High lymphocyte population-related predictive factors for a long-term response in non-small cell lung cancer patients treated with pemetrexed: a retrospective observational study

Regimens combining pemetrexed (PEM) and immune checkpoint inhibitors (ICIs) targeting programmed cell death-1 (PD-1) or programmed death-ligand 1 (PD-L1) are widely used for the treatment of advanced non-squamous non-small-cell lung cancer (NSq-NSCLC). Recently, PEM was shown to induce immunogenic c...

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Bibliographic Details
Published in:	Journal of translational medicine Vol. 19; no. 1; p. 92
Main Authors:	Sumiyoshi, Issei, Okabe, Takahiro, Togo, Shinsaku, Takagi, Haruhi, Motomura, Hiroaki, Ochi, Yusuke, Shimada, Naoko, Haraguchi, Mizuki, Shibayama, Rina, Fujimoto, Yuichi, Watanabe, Junko, Iwai, Moe, Kadoya, Kotaro, Iwakami, Shin-Ichiro, Takahashi, Kazuhisa
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 28-02-2021 BioMed Central BMC
Subjects:	Absolute lymphocyte count Antibodies Apoptosis B7-H1 Antigen Biomarkers Blood Blood cell count Carcinoma, Non-Small-Cell Lung - drug therapy Cell death Cell number Cloning Cytotoxicity Drug therapy Health aspects Humans Immune checkpoint inhibitors Immunogenic cell death Immunogenicity Leukocytes (neutrophilic) Lung cancer Lung cancer, Non-small cell Lung Neoplasms - drug therapy Lymphocyte Count Lymphocytes Neutrophil-to-lymphocyte ratio Non-small cell lung carcinoma Non-small-cell lung cancer Observational studies Paclitaxel Patient outcomes Patients PD-1 protein PD-L1 protein Pemetrexed Pemetrexed - therapeutic use Prognosis Programmed cell death-1 Reagents Small cell lung carcinoma Statistical analysis Tumors Variance analysis Japan United States > US California Programmed death-ligand 1 Neutrophil-to-lymphocyte ratio Absolute lymphocyte count Non-small-cell lung cancer Programmed cell death-1 Pemetrexed Immunogenic cell death
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