: 1578 year: 2008 end-page: 1586 ident: bib46 article-title: Plasma and urinary tanshinol from publication-title: Drug Metab Dispos contributor: fullname: Sun – volume: 62 start-page: 146 year: 2013 end-page: 158 ident: bib36 article-title: A metagenomic insight into our gut's microbiome publication-title: Gut contributor: fullname: Raes – volume: 10 start-page: 49 year: 2019 ident: bib155 article-title: Prediction of drug positioning for Quan-Du-Zhong Capsules against hypertensive nephropathy based on the robustness of disease network publication-title: Front Pharmacol contributor: fullname: Yang – volume: 12 start-page: 233 year: 2016 end-page: 245 ident: bib151 article-title: Identification of key active constituents of Buchang Naoxintong capsules with therapeutic effects against ischemic stroke by using an integrative pharmacology-based approach publication-title: Mol Biosyst contributor: fullname: Zhang – volume: 166 start-page: 52 year: 2019 end-page: 65 ident: bib37 article-title: Study on the herb–herb interaction of Danqi Tongmai Tablet based on the pharmacokinetics of twelve notoginsenoides in acute myocardial ischemia and sham rats publication-title: J Pharmaceut Biomed Anal contributor: fullname: Zhang – volume: 13 start-page: 558 year: 2012 end-page: 576 ident: bib28 article-title: Pharmacokinetics–pharmacology disconnection of herbal medicines and its potential solutions with cellular pharmacokinetic-pharmacodynamic strategy publication-title: Curr Drug Metabol contributor: fullname: Zha – volume: 12 start-page: 1456 year: 2015 end-page: 1466 ident: bib68 article-title: Predicting the extent of metabolism using publication-title: Mol Pharm contributor: fullname: Benet – volume: 2013 start-page: 658531 year: 2013 ident: bib150 article-title: A computational drug–target network for yuanhu zhitong prescription publication-title: Evid Based Complement Alternat Med contributor: fullname: Yuan – volume: 46 start-page: 226 year: 2019 end-page: 235 ident: bib71 article-title: Comparative pharmacokinetics and a clinical laboratory evaluation of intravenous acetaminophen in Beagle and Galgo Español dogs publication-title: Vet Anaesth Analg contributor: fullname: Serrano-Caballero – volume: 22 start-page: bbaa082 year: 2021 ident: bib99 article-title: gutMEGA: a database of the human gut MEtaGenome Atlas publication-title: Brief Bioinform contributor: fullname: Zhao – volume: 32 start-page: 760 year: 2014 end-page: 772 ident: bib78 article-title: Microfluidic organs-on-chips publication-title: Nat Biotechnol contributor: fullname: Ingber – volume: 2104 start-page: 337 year: 2020 end-page: 360 ident: bib89 article-title: Using MetaboAnalyst 4.0 for metabolomics data analysis, interpretation, and integration with other omics data publication-title: Methods Mol Biol contributor: fullname: Xia – volume: 37 start-page: W623 year: 2009 end-page: W633 ident: bib49 article-title: PubChem: a public information system for analyzing bioactivities of small molecules publication-title: Nucleic Acids Res contributor: fullname: Bryant – volume: 13 start-page: 2498 year: 2003 end-page: 2504 ident: bib124 article-title: Cytoscape: a software environment for integrated models of biomolecular interaction networks publication-title: Genome Res contributor: fullname: Ramage – volume: 68 start-page: 890 year: 2016 end-page: 903 ident: bib24 article-title: Receptor–ligand interactions: advanced biomedical applications publication-title: Mater Sci Eng C Mater Biol Appl contributor: fullname: Tennikova – volume: 12 start-page: 89 year: 2017 end-page: 103 ident: bib75 article-title: New experimental models of the blood–brain barrier for CNS drug discovery publication-title: Expert Opin Drug Discov contributor: fullname: Cucullo – volume: 123 start-page: 766 year: 2019 end-page: 774 ident: bib62 article-title: Multi-fingerprint profiling combined with chemometric methods for investigating the quality of publication-title: Int J Biol Macromol contributor: fullname: Rui – volume: 47 start-page: D506 year: 2019 end-page: D515 ident: bib91 article-title: UniProt: a worldwide hub of protein knowledge publication-title: Nucleic Acids Res – volume: 234 start-page: 68 year: 2019 end-page: 75 ident: bib61 article-title: Screening of active fractions from Curcuma Longa Radix isolated by HPLC and GC–MS for promotion of blood circulation and relief of pain publication-title: J Ethnopharmacol contributor: fullname: Hu – volume: 13 start-page: 255 year: 2019 end-page: 264 ident: bib70 article-title: Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles publication-title: Drug Des Dev Ther contributor: fullname: Tian – volume: 55 start-page: 1233 year: 2003 end-page: 1251 ident: bib135 article-title: Clinical application of artificial neural network (ANN) modeling to predict pharmacokinetic parameters of severely ill patients publication-title: Adv Drug Deliv Rev contributor: fullname: Yamamura – volume: 18 start-page: 182 year: 2017 ident: bib112 article-title: HAPPI-2: a comprehensive and high-quality map of human annotated and predicted protein interactions publication-title: BMC Genom contributor: fullname: Nguyen – volume: 12 start-page: 835 year: 2011 end-page: 849 ident: bib18 article-title: Herb–drug interactions involving drug metabolizing enzymes and transporters publication-title: Curr Drug Metabol contributor: fullname: Li – volume: 21 start-page: 2076 year: 2005 end-page: 2082 ident: bib114 article-title: Online predicted human interaction database publication-title: Bioinformatics contributor: fullname: Jurisica – volume: 87 start-page: 1123 year: 2010 end-page: 1124 ident: bib48 article-title: ChemSpider: an online chemical information resource publication-title: J Chem Educ contributor: fullname: Williams – volume: 165 start-page: 2475 year: 2020 end-page: 2483 ident: bib64 article-title: Chemical characteristic and bioactivity of hemicellulose-based polysaccharides isolated from publication-title: Int J Biol Macromol contributor: fullname: Dong – volume: 15 start-page: 858 year: 2015 end-page: 871 ident: bib77 article-title: Evaluating potential P-gp substrates: main aspects to choose the adequate permeability model for assessing gastrointestinal drug absorption publication-title: Mini Rev Med Chem contributor: fullname: dos Reis Serra – volume: 1297 start-page: 168 year: 2013 end-page: 178 ident: bib38 article-title: Analysis of herb–herb interaction when decocting together by using ultra-high-performance liquid chromatography–tandem mass spectrometry and fuzzy chemical identification strategy with poly-proportion design publication-title: J Chromatogr A contributor: fullname: Qian – volume: 99 year: 2020 ident: bib153 article-title: Clinical study on post evaluation after listing of Qizhi Weitong granules: study protocol clinical trial (SPIRIT compliant) publication-title: Medicine (Baltim) contributor: fullname: Wang – volume: 9 start-page: 3 year: 2017 end-page: 13 ident: bib141 article-title: A new concept on quality marker for quality assessment and process control of Chinese medicines publication-title: Chin Herb Med contributor: fullname: Hou – volume: 567 start-page: 67 year: 2004 end-page: 73 ident: bib26 article-title: Conformational change in substrate binding, catalysis and product release: an open and shut case?. publication-title: FEBS Lett contributor: fullname: Thornton – volume: 13 start-page: 343 year: 2001 end-page: 368 ident: bib73 article-title: Human hepatocyte culture systems for the publication-title: Eur J Pharmaceut Sci contributor: fullname: LeCluyse – volume: 173 start-page: 283 year: 2018 end-page: 285 ident: bib92 article-title: The Cancer Genome Atlas: creating lasting value beyond its data publication-title: Cell contributor: fullname: Zenklusen – volume: 32 start-page: 2167 year: 2016 end-page: 2175 ident: bib121 article-title: Characterizing gene sets using discriminative random walks with restart on heterogeneous biological networks publication-title: Bioinformatics contributor: fullname: Sinha – volume: 6 start-page: 568 year: 2016 end-page: 575 ident: bib53 article-title: Identification and differentiation of publication-title: Acta Pharm Sin B contributor: fullname: Guo – volume: 34 start-page: D668 year: 2006 end-page: D672 ident: bib85 article-title: DrugBank: a comprehensive resource for publication-title: Nucleic Acids Res contributor: fullname: Stothard – volume: 36 start-page: 3874 year: 2013 end-page: 3882 ident: bib145 article-title: Rapid identification and comparative analysis of the chemical constituents and metabolites of publication-title: J Separ Sci contributor: fullname: Shi – volume: 17 start-page: 215 year: 2000 end-page: 234 ident: bib4 article-title: The influence of natural products upon drug discovery publication-title: Nat Prod Rep contributor: fullname: Snader – volume: 9 start-page: 1113 year: 2019 end-page: 1144 ident: bib40 article-title: Current trends in drug metabolism and pharmacokinetics publication-title: Acta Pharm Sin B contributor: fullname: Tang – volume: 12 year: 2019 ident: bib136 