Immunohistochemical determination of the site of hypotensive effects of glucagon-like peptide-2 in the rat brain

Highlights ► GLP-2 (i.v. and i.c.v.) reduced mean arterial blood pressure in anesthetized rats. ► Administered GLP-2 induced Fos-immunoreactivity in the NTS and CVLM. ► It also induced Fos-immunoreactivity of GABAergic neurons in the NTS, CVLM and PVH. ► GLP-2 may inhibit sympathetic nerve activity...

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Bibliographic Details
Published in:	Neuroscience Vol. 212; pp. 140 - 148
Main Authors:	Sasaki-Hamada, S, Okada, S, Ito, K, Iwai, T, Oka, J.-I
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Ltd 14-06-2012 Elsevier
Subjects:	Anesthetics - administration & dosage Animals area postrema Biological and medical sciences Blood pressure Blood Pressure - drug effects Blood Pressure - physiology Brain Brain Chemistry - drug effects Brain Chemistry - physiology Brain stem c-Fos c-Fos protein Catecholamines Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Energy Fos protein Fundamental and applied biological sciences. Psychology Gastrointestinal tract GLP-2 Glucagon-like peptide 2 Glucagon-Like Peptide 2 - chemistry Glucagon-Like Peptide 2 - physiology heart rate Hypotension Hypotension - chemically induced Hypotension - metabolism immunohistochemistry Male Medulla oblongata Nervous system Neural Inhibition - drug effects Neural Inhibition - physiology Neurology Neurons Proto-Oncogene Proteins c-fos - chemistry Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Inbred WF Solitary Nucleus - chemistry Solitary Nucleus - drug effects Solitary Nucleus - physiology Solitary tract nucleus sympathetic nerves urethane Vertebrates: nervous system and sense organs dorsomedial hypothalamic nucleus PVH glucagon-like peptide-2 Fos-immunoreactivity c-Fos CNS HR NTS locus coeruleus area postrema intravenous A5 caudal ventrolateral medulla c-fos protein intracerebroventricular A5 catecholamine cell group immunohistochemistry DMH diaminobenzidine blood pressure heart rate rostral ventrolateral medulla RVLM DAB nucleus of the solitary tract Fos-IR CVLM Fos GAD AP central nervous system glutamic acid decarboxylase tyrosine hydroxylase i.v VMH ventromedial hypothalamic nucleus TH paraventricular nucleus of the thalamus LC mean arterial blood pressure i.c.v GLP-2 MAP Immunohistochemistry Ependymal organ Rat fos Gene Rodentia Central nervous system Glucagon-like peptide II Encephalon Heart rate Vertebrata Mammalia Area postrema Animal Blood pressure Hemodynamics Protooncogene Immediate early gene
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