Schistosoma mansoni-mediated suppression of allergic airway inflammation requires patency and Foxp3+ Treg cells

The continual rise of asthma in industrialised countries stands in strong contrast to the situation in developing lands. According to the modified Hygiene Hypothesis, helminths play a major role in suppressing bystander immune responses to allergens, and both epidemiological and experimental studies...

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Bibliographic Details
Published in:	PLoS neglected tropical diseases Vol. 7; no. 8; p. e2379
Main Authors:	Layland, Laura E, Straubinger, Kathrin, Ritter, Manuel, Loffredo-Verde, Eva, Garn, Holger, Sparwasser, Tim, Prazeres da Costa, Clarissa
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 2013 Public Library of Science (PLoS)
Subjects:	Allergens - immunology Allergies Animals Asthma Asthma - complications Asthma - immunology Asthma - pathology Biology Disease Models, Animal Eggs Experiments Female Flow cytometry Forkhead Transcription Factors - analysis Hygiene Hypotheses Immune system Immune Tolerance Immunoglobulin E - blood Infections Lung - pathology Lymphocyte Depletion Lymphocytes Medicine Mice Mice, Inbred BALB C Mice, Inbred C57BL Ovalbumin - immunology Rodents Schistosoma mansoni - immunology Schistosomiasis mansoni - complications Schistosomiasis mansoni - immunology Schistosomiasis mansoni - pathology T-Lymphocyte Subsets - chemistry T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - chemistry T-Lymphocytes, Regulatory - immunology Allergens Ovalbumin Schistosoma mansoni T-Lymphocyte Subsets Lung Mice, Inbred C57BL Immune Tolerance Immunoglobulin E Lymphocyte Depletion Asthma Schistosomiasis mansoni Animals T-Lymphocytes, Regulatory Female Mice Mice, Inbred BALB C Forkhead Transcription Factors Disease Models, Animal
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