Application of the Mannich reaction in the structural modification of natural products

The Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the act...

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Bibliographic Details
Published in:	Journal of enzyme inhibition and medicinal chemistry Vol. 38; no. 1; p. 2235095
Main Authors:	Pu, Miao-Xia, Guo, Hong-Yan, Quan, Zhe-Shan, Li, Xiaoting, Shen, Qing-Kun
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 01-12-2023 Taylor & Francis Ltd Taylor & Francis Group
Subjects:	Biological activity Biological Products - pharmacology Cancer Cytotoxicity Mannich Bases - chemistry Mannich reaction Natural products Organic chemicals Pharmacy Prostate Review Toxicity Natural products Mannich reaction biological activity
Online Access:	Get full text
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Summary:	The Mannich reaction is commonly used to introduce N atoms into compound molecules and is thus widely applied in drug synthesis. The Mannich reaction accounts for a certain proportion of structural modifications of natural products. The introduction of Mannich bases can significantly improve the activity, hydrophilicity, and medicinal properties of compounds; therefore, the Mannich reaction is widely used for the structural modification of natural products. In this paper, the application of the Mannich reaction to the structural modification of natural products is reviewed, providing a method for the structural modification of natural products.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Miao-Xia Pu and Hong-Yan Guo contributed equally to this work.
ISSN:	1475-6366 1475-6374
DOI:	10.1080/14756366.2023.2235095