Neuroprotective effects of vinpocetine, as a phosphodiesterase 1 inhibitor, on long-term potentiation in a rat model of Alzheimer's disease

• Published in: BMC neuroscience Vol. 24; no. 1; p. 20
• Main Authors: Shekarian, Meysam, Salehi, Iraj, Raoufi, Safoura, Asadbegi, Masoumeh, Kourosh-Arami, Masoumeh, Komaki, Alireza
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 16-03-2023; BioMed Central; BMC
• Subjects: Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Animal cognition; Animal models; Animals; Anti-inflammatory agents; Beta-amyloid; Brain; Care and treatment; Dentate gyrus; Development and progression; Drug dosages; Electrodes; Excitatory postsynaptic potentials; Hippocampal plasticity; Hippocampus; Hippocampus - metabolism; Inflammation; Kinases; Long-Term Potentiation; Male; Memory; Neurodegenerative diseases; Neuroprotection; Neuroprotective agents; Neuroprotective Agents - pharmacology; Oral administration; Oxidative stress; Peptide Fragments - pharmacology; Peptides; Phosphodiesterase; Phosphodiesterase1 inhibitor; Phosphoric Diester Hydrolases - adverse effects; Phosphoric Diester Hydrolases - metabolism; Proteins; Rats; Rats, Wistar; Stereotaxic surgery; Surveillance; Synaptic plasticity; Testing; Vinpocetine; β-Amyloid; Iran; United States > US; Phosphodiesterase1 inhibitor; Alzheimer’s disease; Long-term potentiation; Hippocampus; Beta-amyloid; Vinpocetine
• DOI: 10.1186/s12868-023-00790-8
• EISSN: 1471-2202

Vinpocetine (Vin) is known as a phosphodiesterase 1 inhibitor (PDE1-I) drug with multilateral effects, including antioxidant and anti-inflammatory activity. In this research, we investigated the neuroprotective and therapeutic effects of Vin through hippocampal synaptic plasticity on a rat's model of Alzheimer's disease (AD) induced by an intracerebroventricular (ICV) injection of beta-amyloid (Aβ).
Sixty adult male Wistar rats were randomly divided into six groups: 1. control, 2. sham, 3. Aβ, 4. pretreatment (Vin + Aβ): Vin (4 mg/kg, gavage) for 30 days and then, inducing an AD model by an ICV injection of Aβ(1-42), 5. treatment (Aβ + Vin): inducing an AD model and then receiving Vin for 30 days by gavage, and 7. pretreatment + treatment (Vin + Aβ + Vin): receiving Vin by gavage for 30 days before and 30 days after the induction of an AD model. After these procedures, via stereotaxic surgery, the stimulating electrodes were placed at the perforant pathway (PP) and the recording electrodes were implanted in the dentate gyrus.
Excitatory postsynaptic potential (EPSP) slope and population spike (PS) amplitude in the Aβ group meaningfully diminished compared to the control group after the induction of long-term potentiation (LTP).
Vin could significantly prevent the Aβ effects on LTP. It can be concluded that pretreatment and treatment with Vin can be neuroprotective against harmful consequences of Aβ on hippocampal synaptic plasticity.