Effects of a Brazilian cardioprotective diet and nuts on cardiometabolic parameters after myocardial infarction: study protocol for a randomized controlled clinical trial

• Published in: Current controlled trials in cardiovascular medicine Vol. 22; no. 1; pp. 582 - 16
• Main Authors: Marcadenti, Aline, Weber, Bernardete, Bersch-Ferreira, Angela Cristine, Machado, Rachel Helena Vieira, Torreglosa, Camila Ragne, de Sousa Lara, Enilda Maria, da Silva, Lucas Ribeiro, Santos, Renato Hideo Nakagawa, Miyada, Debora Harumi Kodama, Sady, Erica Regina Ribeiro, Costa, Rosana Perim, Piegas, Leopoldo, de Abreu-Silva, Erlon Oliveira, de Quadros, Alexandre Schaan, Weschenfelder, Camila, Dos Santos, Júlia Lorenzon, Souza, Gabriela Corrêa, Parahiba, Suena Medeiros, Fayh, Ana Paula Trussardi, Bezerra, Danielle Soares, Carvalho, Ana Paula Perillo Ferreira, Machado, Malaine Morais Alves, Vasconcelos, Sandra Mary Lima, Araújo, Jéssika, de Figueiredo Neto, José Albuquerque, Dias, Luciana Pereira Pinto, Nagano, Francisca Eugenia Zaina, de Almeida, Cássia Cristina Paes, Moreira, Annie Seixas Bello, Gapanowicz, Débora Pinto, Purgatto, Eduardo, Rogero, Marcelo Macedo, Sampaio, Geni Rodrigues, da Silva Torres, Elizabeth Aparecida Ferraz, Duarte, Graziela Biude Silva, Cavalcanti, Alexandre Biasi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 01-09-2021; BioMed Central; BMC
• Subjects: Adult; Arachis; Atherosclerosis; Biomarkers; Blood Glucose; Cardiology; Cholesterol, LDL; Clinical trials; Diet; Diet therapy; Diet, Healthy; Eating behavior; Fatty acids; Food science; Health aspects; Heart attack; Heart attacks; Hospitals; Humans; Intervention; Laboratories; Mortality; Multicenter Studies as Topic; Myocardial infarction; Myocardial Infarction - diagnosis; Myocardial Infarction - prevention & control; Nutrition research; Nuts; Participation; Population; Prevention; Randomized Controlled Trials as Topic; Secondary prevention; Study Protocol; Brazil; Rio Grande do Norte Brazil; Rio Grande do Sul Brazil; Rio de Janeiro Brazil; Myocardial infarction; Nuts; Atherosclerosis; Secondary prevention; Bertholletia; Arachis; Diet, Healthy; Anacardium
• ISSN: 1745-6215; 1745-6215
• DOI: 10.1186/s13063-021-05494-0

Nut consumption has been related to improvements on cardiometabolic parameters and reduction in the severity of atherosclerosis mainly in primary cardiovascular prevention. The objective of this trial is to evaluate the effects of the Brazilian Cardioprotective Diet (DIeta CArdioprotetora Brasileira, DICA Br) based on consumption of inexpensive locally accessible foods supplemented or not with mixed nuts on cardiometabolic features in patients with previous myocardial infarction (MI).
DICA-NUTS study is a national, multicenter, randomized 16-week follow-up clinical trial. Patients over 40 years old with diagnosis of previous MI in the last 2 to 6 months will be recruited (n = 388). A standardized questionnaire will be applied to data collection and blood samples will be obtained. Patients will be allocated in two groups: Group 1: DICA Br supplemented with 30 g/day of mixed nuts (10 g of peanuts, 10 g of cashew, 10 g of Brazil nuts); and Group 2: only DICA Br. The primary outcome will consist of LDL cholesterol means (in mg/dL) after 16 weeks of intervention. Secondary outcomes will consist of other markers of lipid profile, glycemic profile, and anthropometric data.
It is expected that DICA Br supplemented with mixed nuts have superior beneficial effects on cardiometabolic parameters in patients after a MI, when compared to DICA Br.
ClinicalTrials.gov Identifier NCT03728127 . First register: November 1, 2018; Last update: June 16, 2021. World Health Organization Universal Trial Number (WHO-UTN): U1111-1259-8105.