Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity

Interactions between the gut microbiota, diet, and host metabolism contribute to the development of cardiovascular disease, but a firm link between disease-specific gut microbiota alterations and circulating metabolites is lacking. We performed shot-gun sequencing on 235 samples from 166 HF patients...

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Bibliographic Details
Published in:	Genome medicine Vol. 16; no. 1; pp. 27 - 12
Main Authors:	Raju, Sajan C, Molinaro, Antonio, Awoyemi, Ayodeji, Jørgensen, Silje F, Braadland, Peder R, Nendl, Andraz, Seljeflot, Ingebjørg, Ueland, Per M, McCann, Adrian, Aukrust, Pål, Vestad, Beate, Mayerhofer, Cristiane, Broch, Kaspar, Gullestad, Lars, Lappegård, Knut T, Halvorsen, Bente, Kristiansen, Karsten, Hov, Johannes R, Trøseid, Marius
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 08-02-2024 BioMed Central Springer Nature BMC
Subjects:	Cardiovascular diseases Comparative analysis Congestive heart failure Development and progression Digestive system Disease Dysbacteriosis Dysbiosis Ethylenediaminetetraacetic acid Etiology Fatty acids Food Gastrointestinal tract Genomes Gut microbiota Heart failure Heart Failure - metabolism Histidine Humans Imidazole Imidazole propionate Imidazoles Inflammation Intestinal microflora Metabolism Metabolites Microbiomes Microbiota Microbiota (Symbiotic organisms) Nutrition research Patient Acuity Permeability Physiological aspects Propionic acid Proteins Questionnaires Taxonomy Type 2 diabetes Germany Gut microbiota Heart failure Inflammation Imidazole propionate
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