Heterogeneous matrix stiffness regulates the cancer stem-like cell phenotype in hepatocellular carcinoma

Solid tumors are stiffer than their surrounding normal tissues; however, their interior stiffness is not uniform. Under certain conditions, cancer cells can acquire stem-like phenotypes. However, it remains unclear how the heterogeneous physical microenvironment affects stemness expression in cancer...

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Bibliographic Details
Published in:	Journal of translational medicine Vol. 20; no. 1; p. 555
Main Authors:	Wei, Jiayun, Yao, Jia, Yang, Chendong, Mao, Yongcui, Zhu, Dan, Xie, Ye, Liu, Pinyan, Yan, Mengchao, Ren, Longfei, Lin, Yan, Zheng, Qiuxia, Li, Xun
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 03-12-2022 BioMed Central BMC
Subjects:	Animal models Animals Antibodies Apoptosis Atomic force microscopy Cancer cell stemness Carcinoma, Hepatocellular - genetics Cell proliferation Cytology Cytoskeleton Diagnosis Genetic aspects Genotype & phenotype Health aspects Hepatocellular carcinoma Hepatoma Heterogeneity Hydrogels Immunofluorescence Liver cancer Liver Neoplasms - genetics Matrix stiffness Mechanical properties Mechanical stimuli Mechanotransduction Mechanotransduction, Cellular Microscopy Morphology Nuclear transport Patients Phenotype Phenotypes Solid tumors Stem cells Tumor Microenvironment Tumors Western blotting Yes-associated protein China Yes-associated protein Heterogeneity Hepatocellular carcinoma Cancer cell stemness Matrix stiffness
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