article-title: Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns publication-title: Dis Model Mech contributor: fullname: Vogel – volume: 38 start-page: 2746 year: 2015 end-page: 2752 ident: bib138 article-title: Development of immunoaffinity chromatography to specifically knockout baicalin from Gegenqinlian Decoction publication-title: J Separ Sci contributor: fullname: Zhao – volume: 156 start-page: 141 year: 2000 ident: bib6 article-title: Thiericke drug discovery from nature 1999 springer verlag cambridge publication-title: J Plant Physiol contributor: fullname: Grabley – volume: 1427 start-page: 96 year: 2016 end-page: 101 ident: bib58 article-title: Optimisation and establishment of separation conditions of organic acids from publication-title: J Chromatogr A contributor: fullname: Wang – volume: 38 start-page: 1141 year: 2017 end-page: 1149 ident: bib47 article-title: A new method to evaluate the dose–effect relationship of a TCM formula Gegen Qinlian Decoction: "Focus" mode of integrated biomarkers publication-title: Acta Pharmacol Sin contributor: fullname: Bai – volume: 11 start-page: 417 year: 2010 end-page: 430 ident: bib9 article-title: Molecular networks for the study of TCM pharmacology publication-title: Brief Bioinform contributor: fullname: Zhang – volume: 1538 start-page: 34 year: 2018 end-page: 44 ident: bib57 article-title: Global profiling combined with predicted metabolites screening for discovery of natural compounds: characterization of ginsenosides in the leaves of publication-title: J Chromatogr A contributor: fullname: Hou – volume: 45 start-page: 1279 year: 2020 end-page: 1286 ident: bib137 article-title: Research progress on identification of pharmacodynamic substance basis of traditional Chinese medicine based on target constituent knock-out/knock-in technology publication-title: China J Chin Mater Med contributor: fullname: Qin – volume: 44 start-page: 117 year: 2018 end-page: 128 ident: bib144 article-title: Identifying potential quality markers of Xin-Su-Ning capsules acting on arrhythmia by integrating UHPLC–LTQ-Orbitrap, ADME prediction and network target analysis publication-title: Phytomedicine contributor: fullname: Zhang – volume: 25 start-page: 577 year: 2020 ident: bib56 article-title: Phytochemistry and comprehensive chemical profiling study of flavonoids and phenolic acids in the aerial parts of publication-title: Molecules contributor: fullname: Zhang – volume: 12 start-page: 17 year: 2017 end-page: 37 ident: bib25 article-title: High performance enzyme kinetics of turnover, activation and inhibition for translational drug discovery publication-title: Expet Opin Drug Discov contributor: fullname: Wong – volume: 16 start-page: 176 year: 1999 end-page: 185 ident: bib132 article-title: Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives publication-title: Pharm Res contributor: fullname: Meibohm – volume: 118 start-page: 109252 year: 2019 ident: bib31 article-title: The interaction between the gut microbiota and herbal medicines publication-title: Biomed Pharmacother contributor: fullname: Zhang – volume: 216 start-page: 107698 year: 2020 ident: bib16 article-title: Current state and future perspective of cardiovascular medicines derived from natural products publication-title: Pharmacol Ther contributor: fullname: Zhao – volume: 39 start-page: 357 year: 2014 end-page: 362 ident: bib14 article-title: Integrative pharmacology: new paradigm of modernization of Chinese medicine publication-title: China J Chin Mater Med contributor: fullname: Yang – volume: 12 start-page: 2165 year: 2012 end-page: 2174 ident: bib79 article-title: Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow publication-title: Lab Chip contributor: fullname: Ingber – volume: 59 start-page: 3973 year: 2015 end-page: 3983 ident: bib128 article-title: Optimization of polyene-azole combination therapy against aspergillosis using an publication-title: Antimicrob Agents Chemother contributor: fullname: Meletiadis – volume: 21 start-page: 204 year: 2016 end-page: 207 ident: bib2 article-title: An analysis of FDA-approved drugs: natural products and their derivatives publication-title: Drug Discov Today contributor: fullname: Hoyer – volume: 16 start-page: 414 year: 2012 end-page: 421 ident: bib13 article-title: Future perspectives of Chinese medical formulae: chinmedomics as an effector publication-title: Omics contributor: fullname: Sun – volume: 38 start-page: 1987 year: 2019 end-page: 1998 ident: bib34 article-title: Connection between gut microbiome and the development of obesity publication-title: Eur J Clin Microbiol Infect Dis contributor: fullname: Guo – volume: 120 start-page: 960 year: 2018 end-page: 968 ident: bib133 article-title: Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine publication-title: Br J Anaesth contributor: fullname: Kwok – volume: 10 start-page: 2441 year: 2014 end-page: 2447 ident: bib96 article-title: KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway analysis using a path analysis model publication-title: Mol Biosyst contributor: fullname: Chen – volume: 15 start-page: 1005 year: 2019 end-page: 1019 ident: bib130 article-title: Pharmacokinetic and pharmacodynamic insights from microfluidic intestine-on-a-chip models publication-title: Expert Opin Drug Metab Toxicol contributor: fullname: Sung – volume: 26 start-page: 252 year: 2019 end-page: 264 ident: bib104 article-title: Obese individuals with and without type 2 diabetes show different gut microbial functional capacity and composition publication-title: Cell Host Microbe contributor: fullname: Boehm – volume: 53 start-page: 53 year: 2019 end-page: 61 ident: bib149 article-title: Poly-pharmacokinetic strategy-delineated metabolic fate of bioactive compounds in a traditional Chinese medicine formula, Yuanhu Zhitong tablets, using parallel reaction monitoring mode publication-title: Phytomedicine contributor: fullname: Zhang – volume: 167 start-page: W21 year: 2017 end-page: W34 ident: bib8 article-title: CONSORT extension for Chinese herbal medicine formulas 2017: recommendations, explanation, and elaboration (simplified Chinese version) publication-title: Ann Intern Med contributor: fullname: Moher – volume: 51 start-page: 1132 year: 2011 end-page: 1151 ident: bib12 article-title: Fangjiomics: in search of effective and safe combination therapies publication-title: J Clin Pharmacol contributor: fullname: Wang – volume: 28 start-page: 691 year: 2011 end-page: 693 ident: bib27 article-title: Nucleic acid drug delivery and targeting publication-title: Pharm Res contributor: fullname: Takakura – volume: 43 start-page: 559 year: 2008 end-page: 564 ident: bib76 article-title: Advances in the MDCK-MDR1 cell model and its applications to screen drug permeability publication-title: Acta Pharm Sin contributor: fullname: Zeng – volume: 56 start-page: 497 year: 2011 end-page: 504 ident: bib147 article-title: Simultaneous quantification of 17 constituents from Yuanhu Zhitong tablet using rapid resolution liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry publication-title: J Pharmaceut Biomed contributor: fullname: Meng – volume: 142 start-page: 176 year: 2019 end-page: 191 ident: bib30 article-title: Gut microbiota, a new frontier to understand traditional Chinese medicines publication-title: Pharmacol Res contributor: fullname: Yan – volume: 12 start-page: 48 year: 2018 ident: bib74 article-title: Study on the interaction between active components from traditional Chinese medicine and plasma proteins publication-title: Chem Cent J contributor: fullname: Liu – volume: 10 start-page: 415 year: 2019 ident: bib35 article-title: Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment publication-title: Cell Death Dis contributor: fullname: Guo – volume: 107 start-page: 1082 year: 2020 end-page: 1115 ident: bib41 article-title: Physiologically-based pharmacokinetic models for evaluating membrane transporter mediated drug–drug interactions: current capabilities, case studies, future opportunities, and recommendations publication-title: Clin Pharmacol Ther contributor: fullname: Zheng – volume: 13 start-page: 1763 year: 2016 end-page: 1778 ident: bib66 article-title: modeling of gastrointestinal drug absorption: predictive performance of three physiologically based absorption models publication-title: Mol Pharm contributor: fullname: Tannergren – volume: 46 start-page: D649 year: 2018 end-page: D655 ident: bib97 article-title: The reactome pathway knowledgebase publication-title: Nucleic Acids Res contributor: fullname: Garapati – volume: 37 start-page: D767 year: 2009 end-page: D772 ident: bib116 article-title: Human protein reference database—2009 update publication-title: Nucleic Acids Res contributor: fullname: Mathivanan – volume: 21 start-page: 287 year: 2020 ident: bib152 article-title: Tongmai Yangxin intervening in myocardial remodeling after PCI for coronary heart disease: study protocol for a double-blind, randomized controlled trial publication-title: Trials contributor: fullname: Hu – volume: 17 start-page: 1217 year: 