Identification of a 20-Gene Expression-Based Risk Score as a Predictor of Clinical Outcome in Chronic Lymphocytic Leukemia Patients

Despite the improvement in treatment options, chronic lymphocytic leukemia (CLL) remains an incurable disease and patients show a heterogeneous clinical course requiring therapy for many of them. In the current work, we have built a 20-gene expression (GE)-based risk score predictive for patients ov...

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Bibliographic Details
Published in:	BioMed research international Vol. 2014; no. 2014; pp. 1 - 10
Main Authors:	Bou Samra, Elias, Klein, Bernard, Commes, Thérèse, Moreaux, Jérôme
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Puplishing Corporation 01-01-2014 Hindawi Publishing Corporation John Wiley & Sons, Inc Hindawi Limited
Subjects:	Adaptor Proteins, Signal Transducing - biosynthesis Cell adhesion & migration Chemokines Chronic lymphocytic leukemia Clinical outcomes Deoxyribonucleic acid DNA DNA repair Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Humans Immunology Kinases Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Life Sciences Medical prognosis Microarray Analysis Multivariate analysis Mutation Neoplasm Proteins - biosynthesis Nuclear Proteins - biosynthesis Patient outcomes Prognosis Risk factors Survival Analysis T Cell Transcription Factor 1 - biosynthesis Treatment Outcome France gene expression chronic lymphocytic leukemia
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