A randomized study comparing plasma concentration of ropivacaine after local infiltration analgesia and femoral block in primary total knee arthroplasty

• Published in: Scandinavian journal of pain Vol. 3; no. 1; pp. 46 - 51
• Main Authors: Affas, Fatin, Stiller, Carl-Olav, Nygårds, Eva-Britt, Stephanson, Niclas, Wretenberg, Per, Olofsson, Christina
• Format: Journal Article
• Language: English
• Published: Germany Elsevier B.V 01-01-2012; De Gruyter
• Subjects: Internal Medicine; Ketorolac, LC–MS; Local infiltration analgesia; Medicin och hälsovetenskap; Pain Medicine; Plasma concentration; Ropivacaine; Total knee arthroplasty; Local infiltration analgesia; Ketorolac, LC–MS; Total knee arthroplasty; Ropivacaine; Plasma concentration
• ISSN: 1877-8860; 1877-8879; 1877-8879
• DOI: 10.1016/j.sjpain.2011.09.001

Highlights ► High dose ropivacaine is used in local infiltration analgesia (LIA) in knee arthroplasty. ► Some patients reach potentially toxic ropivacaine plasma concentrations after LIA. ► Maximal ropivacaine plasma levels were detected 4–6 h after release of tourniquet of LIA. ► Toxicity monitoring with ECG in risk patients should cover this period of maximal plasma levels. ► Ketorolac is still present in plasma 24 h after local injection of 30 mg as part of the LIA.