2011 end-page: 1220 ident: bib3 article-title: The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine publication-title: Nat Med contributor: fullname: Tu – volume: 7 start-page: 439 year: 2017 end-page: 446 ident: bib45 article-title: Approaches to establish Q-markers for the quality standards of traditional Chinese medicines publication-title: Acta Pharm Sin B contributor: fullname: Liu – volume: 33 start-page: 681 year: 2016 end-page: 708 ident: bib103 article-title: Chemical proteomics approaches for identifying the cellular targets of natural products publication-title: Nat Prod Rep contributor: fullname: Sieber – volume: 19 start-page: 4182 year: 2013 end-page: 4190 ident: bib23 article-title: The role of protonation states in ligand–receptor recognition and binding publication-title: Curr Pharmaceut Des contributor: fullname: Alexov – volume: 30 start-page: 523 year: 2014 end-page: 530 ident: bib122 article-title: Causal analysis approaches in ingenuity pathway analysis publication-title: Bioinformatics contributor: fullname: Tugendreich – volume: 21 start-page: 403 year: 2020 end-page: 426 ident: bib106 article-title: 2020 FDA drug–drug interaction guidance: a comparison analysis and action plan by pharmaceutical industrial scientists publication-title: Curr Drug Metabol contributor: fullname: Lu – volume: 10 start-page: 1646 year: 2020 end-page: 1657 ident: bib39 article-title: Transporters (OATs and OATPs) contribute to illustrate the mechanism of medicinal compatibility of ingredients with different properties in yuanhuzhitong prescription publication-title: Acta Pharm Sin B contributor: fullname: Cui – volume: 20 start-page: 389 year: 2019 end-page: 403 ident: bib44 article-title: Deep learning: new computational modelling techniques for genomics publication-title: Nat Rev Genet contributor: fullname: Theis – volume: 25 start-page: 9 year: 2019 end-page: 16 ident: bib142 article-title: Discovery and application of quality marker of traditional Chinese medicine based on integrative pharmacology publication-title: Chin J Exp Tradit Med Form contributor: fullname: Guo – volume: 43 start-page: 1297 year: 2018 end-page: 1302 ident: bib15 article-title: Modern research progress of traditional Chinese medicine based on integrative pharmacology publication-title: China J Chin Mater Med contributor: fullname: Xu – volume: 20 start-page: 1912 year: 2019 ident: bib33 article-title: Curcumin and intestinal inflammatory diseases: molecular mechanisms of protection publication-title: Int J Mol Sci contributor: fullname: Chaaban – volume: 10 start-page: 446 year: 2010 end-page: 455 ident: bib131 article-title: A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip publication-title: Lab Chip contributor: fullname: Shuler – volume: 846 start-page: 1 year: 2020 end-page: 66 ident: bib43 article-title: Computational network biology: data, models, and applications publication-title: Phys Rep contributor: fullname: Cheng – volume: 20 start-page: 10047 year: 2015 end-page: 10064 ident: bib157 article-title: A publication-title: Molecules contributor: fullname: Zhao – volume: 40 start-page: D841 year: 2012 end-page: D846 ident: bib119 article-title: The IntAct molecular interaction database in 2012 publication-title: Nucleic Acids Res contributor: fullname: Chen – volume: 28 start-page: 416 year: 2016 end-page: 423 ident: bib93 article-title: International cancer genome Consortium (ICGC) publication-title: Med Genet-Berlin contributor: fullname: Sauter – volume: 29 year: 2019 ident: bib127 article-title: Centrality-based identification of important edges in complex networks publication-title: Chaos contributor: fullname: Lehnertz – volume: 236 start-page: 277 year: 2019 end-page: 287 ident: bib20 article-title: TCM-ADMEpred: a novel strategy for poly-pharmacokinetics prediction of traditional Chinese medicine based on single constituent pharmacokinetics, structural similarity, and mathematical modeling publication-title: J Ethnopharmacol contributor: fullname: Xu – volume: 6 start-page: 1941 year: 2012 end-page: 1947 ident: bib146 article-title: Study on the application of intestinal absorption publication-title: J Med Plants Res contributor: fullname: D S – volume: 11 start-page: 110 year: 2013 end-page: 120 ident: bib10 article-title: Traditional Chinese medicine network pharmacology: theory, methodology and application publication-title: Chin J Nat Med contributor: fullname: Zhang – volume: 328 start-page: 1662 year: 2010 end-page: 1668 ident: bib83 article-title: Reconstituting organ-level lung functions on a chip publication-title: Science contributor: fullname: Ingber – volume: 25 start-page: 1225 year: 2019 end-page: 1233 ident: bib105 article-title: Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome publication-title: Nat Med contributor: fullname: Wang – volume: 31 start-page: 21 year: 2017 end-page: 24 ident: bib156 article-title: Study on analgesic effect and dose–effect relationship of Yuanhuzhitong prescrption on mice model of pain publication-title: Res Pract Chin Med contributor: fullname: Li – volume: 47 start-page: D930 year: 2019 end-page: D940 ident: bib51 article-title: ChEMBL: towards direct deposition of bioassay data publication-title: Nucleic Acids Res contributor: fullname: Félix – volume: 48 start-page: 3850 year: 2004 end-page: 3857 ident: bib84 article-title: [ publication-title: Antimicrob Agents Chemother contributor: fullname: Mitterhauser – volume: 24 start-page: 4098 year: 2019 ident: bib55 article-title: Rapid Analysis of the chemical compositions in publication-title: Molecules contributor: fullname: He – volume: 40 start-page: D857 year: 2012 end-page: D861 ident: bib115 article-title: MINT, the molecular interaction database: 2012 update publication-title: Nucleic Acids Res contributor: fullname: Galeota – volume: 76 start-page: 473 year: 2019 end-page: 493 ident: bib29 article-title: An insight into gut microbiota and its functionalities publication-title: Cell Mol Life Sci contributor: fullname: Khan – volume: 47 start-page: 1443 year: 2016 end-page: 1457 ident: bib140 article-title: A new concept on quality marker of Chinese materia medica: quality control for Chinese medicinal products publication-title: Chin Tradit Herb Drugs contributor: fullname: Liao – volume: 44 start-page: D380 year: 2016 end-page: D384 ident: bib86 article-title: Stitch 5: augmenting protein–chemical interaction networks with tissue and affinity data publication-title: Nucleic Acids Res contributor: fullname: Kuhn – volume: 9 start-page: 1563 year: 2016 end-page: 1566 ident: bib139 article-title: Application of ingredient knock-out technology in pharmacodynamic material basis research of traditional Chinese medicine publication-title: Moder Tradit Chin Med Mater Med World Sci Technol contributor: fullname: Center – volume: 47 start-page: D607 year: 2019 end-page: D613 ident: bib111 article-title: STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets publication-title: Nucleic Acids Res contributor: fullname: Huerta-Cepas – volume: 47 start-page: D1018 year: 2019 end-page: D1027 ident: bib107 article-title: Expansion of the human phenotype ontology (HPO) knowledge base and resources publication-title: Nucleic Acids Res contributor: fullname: Gourdine – volume: 71 start-page: 131 year: 2015 end-page: 142 ident: bib102 article-title: Drug–drug interaction software in clinical practice: a systematic review publication-title: Eur J Clin Pharmacol contributor: fullname: Lainscak – volume: 9 start-page: 15889 year: 2019 ident: bib42 article-title: A new strategy for identifying mechanisms of drug–drug interaction using transcriptome analysis: compound kushen injection as a proof of principle publication-title: Sci Rep contributor: fullname: Wang – volume: 13 start-page: 3599 year: 2013 end-page: 3608 ident: bib82 article-title: Microfluidic heart on a chip for higher throughput pharmacological studies publication-title: Lab Chip contributor: fullname: Parker – volume: 25 start-page: 1442 year: 2019 end-page: 1452 ident: bib100 article-title: A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research publication-title: Nat Med contributor: fullname: Kearney – volume: 6 start-page: 13 year: 2014 ident: bib11 article-title: TCMSP: a database of systems pharmacology for drug discovery from herbal medicines publication-title: J Cheminf contributor: fullname: Huang – volume: 4 start-page: 759 year: 2008 end-page: 770 ident: bib19 article-title: Structure–ADME relationship: still a long way to go?. publication-title: Expert Opin Drug Met contributor: fullname: Wang – volume: 6 start-page: 21146 year: 2016 ident: bib52 article-title: BATMAN-TCM: a bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine publication-title: Sci Rep contributor: fullname: Li – volume: 48 start-page: D1031 year: 2020 end-page: D1041 ident: bib87 article-title: Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics publication-title: Nucleic Acids Res contributor: fullname: Wang – volume: 1599 start-page: 125 year: 2019 end-page: 135 ident: