Changes in the inflammatory and oxidative stress markers during a single hemodialysis session in patients with chronic kidney disease
Background: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5-20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation a...
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Published in: | Renal failure Vol. 40; no. 1; pp. 534 - 540 |
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Abstract | Background: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5-20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease.
Methods: Twenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group.
Results: This study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls.
Conclusions: Hemodialysis procedure contributes to inflammation and oxidative stress. |
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AbstractList | Background: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5-20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease.
Methods: Twenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group.
Results: This study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls.
Conclusions: Hemodialysis procedure contributes to inflammation and oxidative stress. Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5-20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease. Twenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group. This study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls. Hemodialysis procedure contributes to inflammation and oxidative stress. Background : Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5–20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease. Methods: Twenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group. Results: This study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls. Conclusions: Hemodialysis procedure contributes to inflammation and oxidative stress. Background: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5–20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease. Methods: Twenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group. Results: This study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls. Conclusions: Hemodialysis procedure contributes to inflammation and oxidative stress. BACKGROUNDCardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5-20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease.METHODSTwenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group.RESULTSThis study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls.CONCLUSIONSHemodialysis procedure contributes to inflammation and oxidative stress. |
Author | Harini Devi, N. Suchitra, M. M. Siva Kumar, V. Srinivasa Rao, P. V. L. N. Sangeetha Lakshmi, B. |
Author_xml | – sequence: 1 givenname: B. surname: Sangeetha Lakshmi fullname: Sangeetha Lakshmi, B. organization: Department of Nephrology, Sri Venkateswara Institute of Medical Sciences – sequence: 2 givenname: N. surname: Harini Devi fullname: Harini Devi, N. organization: Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences – sequence: 3 givenname: M. M. surname: Suchitra fullname: Suchitra, M. M. organization: Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences – sequence: 4 givenname: P. V. L. N. surname: Srinivasa Rao fullname: Srinivasa Rao, P. V. L. N. email: seenupvln@yahoo.com organization: Department of Biochemistry, Sri Venkateswara Institute of Medical Sciences – sequence: 5 givenname: V. surname: Siva Kumar fullname: Siva Kumar, V. organization: Department of Nephrology, Sri Venkateswara Institute of Medical Sciences |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30277113$$D View this record in MEDLINE/PubMed |
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Cites_doi | 10.1093/ndt/14.suppl_1.76 10.1093/ndt/15.7.953 10.1016/S0140-6736(87)90266-2 10.1053/ajkd.1998.v32.pm9820470 10.1093/ndt/gfq273 10.1681/ASN.V1071606 10.4103/0971-4065.98758 10.1016/0003-2697(79)90738-3 10.1093/clinchem/18.6.499 10.1093/ndt/17.suppl_8.33 10.1046/j.1523-1755.1999.00613.x 10.1681/ASN.V13suppl_1s28 10.1515/CCLM.2002.019 10.2215/CJN.00870207 10.1016/j.tcm.2010.03.005 10.1053/j.ajkd.2009.06.022 10.1006/abio.1996.0292 10.2215/CJN.03670807 10.1161/01.CIR.102.6.636 10.1093/ndt/gfl747 10.1074/jbc.272.52.32817 10.5812/ircmj.22045 10.1097/01.ASN.0000143744.72664.66 10.1002/1529-0131(200112)44:12<2841::AID-ART472>3.0.CO;2-6 |
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Keywords | hemodialysis Cardiovascular disease inflammation oxidative stress; Pentraxin-3 |
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Snippet | Background: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among... Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5-20... BACKGROUNDCardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom... Background : Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among... |
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SubjectTerms | Adult Aged Biomarkers - blood C-Reactive Protein - analysis Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Case-Control Studies Clinical Study End-stage renal disease Female Hemodialysis Humans Immune response India inflammation Inflammation - blood Kidney diseases Kidney Failure, Chronic - complications Kidney Failure, Chronic - therapy Male Malondialdehyde - blood Middle Aged Morbidity Oxidative Stress oxidative stress; Pentraxin-3 Pentraxins Population studies Renal Dialysis - adverse effects Risk Factors Serum Amyloid P-Component - analysis |
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Title | Changes in the inflammatory and oxidative stress markers during a single hemodialysis session in patients with chronic kidney disease |
URI | https://www.tandfonline.com/doi/abs/10.1080/0886022X.2018.1487857 https://www.ncbi.nlm.nih.gov/pubmed/30277113 https://www.proquest.com/docview/3109041383 https://search.proquest.com/docview/2115754008 https://pubmed.ncbi.nlm.nih.gov/PMC6171457 https://doaj.org/article/d8c3a3806ba94bffbccf05b48e489a98 |
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