Predicting the Most Deleterious Missense Nonsynonymous Single-Nucleotide Polymorphisms of Hennekam Syndrome-Causing CCBE1 Gene, In Silico Analysis

Hennekam lymphangiectasia-lymphedema syndrome has been linked to single-nucleotide polymorphisms in the CCBE1 (collagen and calcium-binding EGF domains 1) gene. Several bioinformatics methods were used to find the most dangerous nsSNPs that could affect CCBE1 structure and function. Using state-of-t...

Full description

Saved in:

Bibliographic Details
Published in:	TheScientificWorld Vol. 2021; pp. 6642626 - 19
Main Authors:	Shinwari, Khyber, Guojun, Liu, Deryabina, Svetlana S., Bolkov, Mikhail A., Tuzankina, Irina A., Chereshnev, Valery A.
Format:	Journal Article
Language:	English
Published:	United States Hindawi 2021 John Wiley & Sons, Inc Hindawi Limited
Subjects:	Algorithms Amino acids Analysis Animal models Binding sites Bioinformatics Calcium Calcium-Binding Proteins - genetics Codons Collagen Computational Biology Craniofacial Abnormalities - genetics Disease Edema Extracellular matrix Forecasting Gene expression Genes Genetics Genomes Homology Humans Lymphangiectasis, Intestinal - genetics Lymphatic diseases Lymphatic system Lymphedema Lymphedema - genetics Medical research Medicine, Experimental Mutation Mutation, Missense - genetics Nucleotides Organisms Phosphorylation Polymorphism, Single Nucleotide - genetics Post-translation Precision medicine Protein binding Proteins Single nucleotide polymorphisms Single-nucleotide polymorphism Structure-function relationships Tumor Suppressor Proteins - genetics
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!