bib54 article-title: Integrated liquid chromatography–mass spectrometry and nuclear magnetic resonance spectra for the comprehensive characterization of various components in the Shuxuening injection publication-title: J Chromatogr A contributor: fullname: Li – volume: 7 start-page: 488 year: 2006 ident: bib120 article-title: Evaluation of clustering algorithms for protein–protein interaction networks publication-title: BMC Bioinf contributor: fullname: van Helden – volume: 96 start-page: 103589 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib67 article-title: Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer's disease publication-title: Bioorg Chem doi: 10.1016/j.bioorg.2020.103589 contributor: fullname: Shaikh – volume: 21 start-page: 2076 year: 2005 ident: 10.1016/j.apsb.2021.03.024_bib114 article-title: Online predicted human interaction database publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti273 contributor: fullname: Brown – volume: 45 start-page: 1279 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib137 article-title: Research progress on identification of pharmacodynamic substance basis of traditional Chinese medicine based on target constituent knock-out/knock-in technology publication-title: China J Chin Mater Med contributor: fullname: Cui – volume: 13 start-page: 558 year: 2012 ident: 10.1016/j.apsb.2021.03.024_bib28 article-title: Pharmacokinetics–pharmacology disconnection of herbal medicines and its potential solutions with cellular pharmacokinetic-pharmacodynamic strategy publication-title: Curr Drug Metabol doi: 10.2174/1389200211209050558 contributor: fullname: Zhang – volume: 25 start-page: 9 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib142 article-title: Discovery and application of quality marker of traditional Chinese medicine based on integrative pharmacology publication-title: Chin J Exp Tradit Med Form contributor: fullname: Xu – volume: 44 start-page: 212 year: 2018 ident: 10.1016/j.apsb.2021.03.024_bib143 article-title: Identification of quality markers of Yuanhu Zhitong tablets based on integrative pharmacology and data mining publication-title: Phytomedicine doi: 10.1016/j.phymed.2018.03.002 contributor: fullname: Li – volume: 31 start-page: 3167 year: 2010 ident: 10.1016/j.apsb.2021.03.024_bib80 article-title: Hepatotoxicity assay using human hepatocytes trapped in microholes of a microfluidic device publication-title: Electrophoresis doi: 10.1002/elps.201000122 contributor: fullname: Yeon – volume: 56 start-page: 71 year: 1975 ident: 10.1016/j.apsb.2021.03.024_bib5 article-title: The effect of chronic digitoxin administration on the contractile state of normal and nonfailing hypertrophied myocardium publication-title: J Clin Invest doi: 10.1172/JCI108081 contributor: fullname: Williams – volume: 6 start-page: 13 year: 2014 ident: 10.1016/j.apsb.2021.03.024_bib11 article-title: TCMSP: a database of systems pharmacology for drug discovery from herbal medicines publication-title: J Cheminf doi: 10.1186/1758-2946-6-13 contributor: fullname: Ru – volume: 68 start-page: 890 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib24 article-title: Receptor–ligand interactions: advanced biomedical applications publication-title: Mater Sci Eng C Mater Biol Appl doi: 10.1016/j.msec.2016.07.072 contributor: fullname: Guryanov – volume: 12 start-page: 1456 year: 2015 ident: 10.1016/j.apsb.2021.03.024_bib68 article-title: Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions publication-title: Mol Pharm doi: 10.1021/mp500783g contributor: fullname: Hosey – volume: 9 start-page: 1563 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib139 article-title: Application of ingredient knock-out technology in pharmacodynamic material basis research of traditional Chinese medicine publication-title: Moder Tradit Chin Med Mater Med World Sci Technol contributor: fullname: Xiao – volume: 24 start-page: 4098 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib55 article-title: Rapid Analysis of the chemical compositions in Semiliquidambar cathayensis Roots by ultra high-performance liquid chromatography and quadrupole time-of-flight tandem mass spectrometry publication-title: Molecules doi: 10.3390/molecules24224098 contributor: fullname: Yang – volume: 56 start-page: 497 year: 2011 ident: 10.1016/j.apsb.2021.03.024_bib147 article-title: Simultaneous quantification of 17 constituents from Yuanhu Zhitong tablet using rapid resolution liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry publication-title: J Pharmaceut Biomed doi: 10.1016/j.jpba.2011.06.008 contributor: fullname: Zhang – volume: 13 start-page: 2498 year: 2003 ident: 10.1016/j.apsb.2021.03.024_bib124 article-title: Cytoscape: a software environment for integrated models of biomolecular interaction networks publication-title: Genome Res doi: 10.1101/gr.1239303 contributor: fullname: Shannon – volume: 173 start-page: 283 year: 2018 ident: 10.1016/j.apsb.2021.03.024_bib92 article-title: The Cancer Genome Atlas: creating lasting value beyond its data publication-title: Cell doi: 10.1016/j.cell.2018.03.042 contributor: fullname: Hutter – volume: 34 start-page: D668 year: 2006 ident: 10.1016/j.apsb.2021.03.024_bib85 article-title: DrugBank: a comprehensive resource for in silico drug discovery and exploration publication-title: Nucleic Acids Res doi: 10.1093/nar/gkj067 contributor: fullname: Wishart – volume: 25 start-page: 1225 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib105 article-title: Gut microbiota-bile acid-interleukin-22 axis orchestrates polycystic ovary syndrome publication-title: Nat Med doi: 10.1038/s41591-019-0509-0 contributor: fullname: Qi – volume: 12 start-page: 835 year: 2011 ident: 10.1016/j.apsb.2021.03.024_bib18 article-title: Herb–drug interactions involving drug metabolizing enzymes and transporters publication-title: Curr Drug Metabol doi: 10.2174/138920011797470083 contributor: fullname: Liu – volume: 36 start-page: 3874 year: 2013 ident: 10.1016/j.apsb.2021.03.024_bib145 article-title: Rapid identification and comparative analysis of the chemical constituents and metabolites of Phellodendri amurensis cortex and Zhibai dihuang pill by ultra-performance liquid chromatography with quadrupole TOF-MS publication-title: J Separ Sci doi: 10.1002/jssc.201300794 contributor: fullname: Wang – volume: 43 start-page: 559 year: 2008 ident: 10.1016/j.apsb.2021.03.024_bib76 article-title: Advances in the MDCK-MDR1 cell model and its applications to screen drug permeability publication-title: Acta Pharm Sin contributor: fullname: Liu – volume: 1297 start-page: 168 year: 2013 ident: 10.1016/j.apsb.2021.03.024_bib38 article-title: Analysis of herb–herb interaction when decocting together by using ultra-high-performance liquid chromatography–tandem mass spectrometry and fuzzy chemical identification strategy with poly-proportion design publication-title: J Chromatogr A doi: 10.1016/j.chroma.2013.05.001 contributor: fullname: Shen – volume: 234 start-page: 68 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib61 article-title: Screening of active fractions from Curcuma Longa Radix isolated by HPLC and GC–MS for promotion of blood circulation and relief of pain publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2018.09.035 contributor: fullname: Chen – volume: 32 start-page: 742 year: 2011 ident: 10.1016/j.apsb.2021.03.024_bib101 article-title: Can we trust docking results? Evaluation of seven commonly used programs on PDBbind database publication-title: J Comput Chem doi: 10.1002/jcc.21643 contributor: fullname: Plewczynski – volume: 10 start-page: 1523 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib125 article-title: Metascape provides a biologist-oriented resource for the analysis of systems-level datasets publication-title: Nat Commun doi: 10.1038/s41467-019-09234-6 contributor: fullname: Zhou – volume: 21 start-page: 204 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib2 article-title: An analysis of FDA-approved drugs: natural products and their derivatives publication-title: Drug Discov Today doi: 10.1016/j.drudis.2015.01.009 contributor: fullname: Patridge – volume: 71 start-page: 131 year: 2015 ident: 10.1016/j.apsb.2021.03.024_bib102 article-title: Drug–drug interaction software in clinical practice: a systematic review publication-title: Eur J Clin Pharmacol doi: 10.1007/s00228-014-1786-7 contributor: fullname: Roblek – volume: 44 start-page: 117 year: 2018 ident: 10.1016/j.apsb.2021.03.024_bib144 article-title: Identifying potential quality markers of Xin-Su-Ning capsules acting on arrhythmia by integrating UHPLC–LTQ-Orbitrap, ADME prediction and network target analysis publication-title: Phytomedicine doi: 10.1016/j.phymed.2018.01.019 contributor: fullname: Guo – volume: 10 start-page: 49 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib155 article-title: Prediction of drug positioning for Quan-Du-Zhong Capsules against hypertensive nephropathy based on the robustness of disease network publication-title: Front Pharmacol doi: 10.3389/fphar.2019.00049 contributor: fullname: Guo – volume: 29 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib127 article-title: Centrality-based identification of important edges in complex networks publication-title: Chaos doi: 10.1063/1.5081098 contributor: fullname: Bröhl – volume: 156 start-page: 141 year: 2000 ident: 10.1016/j.apsb.2021.03.024_bib6 article-title: Thiericke drug discovery from nature 1999 springer verlag cambridge publication-title: J Plant Physiol contributor: fullname: Hans – volume: 6 start-page: 92 year: 2012 ident: 10.1016/j.apsb.2021.03.024_bib113 article-title: HINT: high-quality protein interactomes and their applications in understanding human disease publication-title: BMC Syst Biol doi: 10.1186/1752-0509-6-92 contributor: fullname: Das – volume: 1538 start-page: 34 year: 2018 ident: 10.1016/j.apsb.2021.03.024_bib57 article-title: Global profiling combined with predicted metabolites screening for discovery of natural compounds: characterization of ginsenosides in the leaves of Panax notoginseng as a case study publication-title: J Chromatogr A doi: 10.1016/j.chroma.2018.01.040 contributor: fullname: Yao – volume: 935 start-page: 1 year: 2013 ident: 10.1016/j.apsb.2021.03.024_bib148 article-title: Identification of the absorbed constituents after oral administration of Yuanhu Zhitong prescription extract and its pharmacokinetic study by rapid resolution liquid chromatography/quadrupole time-of-flight publication-title: J Chromatogr B doi: 10.1016/j.jchromb.2013.07.015 contributor: fullname: Tao – volume: 16 start-page: 1037 year: 2011 ident: 10.1016/j.apsb.2021.03.024_bib21 article-title: What makes a good drug target?. publication-title: Drug Discov Today doi: 10.1016/j.drudis.2011.09.007 contributor: fullname: Gashaw – volume: 20 start-page: 1912 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib33 article-title: Curcumin and intestinal inflammatory diseases: molecular mechanisms of protection publication-title: Int J Mol Sci doi: 10.3390/ijms20081912 contributor: fullname: Burge – volume: 1427 start-page: 96 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib58 article-title: Optimisation and establishment of separation conditions of organic acids from Usnea longissima Ach. by pH-zone-refining counter-current chromatography: discussion of the eluotropic sequence publication-title: J Chromatogr A doi: 10.1016/j.chroma.2015.12.016 contributor: fullname: Sun – volume: 18 start-page: 182 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib112 article-title: HAPPI-2: a comprehensive and high-quality map of human annotated and predicted protein interactions publication-title: BMC Genom doi: 10.1186/s12864-017-3512-1 contributor: fullname: Chen – volume: 20 start-page: 10047 year: 2015 ident: 10.1016/j.apsb.2021.03.024_bib157 article-title: A 1H-NMR-based metabonomic study on the anti-depressive effect of the total alkaloid of Corydalis Rhizoma publication-title: Molecules doi: 10.3390/molecules200610047 contributor: fullname: Wu – volume: 25 start-page: 577 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib56 article-title: Phytochemistry and comprehensive chemical profiling study of flavonoids and phenolic acids in the aerial parts of Allium Mongolicum Regel and their intestinal motility evaluation publication-title: Molecules doi: 10.3390/molecules25030577 contributor: fullname: Dong – volume: 62 start-page: 146 year: 2013 ident: 10.1016/j.apsb.2021.03.024_bib36 article-title: A metagenomic insight into our gut's microbiome publication-title: Gut doi: 10.1136/gutjnl-2011-301805 contributor: fullname: Lepage – volume: 9 start-page: 3 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib141 article-title: A new concept on quality marker for quality assessment and process control of Chinese medicines publication-title: Chin Herb Med doi: 10.1016/S1674-6384(17)60070-4 contributor: fullname: Liu – volume: 16 start-page: 414 year: 2012 ident: 10.1016/j.apsb.2021.03.024_bib13 article-title: Future perspectives of Chinese medical formulae: chinmedomics as an effector publication-title: Omics doi: 10.1089/omi.2011.0138 contributor: fullname: Wang – volume: 11 start-page: 2301 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib90 article-title: The MaxQuant computational platform for mass spectrometry-based shotgun proteomics publication-title: Nat Protoc doi: 10.1038/nprot.2016.136 contributor: fullname: Tyanova – volume: 4 start-page: 44 year: 2009 ident: 10.1016/j.apsb.2021.03.024_bib94 article-title: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources publication-title: Nat Protoc doi: 10.1038/nprot.2008.211 contributor: fullname: Huang – volume: 45 start-page: D877 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib109 article-title: MalaCards: an amalgamated human disease compendium with diverse clinical and genetic annotation and structured search publication-title: Nucleic Acids Res doi: 10.1093/nar/gkw1012 contributor: fullname: Rappaport – volume: 58 start-page: 1 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib108 article-title: Searching Online Mendelian Inheritance in Man (OMIM): a knowledgebase of human genes and genetic phenotypes publication-title: Curr Protoc Bioinformatics doi: 10.1002/cpbi.27 contributor: fullname: Amberger – volume: 44 start-page: D380 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib86 article-title: Stitch 5: augmenting protein–chemical interaction networks with tissue and affinity data publication-title: Nucleic Acids Res doi: 10.1093/nar/gkv1277 contributor: fullname: Szklarczyk – volume: 2 start-page: 30 year: 2010 ident: 10.1016/j.apsb.2021.03.024_bib1 article-title: Herbal therapy: a new pathway for the treatment of Alzheimer's disease publication-title: Alzheimer's Res Ther doi: 10.1186/alzrt54 contributor: fullname: Tian – volume: 7 start-page: 488 year: 2006 ident: 10.1016/j.apsb.2021.03.024_bib120 article-title: Evaluation of clustering algorithms for protein–protein interaction networks publication-title: BMC Bioinf doi: 10.1186/1471-2105-7-488 contributor: fullname: Brohée – volume: 11 start-page: 110 year: 2013 ident: 10.1016/j.apsb.2021.03.024_bib10 article-title: Traditional Chinese medicine network pharmacology: theory, methodology and application publication-title: Chin J Nat Med doi: 10.3724/SP.J.1009.2013.00110 contributor: fullname: Li – volume: 12 start-page: 48 year: 2018 ident: 10.1016/j.apsb.2021.03.024_bib74 article-title: Study on the interaction between active components from traditional Chinese medicine and plasma proteins publication-title: Chem Cent J doi: 10.1186/s13065-018-0417-2 contributor: fullname: Jiao – volume: 39 start-page: 975 year: 2018 ident: 10.1016/j.apsb.2021.03.024_bib154 article-title: Main active constituent identification in Guanxinjing capsule, a traditional Chinese medicine, for the treatment of coronary heart disease complicated with depression publication-title: Acta Pharmacol Sin doi: 10.1038/aps.2017.117 contributor: fullname: Zhang – volume: 6 start-page: 21146 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib52 article-title: BATMAN-TCM: a bioinformatics analysis tool for molecular mechanism of traditional Chinese medicine publication-title: Sci Rep doi: 10.1038/srep21146 contributor: fullname: Liu – volume: 165 start-page: 2475 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib64 article-title: Chemical characteristic and bioactivity of hemicellulose-based polysaccharides isolated from Salvia miltiorrhiza publication-title: Int J Biol Macromol doi: 10.1016/j.ijbiomac.2020.10.113 contributor: fullname: Zhao – volume: 67 start-page: 5289 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib60 article-title: Untargeted and targeted fingerprinting of extra virgin olive oil volatiles by comprehensive two-dimensional gas chromatography with mass spectrometry: challenges in long-term studies publication-title: J Agric Food Chem doi: 10.1021/acs.jafc.9b01661 contributor: fullname: Stilo – volume: 16 start-page: 176 year: 1999 ident: 10.1016/j.apsb.2021.03.024_bib132 article-title: Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives publication-title: Pharm Res doi: 10.1023/A:1011907920641 contributor: fullname: Derendorf – volume: 10 start-page: 415 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib35 article-title: Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment publication-title: Cell Death Dis doi: 10.1038/s41419-019-1638-6 contributor: fullname: Lv – volume: 55 start-page: 1233 year: 2003 ident: 10.1016/j.apsb.2021.03.024_bib135 article-title: Clinical application of artificial neural network (ANN) modeling to predict pharmacokinetic parameters of severely ill patients publication-title: Adv Drug Deliv Rev doi: 10.1016/S0169-409X(03)00121-2 contributor: fullname: Yamamura – volume: 25 start-page: 25 year: 2000 ident: 10.1016/j.apsb.2021.03.024_bib95 article-title: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium publication-title: Nat Genet doi: 10.1038/75556 contributor: fullname: Ashburner – volume: 21 start-page: 827 year: 2005 ident: 10.1016/j.apsb.2021.03.024_bib118 article-title: PDZBase: a protein–protein interaction database for PDZ-domains publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti098 contributor: fullname: Beuming – volume: 120 start-page: 960 year: 2018 ident: 10.1016/j.apsb.2021.03.024_bib133 article-title: Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine publication-title: Br J Anaesth doi: 10.1016/j.bja.2017.11.100 contributor: fullname: Li – volume: 32 start-page: 2167 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib121 article-title: Characterizing gene sets using discriminative random walks with restart on heterogeneous biological networks publication-title: Bioinformatics doi: 10.1093/bioinformatics/btw151 contributor: fullname: Blatti – volume: 118 start-page: 109252 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib31 article-title: The interaction between the gut microbiota and herbal medicines publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2019.109252 contributor: fullname: An – volume: 166 start-page: 52 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib37 article-title: Study on the herb–herb interaction of Danqi Tongmai Tablet based on the pharmacokinetics of twelve notoginsenoides in acute myocardial ischemia and sham rats publication-title: J Pharmaceut Biomed Anal doi: 10.1016/j.jpba.2018.12.043 contributor: fullname: Zhi – volume: 9 start-page: 1113 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib40 article-title: Current trends in drug metabolism and pharmacokinetics publication-title: Acta Pharm Sin B doi: 10.1016/j.apsb.2019.10.001 contributor: fullname: Li – volume: 28 start-page: 416 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib93 article-title: International cancer genome Consortium (ICGC) publication-title: Med Genet-Berlin contributor: fullname: Siebert – volume: 40 start-page: D841 year: 2012 ident: 10.1016/j.apsb.2021.03.024_bib119 article-title: The IntAct molecular interaction database in 2012 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkr1088 contributor: fullname: Kerrien – volume: 236 start-page: 277 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib20 article-title: TCM-ADMEpred: a novel strategy for poly-pharmacokinetics prediction of traditional Chinese medicine based on single constituent pharmacokinetics, structural similarity, and mathematical modeling publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2018.07.008 contributor: fullname: Wang – volume: 46 start-page: 226 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib71 article-title: Comparative pharmacokinetics and a clinical laboratory evaluation of intravenous acetaminophen in Beagle and Galgo Español dogs publication-title: Vet Anaesth Analg doi: 10.1016/j.vaa.2018.09.042 contributor: fullname: Serrano-Rodríguez – volume: 47 start-page: D607 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib111 article-title: STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets publication-title: Nucleic Acids Res doi: 10.1093/nar/gky1131 contributor: fullname: Szklarczyk – volume: 18 start-page: 551 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib123 article-title: Network propagation: a universal amplifier of genetic associations publication-title: Nat Rev Genet doi: 10.1038/nrg.2017.38 contributor: fullname: Cowen – volume: 25 start-page: 671 year: 2003 ident: 10.1016/j.apsb.2021.03.024_bib69 article-title: Population pharmacokinetics of hydroxychloroquine in patients with rheumatoid arthritis publication-title: Ther Drug Monit doi: 10.1097/00007691-200312000-00005 contributor: fullname: Carmichael – volume: 39 start-page: 357 year: 2014 ident: 10.1016/j.apsb.2021.03.024_bib14 article-title: Integrative pharmacology: new paradigm of modernization of Chinese medicine publication-title: China J Chin Mater Med contributor: fullname: Xu – volume: 328 start-page: 1662 year: 2010 ident: 10.1016/j.apsb.2021.03.024_bib83 article-title: Reconstituting organ-level lung functions on a chip publication-title: Science doi: 10.1126/science.1188302 contributor: fullname: Huh – volume: 4 start-page: 759 year: 2008 ident: 10.1016/j.apsb.2021.03.024_bib19 article-title: Structure–ADME relationship: still a long way to go?. publication-title: Expert Opin Drug Met doi: 10.1517/17425255.4.6.759 contributor: fullname: Hou – volume: 6 start-page: 568 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib53 article-title: Identification and differentiation of Panax ginseng, Panax quinquefolium, and Panax notoginseng by monitoring multiple diagnostic chemical markers publication-title: Acta Pharm Sin B doi: 10.1016/j.apsb.2016.05.005 contributor: fullname: Yang – volume: 10 start-page: 1646 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib39 article-title: Transporters (OATs and OATPs) contribute to illustrate the mechanism of medicinal compatibility of ingredients with different properties in yuanhuzhitong prescription publication-title: Acta Pharm Sin B doi: 10.1016/j.apsb.2020.05.012 contributor: fullname: Wang – volume: 48 start-page: D845 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib110 article-title: The DisGeNET knowledge platform for disease genomics: 2019 update publication-title: Nucleic Acids Res contributor: fullname: Piñero – volume: 12 start-page: 17 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib25 article-title: High performance enzyme kinetics of turnover, activation and inhibition for translational drug discovery publication-title: Expet Opin Drug Discov doi: 10.1080/17460441.2017.1245721 contributor: fullname: Zhang – volume: 20 start-page: 389 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib44 article-title: Deep learning: new computational modelling techniques for genomics publication-title: Nat Rev Genet doi: 10.1038/s41576-019-0122-6 contributor: fullname: Eraslan – volume: 17 start-page: 215 year: 2000 ident: 10.1016/j.apsb.2021.03.024_bib4 article-title: The influence of natural products upon drug discovery publication-title: Nat Prod Rep doi: 10.1039/a902202c contributor: fullname: Newman – volume: 846 start-page: 1 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib43 article-title: Computational network biology: data, models, and applications publication-title: Phys Rep doi: 10.1016/j.physrep.2019.12.004 contributor: fullname: Liu – volume: 12 start-page: 2165 year: 2012 ident: 10.1016/j.apsb.2021.03.024_bib79 article-title: Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow publication-title: Lab Chip doi: 10.1039/c2lc40074j contributor: fullname: Kim – volume: 47 start-page: D976 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib50 article-title: ETCM: an encyclopaedia of traditional Chinese medicine publication-title: Nucleic Acids Res doi: 10.1093/nar/gky987 contributor: fullname: Xu – volume: 12 start-page: 89 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib75 article-title: New experimental models of the blood–brain barrier for CNS drug discovery publication-title: Expert Opin Drug Discov doi: 10.1080/17460441.2017.1253676 contributor: fullname: Kaisar – volume: 9 start-page: 10133 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib126 article-title: Centrality in complex networks with overlapping community structure publication-title: Sci Rep doi: 10.1038/s41598-019-46507-y contributor: fullname: Ghalmane – volume: 47 start-page: 1443 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib140 article-title: A new concept on quality marker of Chinese materia medica: quality control for Chinese medicinal products publication-title: Chin Tradit Herb Drugs contributor: fullname: Liu – volume: 17 start-page: 1217 year: 2011 ident: 10.1016/j.apsb.2021.03.024_bib3 article-title: The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine publication-title: Nat Med doi: 10.1038/nm.2471 contributor: fullname: Tu – volume: 98 start-page: 786 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib63 article-title: Structural analysis of a homogeneous polysaccharide from Achatina fulica publication-title: Int J Biol Macromol doi: 10.1016/j.ijbiomac.2017.01.149 contributor: fullname: Liu – volume: 51 start-page: 1132 year: 2011 ident: 10.1016/j.apsb.2021.03.024_bib12 article-title: Fangjiomics: in search of effective and safe combination therapies publication-title: J Clin Pharmacol doi: 10.1177/0091270010382913 contributor: fullname: Wang – volume: 22 start-page: bbaa082 year: 2021 ident: 10.1016/j.apsb.2021.03.024_bib99 article-title: gutMEGA: a database of the human gut MEtaGenome Atlas publication-title: Brief Bioinform doi: 10.1093/bib/bbaa082 contributor: fullname: Zhang – volume: 48 start-page: 3850 year: 2004 ident: 10.1016/j.apsb.2021.03.024_bib84 article-title: [18F]Ciprofloxacin, a new positron emission tomography tracer for noninvasive assessment of the tissue distribution and pharmacokinetics of ciprofloxacin in humans publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.48.10.3850-3857.2004 contributor: fullname: Brunner – volume: 27 start-page: 91 year: 2006 ident: 10.1016/j.apsb.2021.03.024_bib65 article-title: A strategy for preclinical formulation development using GastroPlus as pharmacokinetic simulation tool and a statistical screening design applied to a dog study publication-title: Eur J Pharmaceut Sci doi: 10.1016/j.ejps.2005.08.011 contributor: fullname: Kuentz – volume: 59 start-page: 3973 year: 2015 ident: 10.1016/j.apsb.2021.03.024_bib128 article-title: Optimization of polyene-azole combination therapy against aspergillosis using an in vitro pharmacokinetic–pharmacodynamic model publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.05035-14 contributor: fullname: Siopi – volume: 33 start-page: 681 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib103 article-title: Chemical proteomics approaches for identifying the cellular targets of natural products publication-title: Nat Prod Rep doi: 10.1039/C6NP00001K contributor: fullname: Wright – volume: 32 start-page: 576 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib22 article-title: Dissection of transporter function: from genetics to structure publication-title: Trends Genet doi: 10.1016/j.tig.2016.06.003 contributor: fullname: Diallinas – volume: 142 start-page: 176 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib30 article-title: Gut microbiota, a new frontier to understand traditional Chinese medicines publication-title: Pharmacol Res doi: 10.1016/j.phrs.2019.02.024 contributor: fullname: Feng – volume: 13 start-page: 255 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib70 article-title: Bioequivalence of two quetiapine extended release tablets in Chinese healthy volunteers under fasting and fed conditions and effects of food on pharmacokinetic profiles publication-title: Drug Des Dev Ther doi: 10.2147/DDDT.S182965 contributor: fullname: Huang – volume: 28 start-page: 691 year: 2011 ident: 10.1016/j.apsb.2021.03.024_bib27 article-title: Nucleic acid drug delivery and targeting publication-title: Pharm Res doi: 10.1007/s11095-011-0394-9 contributor: fullname: Takakura – volume: 10 start-page: 446 year: 2010 ident: 10.1016/j.apsb.2021.03.024_bib131 article-title: A microfluidic device for a pharmacokinetic–pharmacodynamic (PK–PD) model on a chip publication-title: Lab Chip doi: 10.1039/b917763a contributor: fullname: Sung – volume: 11 start-page: 417 year: 2010 ident: 10.1016/j.apsb.2021.03.024_bib9 article-title: Molecular networks for the study of TCM pharmacology publication-title: Brief Bioinform doi: 10.1093/bib/bbp063 contributor: fullname: Zhao – volume: 12 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib136 article-title: Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns publication-title: Dis Model Mech doi: 10.1242/dmm.038224 contributor: fullname: Brommage – volume: 107 start-page: 1082 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib41 article-title: Physiologically-based pharmacokinetic models for evaluating membrane transporter mediated drug–drug interactions: current capabilities, case studies, future opportunities, and recommendations publication-title: Clin Pharmacol Ther doi: 10.1002/cpt.1693 contributor: fullname: Taskar – volume: 9 start-page: 15889 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib42 article-title: A new strategy for identifying mechanisms of drug–drug interaction using transcriptome analysis: compound kushen injection as a proof of principle publication-title: Sci Rep doi: 10.1038/s41598-019-52375-3 contributor: fullname: Shen – volume: 44 start-page: D1045 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib88 article-title: BindingDB in 2015: a public database for medicinal chemistry, computational chemistry and systems pharmacology publication-title: Nucleic Acids Res doi: 10.1093/nar/gkv1072 contributor: fullname: Gilson – volume: 2104 start-page: 337 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib89 article-title: Using MetaboAnalyst 4.0 for metabolomics data analysis, interpretation, and integration with other omics data publication-title: Methods Mol Biol doi: 10.1007/978-1-0716-0239-3_17 contributor: fullname: Chong – volume: 31 start-page: 21 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib156 article-title: Study on analgesic effect and dose–effect relationship of Yuanhuzhitong prescrption on mice model of pain publication-title: Res Pract Chin Med contributor: fullname: Li – volume: 36 start-page: 1578 year: 2008 ident: 10.1016/j.apsb.2021.03.024_bib46 article-title: Plasma and urinary tanshinol from Salvia miltiorrhiza (Danshen) can be used as pharmacokinetic markers for cardiotonic pills, a cardiovascular herbal medicine publication-title: Drug Metab Dispos doi: 10.1124/dmd.108.021592 contributor: fullname: Lu – volume: 10 start-page: 2441 year: 2014 ident: 10.1016/j.apsb.2021.03.024_bib96 article-title: KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway analysis using a path analysis model publication-title: Mol Biosyst doi: 10.1039/C4MB00287C contributor: fullname: Du – volume: 19 start-page: 87 year: 2002 ident: 10.1016/j.apsb.2021.03.024_bib134 article-title: Modeling the pharmacokinetics and pharmacodynamics of a unique oral hypoglycemic agent using neural networks publication-title: Pharm Res doi: 10.1023/A:1013611617787 contributor: fullname: Haidar – volume: 21 start-page: 287 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib152 article-title: Tongmai Yangxin intervening in myocardial remodeling after PCI for coronary heart disease: study protocol for a double-blind, randomized controlled trial publication-title: Trials doi: 10.1186/s13063-020-4208-4 contributor: fullname: Wang – volume: 40 start-page: D857 year: 2012 ident: 10.1016/j.apsb.2021.03.024_bib115 article-title: MINT, the molecular interaction database: 2012 update publication-title: Nucleic Acids Res doi: 10.1093/nar/gkr930 contributor: fullname: Licata – volume: 85 start-page: 1684 year: 2013 ident: 10.1016/j.apsb.2021.03.024_bib129 article-title: PK/PD assessment in CNS drug discovery: prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2013.02.021 contributor: fullname: Caruso – volume: 6 start-page: 1941 year: 2012 ident: 10.1016/j.apsb.2021.03.024_bib146 article-title: Study on the application of intestinal absorption in vitro coupled with bioactivity assessment in Yuanhu Zhitong preparation publication-title: J Med Plants Res contributor: fullname: Zhang – volume: 19 start-page: 4182 year: 2013 ident: 10.1016/j.apsb.2021.03.024_bib23 article-title: The role of protonation states in ligand–receptor recognition and binding publication-title: Curr Pharmaceut Des doi: 10.2174/1381612811319230004 contributor: fullname: Petukh – volume: 232 start-page: 183 year: 2002 ident: 10.1016/j.apsb.2021.03.024_bib72 article-title: Simulated intestinal fluid as transport medium in the Caco-2 cell culture model publication-title: Int J Pharm doi: 10.1016/S0378-5173(01)00897-3 contributor: fullname: Ingels – volume: 43 start-page: 1297 year: 2018 ident: 10.1016/j.apsb.2021.03.024_bib15 article-title: Modern research progress of traditional Chinese medicine based on integrative pharmacology publication-title: China J Chin Mater Med contributor: fullname: Wang – volume: 155 start-page: 41 year: 2018 ident: 10.1016/j.apsb.2021.03.024_bib81 article-title: A nephron model for study of drug-induced acute kidney injury and assessment of drug-induced nephrotoxicity publication-title: Biomaterials doi: 10.1016/j.biomaterials.2017.11.010 contributor: fullname: Qu – volume: 47 start-page: D1018 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib107 article-title: Expansion of the human phenotype ontology (HPO) knowledge base and resources publication-title: Nucleic Acids Res doi: 10.1093/nar/gky1105 contributor: fullname: Köhler – volume: 117 start-page: 93 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib32 article-title: Can probiotics modulate human disease by impacting intestinal barrier function?. publication-title: Br J Nutr doi: 10.1017/S0007114516004037 contributor: fullname: Bron – volume: 47 start-page: D930 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib51 article-title: ChEMBL: towards direct deposition of bioassay data publication-title: Nucleic Acids Res doi: 10.1093/nar/gky1075 contributor: fullname: Mendez – volume: 13 start-page: 1763 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib66 article-title: In silico modeling of gastrointestinal drug absorption: predictive performance of three physiologically based absorption models publication-title: Mol Pharm doi: 10.1021/acs.molpharmaceut.5b00861 contributor: fullname: Sjögren – volume: 167 start-page: W21 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib8 article-title: CONSORT extension for Chinese herbal medicine formulas 2017: recommendations, explanation, and elaboration (simplified Chinese version) publication-title: Ann Intern Med doi: 10.7326/IsTranslatedFrom_M17-2977_2 contributor: fullname: Cheng – volume: 32 start-page: D449 year: 2004 ident: 10.1016/j.apsb.2021.03.024_bib117 article-title: The database of interacting proteins: 2004 update publication-title: Nucleic Acids Res doi: 10.1093/nar/gkh086 contributor: fullname: Salwinski – volume: 30 start-page: 523 year: 2014 ident: 10.1016/j.apsb.2021.03.024_bib122 article-title: Causal analysis approaches in ingenuity pathway analysis publication-title: Bioinformatics doi: 10.1093/bioinformatics/btt703 contributor: fullname: Krämer – volume: 32 start-page: 760 year: 2014 ident: 10.1016/j.apsb.2021.03.024_bib78 article-title: Microfluidic organs-on-chips publication-title: Nat Biotechnol doi: 10.1038/nbt.2989 contributor: fullname: Bhatia – volume: 21 start-page: 403 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib106 article-title: 2020 FDA drug–drug interaction guidance: a comparison analysis and action plan by pharmaceutical industrial scientists publication-title: Curr Drug Metabol doi: 10.2174/1389200221666200620210522 contributor: fullname: Sudsakorn – volume: 53 start-page: 53 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib149 article-title: Poly-pharmacokinetic strategy-delineated metabolic fate of bioactive compounds in a traditional Chinese medicine formula, Yuanhu Zhitong tablets, using parallel reaction monitoring mode publication-title: Phytomedicine doi: 10.1016/j.phymed.2018.09.026 contributor: fullname: Wang – volume: 76 start-page: 473 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib29 article-title: An insight into gut microbiota and its functionalities publication-title: Cell Mol Life Sci doi: 10.1007/s00018-018-2943-4 contributor: fullname: Adak – volume: 371 start-page: 2239 year: 2014 ident: 10.1016/j.apsb.2021.03.024_bib7 article-title: Oral arsenic and retinoic acid for non-high-risk acute promyelocytic leukemia publication-title: N Engl J Med doi: 10.1056/NEJMc1412035 contributor: fullname: Zhu – volume: 48 start-page: D1031 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib87 article-title: Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics publication-title: Nucleic Acids Res contributor: fullname: Wang – volume: 9 start-page: 552 year: 2015 ident: 10.1016/j.apsb.2021.03.024_bib17 article-title: Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula publication-title: ISME J doi: 10.1038/ismej.2014.177 contributor: fullname: Xu – volume: 38 start-page: 1141 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib47 article-title: A new method to evaluate the dose–effect relationship of a TCM formula Gegen Qinlian Decoction: "Focus" mode of integrated biomarkers publication-title: Acta Pharmacol Sin doi: 10.1038/aps.2016.165 contributor: fullname: Huang – volume: 567 start-page: 67 year: 2004 ident: 10.1016/j.apsb.2021.03.024_bib26 article-title: Conformational change in substrate binding, catalysis and product release: an open and shut case?. publication-title: FEBS Lett doi: 10.1016/j.febslet.2004.03.067 contributor: fullname: Gutteridge – volume: 87 start-page: 1123 year: 2010 ident: 10.1016/j.apsb.2021.03.024_bib48 article-title: ChemSpider: an online chemical information resource publication-title: J Chem Educ doi: 10.1021/ed100697w contributor: fullname: Pence – volume: 15 start-page: 858 year: 2015 ident: 10.1016/j.apsb.2021.03.024_bib77 article-title: Evaluating potential P-gp substrates: main aspects to choose the adequate permeability model for assessing gastrointestinal drug absorption publication-title: Mini Rev Med Chem doi: 10.2174/1389557515666150511152705 contributor: fullname: da Silva Junior – volume: 2013 start-page: 658531 year: 2013 ident: 10.1016/j.apsb.2021.03.024_bib150 article-title: A computational drug–target network for yuanhu zhitong prescription publication-title: Evid Based Complement Alternat Med doi: 10.1155/2013/658531 contributor: fullname: Xu – volume: 15 start-page: 1005 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib130 article-title: Pharmacokinetic and pharmacodynamic insights from microfluidic intestine-on-a-chip models publication-title: Expert Opin Drug Metab Toxicol doi: 10.1080/17425255.2019.1700950 contributor: fullname: Lee – volume: 47 start-page: D506 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib91 article-title: UniProt: a worldwide hub of protein knowledge publication-title: Nucleic Acids Res doi: 10.1093/nar/gky1049 – volume: 26 start-page: 252 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib104 article-title: Obese individuals with and without type 2 diabetes show different gut microbial functional capacity and composition publication-title: Cell Host Microbe doi: 10.1016/j.chom.2019.07.004 contributor: fullname: Thingholm – volume: 216 start-page: 107698 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib16 article-title: Current state and future perspective of cardiovascular medicines derived from natural products publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2020.107698 contributor: fullname: Zhao – volume: 7 start-page: 439 year: 2017 ident: 10.1016/j.apsb.2021.03.024_bib45 article-title: Approaches to establish Q-markers for the quality standards of traditional Chinese medicines publication-title: Acta Pharm Sin B doi: 10.1016/j.apsb.2017.04.012 contributor: fullname: Yang – volume: 38 start-page: 2746 year: 2015 ident: 10.1016/j.apsb.2021.03.024_bib138 article-title: Development of immunoaffinity chromatography to specifically knockout baicalin from Gegenqinlian Decoction publication-title: J Separ Sci doi: 10.1002/jssc.201500168 contributor: fullname: Zhao – volume: 123 start-page: 766 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib62 article-title: Multi-fingerprint profiling combined with chemometric methods for investigating the quality of Astragalus polysaccharides publication-title: Int J Biol Macromol doi: 10.1016/j.ijbiomac.2018.11.037 contributor: fullname: Li – volume: 38 start-page: 1987 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib34 article-title: Connection between gut microbiome and the development of obesity publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-019-03623-x contributor: fullname: Zhi – volume: 46 start-page: D649 year: 2018 ident: 10.1016/j.apsb.2021.03.024_bib97 article-title: The reactome pathway knowledgebase publication-title: Nucleic Acids Res doi: 10.1093/nar/gkx1132 contributor: fullname: Fabregat – volume: 893 start-page: 65 year: 2015 ident: 10.1016/j.apsb.2021.03.024_bib59 article-title: A green protocol for efficient discovery of novel natural compounds: characterization of new ginsenosides from the stems and leaves of Panax ginseng as a case study publication-title: Anal Chim Acta doi: 10.1016/j.aca.2015.08.048 contributor: fullname: Qiu – volume: 48 start-page: D545 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib98 article-title: GMrepo: a database of curated and consistently annotated human gut metagenomes publication-title: Nucleic Acids Res doi: 10.1093/nar/gkz764 contributor: fullname: Wu – volume: 25 start-page: 1442 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib100 article-title: A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research publication-title: Nat Med doi: 10.1038/s41591-019-0559-3 contributor: fullname: Poyet – volume: 13 start-page: 3599 year: 2013 ident: 10.1016/j.apsb.2021.03.024_bib82 article-title: Microfluidic heart on a chip for higher throughput pharmacological studies publication-title: Lab Chip doi: 10.1039/c3lc50350j contributor: fullname: Agarwal – volume: 12 start-page: 233 year: 2016 ident: 10.1016/j.apsb.2021.03.024_bib151 article-title: Identification of key active constituents of Buchang Naoxintong capsules with therapeutic effects against ischemic stroke by using an integrative pharmacology-based approach publication-title: Mol Biosyst doi: 10.1039/C5MB00460H contributor: fullname: Xu – volume: 37 start-page: W623 year: 2009 ident: 10.1016/j.apsb.2021.03.024_bib49 article-title: PubChem: a public information system for analyzing bioactivities of small molecules publication-title: Nucleic Acids Res doi: 10.1093/nar/gkp456 contributor: fullname: Wang – volume: 13 start-page: 343 year: 2001 ident: 10.1016/j.apsb.2021.03.024_bib73 article-title: Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation publication-title: Eur J Pharmaceut Sci doi: 10.1016/S0928-0987(01)00135-X contributor: fullname: LeCluyse – volume: 37 start-page: D767 year: 2009 ident: 10.1016/j.apsb.2021.03.024_bib116 article-title: Human protein reference database—2009 update publication-title: Nucleic Acids Res doi: 10.1093/nar/gkn892 contributor: fullname: Keshava Prasad – volume: 99 year: 2020 ident: 10.1016/j.apsb.2021.03.024_bib153 article-title: Clinical study on post evaluation after listing of Qizhi Weitong granules: study protocol clinical trial (SPIRIT compliant) publication-title: Medicine (Baltim) contributor: fullname: Xu – volume: 1599 start-page: 125 year: 2019 ident: 10.1016/j.apsb.2021.03.024_bib54 article-title: Integrated liquid chromatography–mass spectrometry and nuclear magnetic resonance spectra for the comprehensive characterization of various components in the Shuxuening injection publication-title: J Chromatogr A doi: 10.1016/j.chroma.2019.04.008 contributor: fullname: Yu |
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